Trials and Noteworthy Treatments

			Treatment		Location		Last Updated
	Details		A Pilot Study of Temozolomide and 06Benzylguanine for Treatment of Newly Diagnosed High Grade Glioma, Using Autologous Peripheral Blood Stem Cells Genetically Modified for Chemoprotection		Cincinnati , OH		05/01/2007
	Details		Genetic Therapy of meningiomas and gliomas in the Malay population in the NorthnEast coast of Malaysia		Kelantan, Malaysia, MALAYSIA		11/27/2005
	Details		Gene Therapy Of Malignant Gliomas: A Pilot Study of Vaccination With Autologous Glioma-Lysate And Dendritic Cells Admixed With IL-4 Transduced Fibroblasts To Elicit An Immune Response.		Pittsburgh, PA		11/21/2005
	Details		An Open-label, Dose Confirmation and Dosimetry Study of Interstitial 131I-chTNT-1/B MAB (COTARA) for the Treatment of Glioblastoma Multiforme (GBM) at 1st of 2nd Relapse		Baltimore, MD		11/06/2005

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•   (0.9961)   A virus for the brain [Scroll down to the section on brain]
  
  
•   (0.9957)   $14.3 Million Federal Grant Fuels Cardiovascular Gene Therapy Program At University Of Pittsburgh (US Newswire)
  ...clinical investigators have applied this technology to problems ranging from heart disease to cancer.......Clinical trials have included novel therapies for an inherited metabolic disorder and for cancers of the breast and brain....
  - Jan 02 11:00 AM ET
  
  
•   (0.9653)   Researchers find that combined gene therapy eliminates glioblastoma multiforme in lab studies
  
  
•   (0.9653)   Today`s Findings From the ASGT Annual Meeting: New Research on Neurological Disorders and Cancer Gene Therapy (PR Newswire)
  ...Researchers injected altered forms of Huntington`s disease into rat brains to determine which mutations are associated with specific pathol......both at the site of injection and throughout the other parts of the brain, researchers concluded the brains of these mice appeared largely......cancer gene therapy alert immune system to presence and locations of tumors SEATTLE (Friday, June 1, 2001) -......Tumor cells take up the DNA/lipid complex and express pieces of the HL...
  - Jun 01 1:03 PM ET
  
  
•   (0.9527)   Aventis Pharma to Create New Gencell Entity; Aventis Pharma and Introgen to Restructure Their Collaboration in Gene Therapy (Canada NewsWire)
  ...INGN 201 uses a proprietary adenoviral technology to target the p53 gene to kill cancer cells and suppress tumor growth through multiple molecular mechanisms.......Introgen is also conducting a Phase II clinical trial for INGN 201 in lung cancer and Phase I trials for INGN 201 in additional cancer indications including prostate, ovarian, bladder, brain and breast cancer.......INGN 241 (Adenoviral-mda7) for the treatment of solid tumors, is in Phase I clinical development....
  - Apr 02 4:16 PM ET
  
  
•   (0.9527)   Aventis Pharma to Create New Gencell Entity; Aventis Pharma and Introgen to Restructure Their Collaboration in Gene Therapy (PR Newswire)
  ...INGN 201 uses a proprietary adenoviral technology to target the p53 gene to kill cancer cells and suppress tumor growth through multiple molecular mechanisms.......Introgen is also conducting a Phase II clinical trial for INGN 201 in lung cancer and Phase I trials for INGN 201 in additional cancer indications including prostate, ovarian, bladder, brain and breast cancer.......INGN 241 (Adenoviral-mda7) for the treatment of solid tumors, is in Phase I clinical development....
  - Apr 02 5:06 PM ET
  
  
•   (0.9416)   Poliovirus may be used for gene therapy (Reuters)
  Scientists report that they are one step closer to taming the harmful poliovirus, and using it to treat spinal cord injuries and conditions like multiple sclerosis through gene therapy.
  - Aug 30 5:38 PM ET
  
  
•   (0.9352)   Gene Therapy `Trains` Immune System to Destroy Brain Cancer Cells and Reverse Behavioral Deficits
  
  
•   (0.9352)   Re-engineered neural stem cells use a bystander effect to target glioma
  
