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Trials and Noteworthy Treatments

  Treatment Next 25 Location Last Updated
Details Study of Fractionated Stereotactic Radiosurgery to Treat Large Brain Metastases Stanford, CA 09/01/2009
Details Phase I/II Trial for Patients with Recurrent Resectable Glioblastoma Multiforme Using Surgery with Implantable BCNU Polmer Followed by Post-operative Irinotecan and Bevacizumab Cincinnati, OH 08/27/2009
Details Radiation Therapy and Stereotactic Radiosurgery With or Without Temozolomide or Erlotinib in Treating Patients With Brain Metastases Secondary to Non-Small Cell Lung Cancer Oceanside, NY 05/20/2009
Details Phase II Study of CDX-110 in Patients With Glioblastoma Multiforme (GBM) (ACT III) Los Angeles, CA
Los Angeles, CA
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New Haven, CT
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Cleveland, OH
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Charlottesville, VA
Seattle, WA 		01/31/2009
Details Quality of Life in Patients with Brain Tumors, Skull Base Tumors & Pituitary Adenomas Undergoing Surgical Resection Santa Monica, CA 11/29/2008
Details Monteris AutoLITT™ FIM Safety Trial for Recurrent/Progressive Brain Tumors Cleveland, OH
Cleveland, OH 		11/19/2008
Details Phase I Trial of Aflibercept (VEGF Trap)with Radiation Therapy and Concomitant and Adjuvant Temozolomide in Patients With Malignant Gliomas Los Angeles, CA
San Francisco, CA
Boston, MA
Durham, NC
New York, NY
Pittsburgh, PA
Houston, TX
San Antonio, TX
Madison, WI 		10/27/2008
Details Erlotinib and Temozolomide With Radiation Therapy in Treating Patients With Glioblastoma Multiforme or Other Brain Tumors Charlottesville, VA 09/30/2008
Details Phase I/II Trial of Imatinib Mesylate; (Gleevec; ST1571) in Treatment of Recurrent Oligodendroglioma and Mixed Oligoastrocytoma Charlottesville, VA 09/30/2008
Details Chemotherapy, Radiation Therapy, and Vaccine Therapy With or Without Daclizumab in Treating Patients With Glioblastoma Multiforme That Has Been Removed by Surgery Durham, NC 03/02/2008
Details A Phase IIa Safety and Light Dose-Escalation Study in Patients With Primary or Recurrent/High-Grade Glioma (Defined for the Purposes of the Protocol as Anaplastic Astrocytoma [AA] or Glioblastoma Multiforme [GBM]) Using the Litx™ System to Confirm the Zone of Tumor Destruction During the Intraoperative Treatment of Glioma , Serbia 08/26/2007
Details Phase I/II Study of Fractionated CyberKnife Stereotactic Radiosurgery for High Grade Gliomas in Elderly Patients With Poor Performance Status Boston, MA 08/26/2007
Details Phase II Trial of Tumor Lysate-Pulsed Dendritic Cell Immunotherapy for Patients with Atypical or Malignant, Primary or Metastatic Brain Tumors of the Central Nervous System Los Angeles, CA 08/18/2007
Details A Phase II Trial to Evaluate the Effect of Low Dose Temozolomide (TMZ) for 2 Weeks (Pre-Surgery) on Brain Tumor O-6-Methylguanine-DNA Methyltransferase (MGMT) Activity in Patients With Gliomas. Montreal, Canada 08/18/2007
Details Functional image guided removal of brain tumors Manhasset, NY 08/18/2007
Details Phase 1 Trial Gamma Knife For Primary Brain Tumors - Gliomas. Birmingham, AL 08/18/2007
Details Phase I Study Of Pioglitazone And Isotretinoin In Patients With Recurrent Or Progressive Malignant Gliomas Los Angeles, CA 08/18/2007
Details Stereotactic Radiosurgery for Metastatic Brain Tumors Hackensack, NJ 08/18/2007
Details Open-label, Dose Confirmation and Dosimetry Study of Interstitial 131-I chTNT-1/B mAb (Cotara®) for the Treatment of Recurrent Glioblastoma Multiforme (GBM) Tustin, CA 07/31/2007
Details Phase II Study of Brachytherapy Using the Intracavity GliaSite® Radiation Therapy System (RTS) With or Without Stereotactic Radiosurgery in Patients With Newly Diagnosed Supratentorial Brain Metastases Chapel Hill, NC
Cleveland, OH 		05/01/2007
Details A Phase I/II Study Utilizing the Zeiss INTRABEAM System for the Treatment of a Resected Solitary Brain Metastasis Cleveland, OH 05/01/2007
Details Radiation Therapy and Stereotactic Radiosurgery With or Without Temozolomide or Erlotinib in Treating Patients With Brain Metastases Secondary to Non-Small Cell Lung Cancer Phoenix, AZ
Newark, DE
Orlando, FL
Columbus, GA
Dubuque, IA
Boise, ID
Harvey, IL
Hammond, IN
Kalamazoo, MI
Saint Louis Park, MN
Las Vegas, NV
Manhasset, NY
Akron, OH
Cleveland, OH
Philadelphia, PA
Salt Lake City, UT
Richmond, VA
Milwaukee, WI 		05/01/2007
Details Boswellia Serrata Combined With a Low-Fat, Vegan Diet or a Standard Diet Alone in Treating Patients Who Have Undergone Surgery and Radiation Therapy for Newly Diagnosed Glioblastoma Multiforme Cleveland, OH 04/28/2007
Details TREATMENT OF NEWLY DIAGNOSED, HIGH-GRADE, MALIGNANT GLIOMA WITH POLIFEPROSAN 20 CONTAINING CARMUSTINE IMPLANT (GLIADEL® WAFER) USING MR SPECTROSCOPY DATA AS A PRIMARY INDICATOR OF THERAPEUTIC RESPONSE New York, NY 10/12/2006
Details Erlotinib and Temozolomide With Radiation Therapy in Treating Patients With Glioblastoma Multiforme or Other Brain Tumors Birmingham, AL
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Lincoln, NE
Allentown, PA 		06/26/2006

