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Treatment Name: |
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Observation or Radiation Therapy and/or Chemotherapy and Second Surgery in Treating Children Who Have Undergone Surgery for Ependymoma |
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Phase: |
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Phase 2 |
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Treatment ID#: |
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1508 ACNS0121 |
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Age Group: |
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Pediatric Only |
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Min Karnofsky Score: |
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10: Fatal processes progressing rapidly |
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Conditions: |
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Prior Surgery is Allowed
Prior Radiation is Not Allowed
Prior Chemotherapy is Not Allowed
Patients must be greater than twelve months and less than twenty one years of age.
Histologically confirmed intracranial ependymoma.
No evidence of spread of disease beyond the primary site.
No prior therapy beyond surgery and corticosteroids.
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Last Updated: |
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11/27/2005 |
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Tumor Types: |
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Ependyoma |
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Comments: |
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Ependymoma is a relatively rare type of central nervous system (CNS) tumor. Standard treatment for ependymoma is surgical removal followed by post operative radiation therapy directed at the primary site. Young children, less than three years of age, typically have not received radiation therapy, but instead have received multi-agent chemotherapy in an effort to delay radiation therapy. Patients with ependymoma who have incomplete resections and those who delay radiation therapy with chemotherapy have poor overall survival.
With the help of the Children’s Oncology Group (COG), investigators want to answer important questions with the hope of improving the outcomes (improved survival with reduced side effects) for these patients by increasing the rate of complete resection and by using conformal radiation therapy for children older than 12 months of age. Researchers will investigate the use of chemotherapy in children with incomplete resections prior to second surgery, conformal radiation therapy, and no therapy after surgery for completely resected supratentorial, differentiated ependymoma
For more information: www.stjude.org/brain-tumors |
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Treatment Type: |
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Chemotherapy
Radiation |
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Contact: |
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Janice Faye Olson MD
Legacy Emanuel Hospital and Health Center & Children`s Hospital
Portland, OR 97227 USA
Phone: 503-413-2200
Fax:
E-mail:
Website: |
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- Last updated refers to the date when our listing for each treatment was last updated.
- ID is a combination of our internal ID and the official ID for the trial, if any.
- Min Karnofsky is a general guide to how well you have to function to use this treatment
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