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Trials and Noteworthy Treatments

  Treatment Next 25 Location Last Updated
Details A Phase I Trial and Pharmacokinetic Study of Trabectedin (Yondelis®, ET-743) in Children and Adolescents With Relapsed or Refractory Solid Tumors Bethesda, MD 04/22/2009
Details Multiple Ascending Dose (MAD) Study of the IGF-1R Antagonist R1507 Administered as an Intravenous Infusion in Pediatric Patients With Advanced Solid Tumors. Bethesda, MD 04/22/2009
Details Quality of Life in Patients with Brain Tumors, Skull Base Tumors & Pituitary Adenomas Undergoing Surgical Resection Santa Monica, CA 11/29/2008
Details Phase II Study of Intrathecal I-3F8 in Patients With GD2-Expressing Central Nervous System and Leptomeningeal Neoplasms New York, NY 08/20/2007
Details Phase II Trial of Tumor Lysate-Pulsed Dendritic Cell Immunotherapy for Patients with Atypical or Malignant, Primary or Metastatic Brain Tumors of the Central Nervous System Los Angeles, CA 08/18/2007
Details Brain Mapping for Brain Tumors Boston, MA 08/18/2007
Details Phase 3 study: Radiation Therapy and Combination Chemotherapy Followed by Autologous Stem Cell Transplant in Treating Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor Durham, NC
Memphis, TN
Houston, TX
05/02/2006
Details "Head Start" chemotherapy protocol for children less than 10 years old with newly diagnosed high grade primary brain tumors with intent to eliminate irradiation and abbreviate total duration of treatment to 6 months with resultant improved cure rate and quality of survival. Oakland, CA 05/01/2006
Details Headstart II A Phase II study of two alternative intensive induction chemotherapy followed by consolidation with myeloablative chemotherapy and autologous stem cell rescue with or without subsequent radiation therapy for children less than 10 yrs of age newly diagnosed with malignant brain tumors Oakland, CA 05/01/2006
Details Temozolomide Plus Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Malignant Glioma or Recurrent CNS or Other Solid Tumors Durham, NC 12/04/2005
Details Pharmacological intervention for learning impaired children surviving treatment for cancer. Durham, NC 12/03/2005
Details Gamma Knife Radiosurgery for Brain Tumors La Jolla, CA 12/03/2005
Details Phase I trial of Temozolomide (Temodar) and O6-Benzylguanine (o6-bg)in pediatric patients with recurrent brain tumors. Durham, NC 12/03/2005
Details Pilot study of systemic and intrathecal chemotherapy followed by conformal radiation for infants with embryonal intracranial central nervous system tumors. Durham, NC 12/03/2005
Details A Phase I dose escalation trial of Temodar that will attempt to determine the maximum tolerated dose of Temodar (Temozolomide) when given by prolonged oral exposure to children with recurrent or progressive brain tumors. New York, NY 12/03/2005
Details Gamma Knife Radiosurgery Edison, NJ 12/03/2005
Details Gamma knife stereotactic radiosurgery for benign and malignant brain tumors and brain metastases. Rockville Centre, NY 12/03/2005
Details Quality of Life Studies (There are 19 seperate studies listed here) Durham, NC 12/03/2005
Details Treatment of newly diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor (PNET), or Atypical Teratoid Rhabdoid Tumor (ATRT) Memphis, TN 12/03/2005
Details A Phase I/II Study of Reirradiation for Recurrent Pediatric Brain and Spinal Cord Tumors and Primary Glioblastoma Multiforme Using the Photon Radiosurgery System Chicago, IL 11/27/2005
Details A Pilot Study of 1H-Nuclear Magnetic Resonance Spectroscopic Imaging in Pediatric Patients with Primary and Metastatic Brain Tumors Bethesda, MD 11/27/2005
Details A Phase I, Molecular Biology, and Phase II Study of Lapatinib (GW572016) in Pediatric Patients with Recurrent or Refractory Medulloblastoma, Malignant Glioma or Ependymoma Washington, DC
Chicago, IL
Boston, MA
Durham, NC
Philadelphia, PA
Pittsburgh, PA
Memphis, TN
Memphis, TN
Houston, TX
Seattle, WA
11/27/2005
Details Computer Assisted Stereotactic Navigation For Resection Of Brain Tumors In Children And Adults Hackensack, NJ 11/27/2005
Details Double sequential high dose Thiotepa with autologous stem cell rescue for patients age <60 years with recurrent malignant brain cancer. Los Angeles, CA 11/27/2005
Details Functional brain Mapping Of Motor And Speech Areas For Resection Of Tumors Near Functional Areas Of The Brain Hackensack, NJ 11/27/2005


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Frequently Asked Questions



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  (0.7742)   My 4 year old daughter, Erin, was diagnosed on 8-11-02 with a Diffuse Pontine Glioma. She immediately was enrolled in a Clinical Trial by her Doctor, at Children~s Memorial Hospital. This trial uses Carboplatin Monthly and Thalidomide Daily as well as Radiation Therapy. She has undergone about 14 sessions of Radiation directly to her Pons Tumor. She has responded very well. We know this because another MRI was performed on her Brain on 8-27-02. Based on her complaints of occasional back pain, her Dr. ordered a Spinal MRI. This MRI showed new tumor growth (very early) in the cervical spine area. He performed a spinal tap yesterday and feels the tumor cells are PNET. It has been decided to now include the entire brain, brain stem and spine in the radiation treatment. She will begin this new radiation regimen beginning Tuesday, September 10th. Her chemotherapy regimen will also be changed to 3 chemotherapy drugs that are proven to be somewhat effective with PNET Tumors. I understand how rare this occurance is. Erin is otherwise very healthy. We were told that her diagnosis has occurred early in her disease. My question to you is do you have any knowledge of any other children with PNET Pontine Gliomas that also had secondary cervical tumors, that were diagnosed very early and received radiation and chemotherapy. If so, how were they treated and what was the outcome. I appreciate your time. Thank you, Michele F.





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