News Stories

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  (0.9281)   How do you know when it is time for another surgery for a recurrent glioblastoma multiforme? Is there a limit to the number of surgeries?

  (0.8912)   Meningioma removed by surgery Dec.1999. Meningioma recurred and removed by surgery Jan.2002.Treated with a course of radiotherepy May/June.What are the chances of further recurrance.

  (0.8912)   My husband who has just recently had surgery for a reccurence, path report now says mixed glioma(oligo and astro), is recommended by doctors to do stereotactic surgery. It has been described as being done with a ~~halo~~ bolted to his head. Questions: How often can he have this done? How successful can it be with an infiltrating tumor? Will the radiation cause permanent damage to brain tissue? What are the side effects? How will he feel afterwards? Thank you.

  (0.8792)   I recently had surgery to remove a grade 2 astrocytoma in my brain. My neurosurgeon says the operation was successful and he thinks he removed 80-90%. After surgery, an EEG test discovered there was still seizure activity in the brain. Is that normal? It is three weeks after surgery and I smoke 30 cigarettes per day. Is this going to effect my tumor?

  (0.8792)   My wife is 56 years old and recently had surgery to remove a brain tumor (on the right side of her brain) that ended up being an astrocytoma; 95% only could be removed as the surgeon stated that removing the remaining 5% might result in paralysis due to close proximity to the brain stem. Following surgery, she had continued headaches. She then had surgery due to hydrocephalus developing, and required a permanent shunt with it draining to the abdominal cavity, One day later, the surgeon informed me that he had sent a sample of fluid collected during surgery away for testing and that he may need to perform a frontal or temporal lobotomy. What would make this necessary and how does one proceed with decisions?

  (0.8792)   My 44-year-old brother was diagnosed with Oligoastrocytoma in the Corpus Callossum / Ventricles region last year after suffering over 6 years of non-responsive major depression, personality change and finally unrelenting headaches. He was raced into surgery where they removed 95% of the tumour and sent biopsies to the lab. The remaining 5% is the size of a man's thumb according to the surgeon (so the tumour must have been huge) The surgeon said the risk of major impairment was too great to risk removing the final area of tumor. Post surgery, he was treated with anti-seizure meds for 12 weeks. His MRI following surgery, and again 12 weeks later, showed no growth and he was told he did not require radiation or chemtherapy. He missed his next appointment/MRI at Christmas time and has just had his next follow up - six months since the last. His scans show the tumor has grown again and his neurosurgeon is now saying it is time to remove what was left after the initial surgery. He was told after his initial surgery that the pathology results indicated the tumour was benign (grade 2 or 3). My question is, why has he not been trated already with chemo or radiotherapy given that it seems to be standard treatment for his type of tumor. Also, does the fact that the surgeon now thinks removing the part he left behind initially is necessary mean the tumor has become a more aggressive form of cancer? My brother lives in another state and is being treated in the largest hospital in that state, but as he is in Australia, he does not have access to many, if any, second opinions. Are you able to shed any light on what might be happening?

