Details For Selected Brain Tumor Treatment

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		Treatment Name:		NCCTG Phase 2 Trial of CCI-779 (Temsirolimus) in Recurrent Glioblastoma Multiforme

		Phase:		Phase 2

		Treatment ID#:		1623 NCCTG N997B

		Age Group:		Adults Only

		Min Karnofsky Score:		70: Cares for self, unable to perform normal activity or to do active work

		Conditions:		Prior Surgery is Sometimes Allowed Prior Radiation is Sometimes Allowed Prior Chemotherapy is Sometimes Allowed

		Last Updated:		11/06/2005

		Tumor Types:		Glioblastoma Multiforme


		Comments:		Temsirolimus is a rapamycin ester which inhibits mTOR, and has clinical activity in glioblastoma multiforme, breast cancer and mantle cell lymphoma.[1][2][3] Temsirolimus is a dihydroester of rapamycin that is given intravenously and is undergoing phase II testing in a variety of cancers. Researchers from the Mayo Clinic treated 65 patients with recurrent glioblastoma multiforme. Non-hematologic toxicities included hypercholesterolemia, hyperglyceridemia and hyperclycemia. Neuroimaging revealed improvement in 36% of patients with responding patients having a longer survival than non-responding patients. They also observed that high levels of phosphorylated p70s6 kinase in baseline tumor samples appeared to predict response.

		Treatment Type:		Chemotherapy Less-Toxics

		Contact:		Edward Flotte MD Coastal Neurological Institute 3280 Dauphin Street Mobile , AL 36606 Phone: 800-628-5956 Fax: E-mail: eflotte@neurosurgery.umsmed.edu Website: www.cnipa.com

Last updated refers to the date when our listing for each treatment was last updated.
ID is a combination of our internal ID and the official ID for the trial, if any.
Min Karnofsky is a general guide to how well you have to function to use this treatment

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