  
•   (0.9352)   Evolution of a Gene Therapy Clinical Trial
  
  
•   (0.9282)   GenStar Therapeutics Announces Issuance of Patent for Sensitizing Tumors to Radiation Using Gene Therapy (Business Wire)
  GenStar Therapeutics, a biotechnology company developing products for the treatment of hemophilia A and prostate cancer, announced today the issuance of U.S. Patent No. 6,051,218 entitled, "Tumor Radiosensitization Using Gene Therapy." This University of California patent covers a method of inhibiting the growth of a cancerous tumor by delivering the cytokine gene interleukin-3 to sensitize tumors to standard radiation therapy.
  - Apr 25 9:02 AM ET
  
  
•   (0.9203)   Intravenous, non-viral RNAi gene therapy of brain cancer
  
  
•   (0.9115)   Brain tumor treatment uses radiation and gene therapy
  
  
•   (0.9115)   Introgen and Texas Heart Institute Collaborate to Study Gene Therapy Approaches to Cardiovascular Disease (PR Newswire)
  ...Introgen is also conducting a Phase II clinical trial for INGN 201 in lung cancer and Phase I trials for INGN 201 in additional cancer indications including prostate, ovarian, bladder, brain, and breast cancer.......INGN 241 (Adenoviral-mda7), for the treatment of solid tumors, is in Phase I clinical development....
  - Mar 14 7:30 AM ET
  
  
•   (0.9115)   Introgen and Texas Heart Institute Collaborate to Study Gene Therapy Approaches to Cardiovascular Disease (PR Newswire)
  ...Introgen is also conducting a Phase II clinical trial for INGN 201 in lung cancer and Phase I trials for INGN 201 in additional cancer indications including prostate, ovarian, bladder, brain, and breast cancer.......INGN 241 (Adenoviral-mda7), for the treatment of solid tumors, is in Phase I clinical development....
  - Mar 14 7:30 AM ET
  
  
•   (0.9115)   Clinical trials with retrovirus mediated gene therapy--what have we learned?
  
  
•   (0.9017)   Columbia research lifts major hurdle to gene therapy for cancer
  
  
•   (0.9017)   AVAX Technologies Receives Contract From French Army to Evaluate Gene Therapy Technology (PR Newswire)
  ...The company has completed initial Phase I testing of the TK suicide gene technology in 20 patients with glioblastoma, a malignant brain tumor, and 11 patients with late stage melanoma....
  - Feb 05 8:00 AM ET
  
  
•   (0.9017)   Intravenous RNA Interference Gene Therapy Targeting the Human Epidermal Growth Factor Receptor Prolongs Survival in Intracranial Brain Cancer
  
  
•   (0.9017)   Gene Therapy Slows Brain Tumor Growth in Mice (Reuters)
  An experimental cancer treatment delivered by way of gene therapy has been found to slow the growth of brain tumors in mice. The findings, researchers say, may provide clues for developing new treatments for humans.
  - Feb 22 5:26 PM ET
  
  
•   (0.9017)   Gene Therapy Improves Effects of Radiation (Reuters)
  ... cancer cells, and after a few days, they injected the tumors with a harmless virus that carried the gene for EGFR-......Tumor cells in the mice treated with the mutant gene were...... localized advanced cancers of the head and neck and the brain.``...
  - Jun 21 5:33 PM ET
  
  
•   (0.9017)   Introgen`s Adenoviral Vector Demonstrates Safety in Phase II Study; Biosafety Data Presented at American Society of Gene Therapy Meeting (PR Newswire)
  ...is a replication-impaired adenoviral vector carrying the human p53 tumor suppressor gene.......additional cancer indications including prostate, ovarian, bladder, brain, and breast cancer.......candidate, INGN 241 (Adenoviral-mda7), for the treatment of solid tumors, is in Phase I clinical development....
  - Jun 01 7:30 PM ET
  
  
•   (0.8912)   AVAX Technologies` TK Suicide Gene Data Published in Peer Reviewed Journal Gene Therapy (PR Newswire)
  AVAX Technologies, Inc. today announced that new data relating to its thymidine kinase suicide gene program has been published in an article entitled, "Transient control of a virus-induced immunopathology by genetic immunosuppression" in the peer-reviewed journal, Gene Therapy (2000 Sep;7(18):1536-42).
  - Oct 18 8:06 AM ET
  
  
•   (0.8792)   Ark`s £27.1M Funding Should Fuel Pipeline`s Confirmation [Brain tumor gene therapy]
  
  
•   (0.8792)   Protein Delivered Via Genetically Engineered Virus Slowed Glioblasoma Multiforme Growth
  
  

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