  (0.8658)   My sister was diagnosed with a GBM on her right frontal lobe. She had a craniotomy to remove the tumor but the neurosurgeon said that he was only able to remove about 80% because, when he got in, he noticed that it had crossed the midline. It has been seven weeks since her surgery and she just now started radiation and Temodar. She was developing headaches again and double vision so they took another MRI and it shows that the tumor has grown back. What do they mean by the tumor has crossed the midline? Does this mean that it is inoperable? Can't surgery be performed on each side of the lobe to remove as much as possible? The surgeon never ordered an MRI after the surgery so we really do not know how much was really taken. Is this normal?

  (0.8658)   how serious is a brain tumor? What are the chances of survival after surgery of brain tumor? What is the recovery time after a brain tumor surgery? How long does a brain tumor surgery take?

  (0.8658)   I would like more info re: genetic testing of tumors, and about tx choices. My previously healthy 50 yr old husband had a craniotomy 9/5/01 to remove a frontoparietal mass, 5cm, after sx of 3 months~ duration of increasing weakness of his left hand and arm, and finally left leg weakness (originally misdiagnosed as Chronic Inflammatory Demyelinating Polyneuropathy.) The surgery was excellent and no tumor showing on post surgery MRI. He has had an amazing recovery from surgery and has just finished 7 weeks radiation without any side effects. His only deficit is residual arm/hand hemiparesis. He is running 2 miles a day and climbing mountains. Scheduled to start PCV chemo in 11/29/01. Repeat MRI scheduled for 11/27. His final pathology report (at Dartmouth-Hitchcock Medical Ctr.) called it a ~~highly malgnant neoplasm with histologic features of glioblastoma, with and unequivocable oligodendroglial component.~~ We heard opinions from varying sources that it was important to ~~get the genetic testing done~~ when there was a mixed tumor with oligo component. In seeking a second opinion at Mass General, the pathologist there said it was a ~~grade IV glioblastoma with recognizable oligodendrial component.~~ We were told there that the chromosome 1P loss testing was only being used in grade III oligo tumors, but would not be applicable to my husband~s grade IV tumor. In both centers, the opinion was that PCV was standard tx which they would recommend using as they wish to tx him aggressively given the overall excellent state of his health, relative youth, and positive attitude. But I am still uncertain about the role of the genetic testing when there is even some oligo component. Would it still be worthwhile getting the testing done, and what would that tell us? If it showed that he did not have the genetic type to respond to PCV, would it not be wiser to choose a different type of chemo such as Temodar...something less toxic and that would give him a better quality of life? Please comment! We have a wonde

  (0.8512)   Why is gamma knife sometimes done and surgery done at other times. What makes the difference and is one better than the other.

  (0.8511)   My mom was diagnosed 4 years ago with GBM. She was 54 at the time. She had surgery with total gross resection followed by adjuvant radiation and Temod(daily for 28 days and 5 days off - 2 cycles). Since then she had been taking Celebrex/Vioxx daily and has been doing very well. A few weeks ago, she was diagnosed with recurrent GBM in the same area, although not as deep and not as big. She had surgery. Post-op MRI shows residual tumor. Surgeon wants to re-operate to remove the rest of it and then do stereotactic radiosurgery. Other doctors want to do Gliadel or IL-13. Since she had such a good response with Temodar shouldn't we do that again? What would you recommend for next steps?

  (0.8510)   My sister (39) had surgery to remove an astrocytoma, grade 2, 6 weeks ago. This is the 3rd surgery in just under 10 years. The hospital has just given her the results and it is now grade 4 (having grown back rapidly and giving her symptoms for the first time, headaches, dizziness, etc.) Radiation and Temedor are scheduled to begin at the beginning of November 2007, 6 weeks of both, then 6 months of Temador. This means 11 weeks have lapsed since surgery. We are concerned that the tumor will grow back during this period. Should she be starting treatment immediately?

