Details For Selected Brain Tumor Treatment

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		Treatment Name:		Phase I Trial of Aflibercept (VEGF Trap)with Radiation Therapy and Concomitant and Adjuvant Temozolomide in Patients With Malignant Gliomas

		Phase:		Phase 1/2

		Treatment ID#:		1815 NABTC 07-01

		Age Group:		Adults Only

		Min Karnofsky Score:		60: Requires occasional assistance but is able to care for most of own needs

		Conditions:		Prior Surgery is Allowed Prior Radiation is Sometimes Allowed Prior Chemotherapy is Sometimes Allowed

		Last Updated:		10/27/2008

		Tumor Types:		Anaplastic Astrocytoma Glioblastoma Multiforme Gliosarcoma Mixed Glioma Oligodendroglioma High Grade


		Comments:		VEGF Trap is a specific antagonist that binds and inactivates circulating VEGF in the blood stream and in the extravascular space. Treatment with VEGF Trap is well tolerated and resulted in evaluable response in a significant number of patients when used as a single agent, and constitutes the rationale for combination with temozolomide and radiation therapy following debulking surgery.

		Treatment Type:		Chemotherapy

		Contact:		David Reardon MD The Brain Tumor Center at Duke Rm 047 Baker House, Hospital South Trent Drive Durham, NC 27710 USA Phone: (919)684-5301 Fax: (919)684-6674 E-mail: reard003@mc.duke.edu Website: www.cancer.duke.edu/btc

Last updated refers to the date when our listing for each treatment was last updated.
ID is a combination of our internal ID and the official ID for the trial, if any.
Min Karnofsky is a general guide to how well you have to function to use this treatment

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