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  (0.7967)   I would like more info re: genetic testing of tumors, and about tx choices. My previously healthy 50 yr old husband had a craniotomy 9/5/01 to remove a frontoparietal mass, 5cm, after sx of 3 months~ duration of increasing weakness of his left hand and arm, and finally left leg weakness (originally misdiagnosed as Chronic Inflammatory Demyelinating Polyneuropathy.) The surgery was excellent and no tumor showing on post surgery MRI. He has had an amazing recovery from surgery and has just finished 7 weeks radiation without any side effects. His only deficit is residual arm/hand hemiparesis. He is running 2 miles a day and climbing mountains. Scheduled to start PCV chemo in 11/29/01. Repeat MRI scheduled for 11/27. His final pathology report (at Dartmouth-Hitchcock Medical Ctr.) called it a ~~highly malgnant neoplasm with histologic features of glioblastoma, with and unequivocable oligodendroglial component.~~ We heard opinions from varying sources that it was important to ~~get the genetic testing done~~ when there was a mixed tumor with oligo component. In seeking a second opinion at Mass General, the pathologist there said it was a ~~grade IV glioblastoma with recognizable oligodendrial component.~~ We were told there that the chromosome 1P loss testing was only being used in grade III oligo tumors, but would not be applicable to my husband~s grade IV tumor. In both centers, the opinion was that PCV was standard tx which they would recommend using as they wish to tx him aggressively given the overall excellent state of his health, relative youth, and positive attitude. But I am still uncertain about the role of the genetic testing when there is even some oligo component. Would it still be worthwhile getting the testing done, and what would that tell us? If it showed that he did not have the genetic type to respond to PCV, would it not be wiser to choose a different type of chemo such as Temodar...something less toxic and that would give him a better quality of life? Please comment! We have a wonde

  (0.7742)   what are the differences in the different phases of clinical trials





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