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Treatment Name: |
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A Phase II Study of a Temozolomide-Based Chemoradiotherapy Regimen for High-Risk Low-Grade Gliomas |
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Phase: |
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Phase 2 |
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Treatment ID#: |
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1580 NCT00114140 |
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Age Group: |
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Adults Only |
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Min Karnofsky Score: |
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60: Requires occasional assistance but is able to care for most of own needs |
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Conditions: |
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Prior Surgery is Allowed Prior Radiation is Not Allowed Prior Chemotherapy is Not Allowed Must have = 3 of the following risk factors:
Age 40 and over
Largest preoperative tumor diameter = 6 cm
Tumor crosses the midline
Astrocytoma-dominant tumor subtype
Preoperative Neurological Function Status > 1
No other low-grade glioma histologies, including any of the following:
Pilocytic astrocytoma
Subependymal giant cell astrocytoma of tuberous sclerosis
Subependymoma
Pleomorphic xanthoastrocytoma
Presence of a neuronal element, such as ganglioglioma
Dysneuroembryoplastic epithelial tumor
No high-grade glioma, including any of the following:
Anaplastic astrocytoma
Glioblastoma multiforme
Anaplastic oligodendroglioma
Anaplastic oligoastrocytoma
No tumors in any nonsupratentorial location, including any of the following:
Optic chiasm
Optic nerve(s)
Pons
Medulla
Cerebellum
Spinal cord
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Last Updated: |
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05/01/2007 |
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Tumor Types: |
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Anaplastic Astrocytoma Low Grade Glioma Oligodendroglioma Low Grade |
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Comments: |
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Treatment Type: |
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Chemotherapy Radiation |
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Contact: |
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John Wendall Goodwin MD CCOP - Cancer Research for the Ozarks
Springfield, MO 64131 USA Phone: 417-269-4520 Fax: E-mail: jwg684@sprg.mercy.net Website: |
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