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Search Term: cpt-11
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Trials and Noteworthy Treatments

  Treatment Location Last Updated
Details A Phase II Trial of Bevacizumab (avastin) and Irinotecan (CPT-11) for Patients With Recurrent High-Grade Gliomas Immediately Following Tumor Progression After Treatment With Bevacizumab Alone: A Companion Trial to NCI Study 06-C-0064 (Bevacizumab Alone for Recurrent Gliomas) Bethesda, MD 04/21/2009
Details A Phase I Trial of Nanoliposomal CPT-11 (NL CPT-11) in Patients With Recurrent High-Grade Gliomas San Francisco, CA 04/06/2009
Details Bevacizumab (Avastin) and Irinotecan (CPT-11) in Treating Young Patients With Recurrent, Progressive, or Refractory Glioma, Medulloblastoma, Ependymoma, or Low Grade Glioma San Francisco, CA
Washington, DC
Chicago, IL
Boston, MA
Bethesda, MD
Durham, NC
Philadelphia, PA
Pittsburgh, PA
Memphis, TN
Seattle, WA
11/08/2008
Details A Phase II Trial of Thalidomide in combination with Temozolomide or CPT-11 in patients with recurrent anaplastic gliomas or glioblastoma multiforme Houston, TX 10/27/2008
Details A Phase II Trial With Bevacizumab (Avastin) and Irinotecan (CPT-11) for Patients With Primary Brain Tumors and Progression After Standard Therapy Copenhagen, Denmark 08/18/2007
Details Combination Therapy With Thalidomide and CPT-11 in Patients With Recurrent Anaplastic Gliomas or Glioblastoma Multiforme Houston , TX 04/15/2007
Details Phase I/II Study of High Dose Irinotecan (Camptosar, CPT-11) in Patients With Recurrent Unresectable Malignant Glioma on Steroids/Anti-Epileptics Louisville, KY 05/29/2006
Details A Phase I Trial Using Combination Irinotecan (CPT-11) and Thalidomide for Recurrent CNS Tumors Albuquerque, NM 05/02/2006
Details Phase I trial of Temodar plus O6-Benzylguanine plus Irinotecan (CPT-11) in the treatment of patients with recurrent/progressive Cerebral anaplastic gliomas. Durham, NC 12/03/2005
Details ZD1839 and Oral Irinotecan in Treating Young Patients with Refractory Solid Tumors Memphis, TN 12/03/2005
Details Evaluation of CPT-11 (Irinotecan) in chemonaive patients with inoperable brain metastases from non-small cell lung cancer Bennington, VT 11/21/2005
Details Phase II treatment with Irinotecan (CPT-11) plus Celebrex® of adults with primary malignant glioma. Durham, NC 11/20/2005
Details Phase I treatment with Irinotecan (CPT-11) plus Temozolomide (Temodar) of children with primary recurrent malignant brain tumors. Durham, NC 11/13/2005
Details Pilot study of Irinotecan (CPT-11) given concurrently with 76 Gy of conformal multiple fraction per day External Beam Radiotherapy followed by Maintenance Therapy with BCNU plus Irinotecan (CPT-11) for newly diagnosed diffuse pontine glioma. Durham, NC 11/13/2005


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  (0.8658)   My mom (59 years old) was diagnosed with a 14 mm left temporal lobe GBM on 10/16/07. She had a gross total resection with minimal defecits. She was part of a trial where she completed 6 wks of radiation with daily TEMODAR and bi-weekly infusions of AVASTIN. She had platelet issues and had to stop briefly. She completed one cycle of full strength TEMODAR (5 days) and two cycles of AVASTIN and CPT-11. However, the AVASTIN & CPT-11 have caused mom to be in the hospital with colitis and diverticulitis. Due to these issues, we have stopped AVASTIN & CPT-11, but continue on full strength TEMODAR (5 days on, 23 days off). The great news is that mom is 5 months out and her MRI shows absolutely no tumor. However, we had to stop the aggressive treatment and will now rely on TEMODAR only. What can we anticipate (realistically) for survival moving forward?

  (0.8169)   My 40-year-old husband has had numerous surgeries, initial Temodar and radiation treatments, allergic to Temodar, and had three treatments of BCNU. Now he is having CPT 11 every two weeks. He is on a low dose because he tested positive for becoming toxic. After his second dose, he had diarrhea. Are there any more choices for treatments if he can not continue with CPT 11?

  (0.7742)   Could you help my husband with a question about his current chemo choices. He was treated for glioblastoma multiforme with surgery (2/05), radiation and Temodar (spring 05, allergic reaction), then BCNU (Fall 05) and another surgery (02/06). He was given three choices following his pathology report that identified a very slight presence of cancerous cells in what they recently removed. They had to do a stain in order to find anything. He can do nothing and watch the MRIs, try CCNU (they say it may affect his lungs much like the BCNU had), or a combination of hydroxyurea and gleevec. Do you have any information or referrals for information on the last choice? And do you agree CCNU affects the lungs like BCNU?





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