  (0.8510)   In June 2003, my 16-year-old daughter was diagnosed with a colloid cyst in the third ventricle (approximately 6 mm). After several months and different medications, surgery was performed to remove the cyst. However, the doctor was only able to remove 1 mm due to the closeness to her short term memory area. Her surgery and recovery went well; however, she still suffers from severe headaches at least once a week (up to 3 times a week) that usually leave her pretty much incapacitated for 24 to 36 hours. She just had another post surgery MRI done and the report shows the colloid cyst the same, but the radiologist's report also states that there is a pineal cyst and something about hemorragic products. Should I be worried about this pineal cyst? She will be 17 years old in February, so would this still be considered pediatrics or adult? The doctor had talked once about a spinal fluid exam, should this be considered? As I stated, she still has frequent, severe headaches and the surgery has caused some short-term memory problems. It has been a scary year, but she seems to be doing well. I do not want to be an over-anxious, worried mother, but I want the best for her health.

  (0.8510)   My friend was diagonized in early May, 2004, with Glioblastoma Multiforme. He had surgery, radiation, and chemotherapy. After radiation, they did an MRI and it showed a new growth so he started the chemotherapy and, after four chemo treatments, they did another MRI and it had gotten bigger. They now want to do another surgery and try a different chemo. Are there any significant things we should worry about with the second surgery and, since it is still growing after radiation and chemotherapy, what are his chances of survival and how long?

  (0.8510)   My father, 67, in China, was diagnosed with grade III glioma by end of Feb and removed by surgery on March 20 this year. After surgery the MRI still shows a 2x3mm ~~shadow~~, before surgery that~s 4x5cm. Has had radiation in Aril, and 4 cycles of chemotherapy May thru Sept. Last week MRI shows the ~~shadow~~ grow to 5x7mm, and we just heard the TEMODAR. Should we consider Gamma Knife procedure now, or take TEMODAR, or both ? If only one we can pick, which is better to control the growing ~~shadow~~ ?

  (0.8510)   My dad had a meningioma removed 27 years ago. e lost most of the feeling on the left side of his body following the surgery and they were unable to replace the bone flap due to swelling of the brain. He also suffered a few seizures through the years. He had a cyst removed 2 years ago in the same area of his head and at that time they added an artificial bone. He has complained of feeling as if he is in a daze all of the time since the second surgery and says if he tries to stand still he feels like he is swaying back and forth. He feels fine when he is moving and he walks 5 miles a day with no problem. His problem results if he is standing still. Is this an equilibrium problem as a result of the surgery? Is there a medication or procedure that can help him? We do not know where to turn. His doctors have been of little help.

  (0.8510)   Is it recommended for a woman, age 36, with Anaplastic Astrocytoma, who completed radiation and is now doing chemotherapy with Temodar, to have surgery to remove the brain tumor? Is there evidence that surgery prolongs life expectancy?

  (0.8510)   Minimizing risk of artery/vein damage during neurosurgery: I have been diagnosed with an Astrocytoma Grade 2 (size 2.5 cm by 3.5 cm) recently; the doctor has indicated that there is a risk of damaging the arteries/veins during resection surgery. Is there any way to reduce/minimize risk or the amount of damage caused when a vein is cut? (for example: extreme lowering of the body temp?).

  (0.8510)   Thank you for your reply to my question re treatment Oligo/Asto.II - Is it your opinion that surgery if it is possible is best in the first instance. I note from letter from others that as soon as surgery is done the tumour usually changes to a more agressive type - or am I wrong? My tumour size is big 5.5x 5.5cm My neurosurgen said that surgery is to releave symtons only and as I had none I should not risk dangerous surgery. He had been going to operate l998 when the tumour was at the Superior Temporal Gyrus. unforturnately this op had to be cancelled as my husband took ill and later died. So surgery was put off by my surgeon saying there was no change and doing yearly scans, until Sept. 2001. The MRI showed small focali contrast enhancement in the depth paticularly of the posturo temporal and parietal foci. He was sure it had turned anaplastic I also started having a metalic taste in my mouth from time to time. He ordered a biopsy (my first) December 2001 but this showed no anaplasia and still a low grade Tumour. The took 17 biopsies but did not have the technoclogy to test for chemo agents. I have had three opinions on treatment. Chemo- PCV from Liverpool. London - It could be helped by chemo but it would take a long time, therefore radiotherapy. Edinburgh standard treatment radiotherapy. I have an appointment in Glasgow next Tuesday. I feel that radiotherapy is effective in fast growing tumours but is there any evidence that it is effective in low grades. Steriotactic radiotherapy may be no use as mine is too large.Thank you once again for your reply I am impressed.

