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Treatment Name: |
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A Phase II Study of a Temozolomide-Based Chemoradiotherapy Regimen for High-Risk Low-Grade Gliomas |
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Phase: |
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Phase 2 |
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Treatment ID#: |
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1580 NCT00114140 |
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Age Group: |
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Adults Only |
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Min Karnofsky Score: |
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60: Requires occasional assistance but is able to care for most of own needs |
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Conditions: |
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Prior Surgery is Allowed Prior Radiation is Not Allowed Prior Chemotherapy is Not Allowed Must have = 3 of the following risk factors:
Age 40 and over
Largest preoperative tumor diameter = 6 cm
Tumor crosses the midline
Astrocytoma-dominant tumor subtype
Preoperative Neurological Function Status > 1
No other low-grade glioma histologies, including any of the following:
Pilocytic astrocytoma
Subependymal giant cell astrocytoma of tuberous sclerosis
Subependymoma
Pleomorphic xanthoastrocytoma
Presence of a neuronal element, such as ganglioglioma
Dysneuroembryoplastic epithelial tumor
No high-grade glioma, including any of the following:
Anaplastic astrocytoma
Glioblastoma multiforme
Anaplastic oligodendroglioma
Anaplastic oligoastrocytoma
No tumors in any nonsupratentorial location, including any of the following:
Optic chiasm
Optic nerve(s)
Pons
Medulla
Cerebellum
Spinal cord
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Last Updated: |
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05/01/2007 |
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Tumor Types: |
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Anaplastic Astrocytoma Low Grade Glioma Oligodendroglioma Low Grade |
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Comments: |
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Treatment Type: |
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Chemotherapy Radiation |
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Contact: |
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Jonathan P.S. Knisely MD, FRCPC Yale University School Of Medicine Contact: Colleen Malone
New Haven, CT 06520 USA Phone: 203-785-2960 Fax: E-mail: colleen.malone@yale.edu Website: |
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- Last updated refers to the date when our listing for each treatment was last updated.
- ID is a combination of our internal ID and the official ID for the trial, if any.
- Min Karnofsky is a general guide to how well you have to function to use this treatment
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