Details For Selected Brain Tumor Treatment
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Treatment Name: Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors
Phase: Phase 1
Treatment ID#: 1660        
Age Group: Pediatric Only
Min Karnofsky Score: Not Specified
Conditions: Prior Surgery is Allowed
Prior Radiation is Allowed
Prior Chemotherapy is Allowed
Last Updated: 11/27/2005
Tumor Types: Anaplastic Astrocytoma
Glioblastoma Multiforme
Gliosarcoma
Mixed Glioma
Oligodendroglioma High Grade
Pediatric Brain Tumors
Comments: RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, etoposide phosphate, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Mannitol may help chemotherapy work better by making it easier for these drugs to get to the tumor. Chemoprotective drugs, such as acetylcysteine and sodium thiosulfate, may protect normal cells from the side effects of chemotherapy. Giving acetylcysteine together with mannitol, combination chemotherapy, and sodium thiosulfate may be an effective treatment for malignant brain tumors
Treatment Type: Chemotherapy
Contact: Dr.Edward Neuwelt M.D.
Professor
Oregon Health Sciences University
3181 SW Sam Jackson Park Rd
L603
Portland, OR 97239 USA
Phone: (503)494-5626
Fax: (503)494-5627
E-mail: neuwelte@ohsu.edu
Website: www.ohsu.edu/bbb
  • Last updated refers to the date when our listing for each treatment was last updated.
  • ID is a combination of our internal ID and the official ID for the trial, if any.
  • Min Karnofsky is a general guide to how well you have to function to use this treatment


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