  (0.8510)   Hi, I had a tumor reseructed on feb 11 2002. this tumor was a atipical meningioma. Though this was 100% removed the doctors say that it is better to have a radio surgery so that all the cells in this location will be killied. I am ready to go for this, But i am afraid of the side effects of this. I have heard that on the long run the part where the the brain was treated might get damaged. I had the tumor right above my speech part of the brain. I am afraid that my speech part might have this effect if i take up the radio surgery. After the surgery i was not able to speak due to swelling. But now i am able to speak abt 80% and i know that i will be fine in a few days. because i can see the changes in my speech. Will you please give your comments regarding the radio surgery.

  (0.8351)   I HAD A CPA RESECTION ON JULY 13,2007 FOR AN EPIDERMOID TUMOR THE SIZE OF A LARGE PEPPERMINT PATTY. I HAD MY 6-MONTH MRI ON JAN 29, 2008. THEY SAID I STILL HAVE A SMALL PART OF THE TUMOR ATTACHED TO THE BRAIN STEM. I AM HAVING SEIZURES. IS THIS CAUSED BY THE PART THAT IS LEFT? I WAS HAVING SEIZURES BEFORE THE SURGERY. THAT IS HOW THEY FOUND THE TUMOR. I DIDN'T HAVE ANY SEIZURES AFTER THE SURGERY UNTIL THIS MONTH. NOW I~VE HAD TWO. THEY ARE ABSENCE SEIZURES WITH AN AURA. I ALSO HAVE A FORTY TO SIXTY PERCENT BLOCKAGE IN MY CAROTID ARTERY. DO YOU HAVE ANY IDEAS ABOUT WHAT IS GOING ON? THE DOCTOR THAT DID MY SURGERY IS A GREAT SURGEON, BUT NOT MUCH ON GIVING INFORMATION.

  (0.8351)   My father had a reoccurence of a GBM twelve months after the first surgery, in the same spot as the first. He had surgery and is now doing chemo with Avastin. He has had zero reactions to the chemo. Does that tend to mean he may have a longer survival time? He has already beaten the odds! Anyway, of the patients of yours that have survived GBM for up to 10 years versus the ones who did not, is there a main reason or factor for that? My dad's tumor was in the speech/short term memory area of the brain.

  (0.8351)   My father-in-law was diagnosed with glioblastoma multiforme 2 years ago. Since then he has undergone 4 de-bulking surgeries, 33 radiation treatments, IV chemotherapy, oral(pill) chemotherapy, implanted gliadel wafers (twice) along with a myriad of anti-inflammatory drugs. None of this seems to be working. He is slowly declining physically. Mentally he is in good shape but physically he can no longer walk due to his left side being paralyzed. The doctors claim this is due to the position of the tumor and the compounded effect of the de-bulking surgeries.The doctors claim that they cannot do any more surgeries and that the next step is hospice. Is there anything else out there that we are overlooking that may be of benefit. This individual is very strong willed and is willing to try anything for a chance at survival. Thank you for any and all assisstance in this matter.

  (0.8351)   I am a 39 year old man .I recently have had an Oligo grade 2 resected in June (20th). Complete resection and the tumor presented by way of a Grand Mal Seizure 1 month prior surgery. Since surgery...we~ve decided to watch and wait. I go back for MRI in November. I ~ve had one focal seizure and when my Depakote level was checked it was low...we added a pill up to 4 and checked again still low and now we are adding another pill. 2 in the morning and now 3 at night. My question is this: Is it possible that I~ll ever get to be get off the meds for seizures? ( Just wondering) Also...I am experiencing that when I rise from a seated position like for instance once riding in a car and then get out...I feel pressure in my head . In the mornings I have headaches. From what I~ve read this could be due to tumor growth. OR am I still healing from surgery. Today is the 8-8-03 and surgery was 6/20/03? Could the Depakote be causing this as a side effect? Would Keppra be an alternative to elliviate this?

  (0.8351)   Can all brain tumor be removed by surgery? Is it possible for as 14 year old girl to have brain tumor that can not be remove by brain surgery?




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