Details For Selected Brain Tumor Treatment

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		Treatment Name:		A Phase I Study of Vorinostat [Suberoylanilide Hydroxamic Acid (SAHA)] in Combination with Temozolomide in Patients with Malignant Gliomas

		Phase:		Phase 1

		Treatment ID#:		1679 NABTC 04-03

		Age Group:		Adults Only

		Min Karnofsky Score:		60: Requires occasional assistance but is able to care for most of own needs

		Conditions:		Prior Surgery is Allowed Prior Radiation is Allowed Prior Chemotherapy is Allowed Patients with histologically proven intracranial malignant glioma including glioblastoma multiforme, gliosarcoma, anaplastic astrocytoma, anaplastic oligodendroglioma, anaplastic mixed oligoastrocytoma, or malignant astrocytoma (not otherwise specified)

		Last Updated:		04/15/2008

		Tumor Types:		Anaplastic Astrocytoma Glioblastoma Multiforme Gliosarcoma Mixed Glioma Oligodendroglioma High Grade


		Comments:		Suberoylanilide hydroxamic acid (SAHA) is a histone deacetylase inhibitor that has demonstrated potent antitumor effects in vitro and in vivo and shows significant synergistic activity against glioblastoma when combined with either temozolomide or BCNU. Early results from phase I trials suggest that SAHA is well tolerated, and dose-limiting toxicities do not overlap with those of temozolomide.

		Treatment Type:		Chemotherapy Immunological, Biological or Targeted Therapy

		Contact:		David Reardon MD The Brain Tumor Center at Duke Rm 047 Baker House, Hospital South Trent Drive Durham, NC 27710 USA Phone: (919)684-5301 Fax: (919)684-6674 E-mail: reard003@mc.duke.edu Website: www.cancer.duke.edu/btc

Last updated refers to the date when our listing for each treatment was last updated.
ID is a combination of our internal ID and the official ID for the trial, if any.
Min Karnofsky is a general guide to how well you have to function to use this treatment

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