Details For Selected Brain Tumor Treatment

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		Treatment Name:		Radiation Therapy and Stereotactic Radiosurgery With or Without Temozolomide or Erlotinib in Treating Patients With Brain Metastases Secondary to Non-Small Cell Lung Cancer

		Phase:		Phase 3

		Treatment ID#:		1604 NCT00096265

		Age Group:		Adults Only

		Min Karnofsky Score:		70: Cares for self, unable to perform normal activity or to do active work

		Conditions:		Prior Surgery is Allowed Prior Radiation is Sometimes Allowed Prior Chemotherapy is Allowed Histologically confirmed non-small cell lung cancer One to 3 intraparenchymal brain metastases by contrast-enhanced MRI, meeting the following criteria: Well circumscribed tumor(s) Maximum diameter = 4.0 cm If multiple lesions are present and one lesion is at the maximum diameter, the other lesions must be = 3.0 cm in maximum diameter No metastases within 10 mm of the optic apparatus such that a portion of the optic nerve or chiasm would be included in the high-dose stereotactic radiosurgery boost field No metastases in the brainstem, midbrain, pons, or medulla No prior complete resection of all known brain metastases Subtotal resection allowed provided residual disease is = 4.0 cm in maximum diameter No clinical or radiographic evidence of progression (other than study lesion[s]) within the past month Patients with brain metastases at initial presentation do not require 1 month of scans documenting stable disease Stable extracranial metastases allowed Extent of extracranial metastases documented by contrast-enhancing CT scans of the chest, abdomen, and pelvis AND bone scan No liver metastases No leptomeningeal metastases by MRI or cerebrospinal fluid evaluation

		Last Updated:		05/01/2007

		Tumor Types:		Metastatic Brain Tumor


		Comments:

		Treatment Type:		Chemotherapy Radiation

		Contact:		David G. Brachman MD Foundation for Cancer Research and Education Phoenix, AZ 85013 USA Phone: 602-274-4484 Fax: E-mail: Website:

Last updated refers to the date when our listing for each treatment was last updated.
ID is a combination of our internal ID and the official ID for the trial, if any.
Min Karnofsky is a general guide to how well you have to function to use this treatment

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