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Treatment Name: |
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Reduced Dose Craniospinal Radiation (1800 cGy) and Chemotherapy in children with newly-diagnosed standard-risk posterior fossa primitive neuro-ectodermal tumor (PNET/medulloblastoma ) |
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Phase: |
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Phase 3 |
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Treatment ID#: |
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804 CHP 693 |
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Age Group: |
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Pediatric Only |
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Min Karnofsky Score: |
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Not Specified |
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Conditions: |
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Prior Surgery is Allowed Prior Radiation is Not Allowed Prior Chemotherapy is Not Allowed Age 3 - 21 years at diagnosis
Histology Proven Posterior Fossa PNET
No metastatic disease
Residual tumor volume less than 1.5 cubic centimeters
Must begin radiotherapy before 30 days from surgery
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Last Updated: |
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11/26/2005 |
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Tumor Types: |
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Medulloblastoma PNET Tumor |
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Comments: |
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Radiation Therapy: 5580 cGy tumor bed, conformal techniques; 1800 cGy craniospinal
Concurrent chemotherapy during radiation with vincristine.
Maintenance chemotherapy delivered after RT in an AABAABAAB pattern:
CCNU, Vincristine, Cisplatinum (Regimen A)
Cyclophosphamide, VP-16 (Regimen B) |
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Treatment Type: |
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Chemotherapy Radiation |
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Contact: |
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Anna J. Janss MD, Phd Winship Cancer Institute Emory University
Egleston, GA 30322 USA Phone: 404-257-3480 Fax: E-mail: Website: |
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