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Trials and Noteworthy Treatments

  Treatment Next 25 Location Last Updated
Details A Pilot Study to Evaluate the Effects of Vaccinations with HLA-A2-Restricted Glioma Antigen-Peptides in Combination with Poly-ICLC for Children with Newly Diagnosed Malignant or Intrinsic Brain Stem Gliomas (BSG) or Incompletely Resected Non-Brainstem High-Grade Gliomas (HGG) or Recurrent Unresectable Low-Grade Gliomas (LGG) or Recurrent High Grade Gliomas Pittsburgh, PA 09/23/2009
Details Phase 1 Study of Azixa (MPC-6827) and Carboplatin in Recurrent/Relapsed Glioblastoma Multiforme Los Angeles, CA
Atlanta, GA
New York, NY
Houston, TX
Salt Lake City, UT 		08/11/2009
Details A Phase II Safety and Tolerability Study of Avastin When Added to Single-Agent Chemotherapy to Treat Patient With Breast Cancer Metastatic to Brain West Palm Beach, FL
Charlotte, NC
Durham, NC 		06/16/2009
Details Phase III Randomized, Parallel Group, Multi-Centre Study in Recurrent Glioblastoma Subjects to Compare the Efficacy of AZD2171 [RECENTIN] Monotherapy and the Combination of AZD2171 with Lomustine to the Efficacy of Lomustine Alone Cincinnati, OH 04/06/2009
Details Phase III, randomised, parallel Group, multi-centre study in recurrent glioblastoma patients to compare the efficacy of cediranib monotherapy and the combination of cediranib with lomustine to the efficacy of lomustine alone Houston, TX 04/03/2009
Details A Pilot Study to Evaluate the Effects of Vaccinations with HLA-A2-Restricted Glioma Antigen-Peptides in Combination with Poly-ICLC for Adults with High-Risk WHO Grade II Astrocytomas and Oligo-Astrocytomas Pittsburgh, PA 01/06/2009
Details Monteris AutoLITT™ FIM Safety Trial for Recurrent/Progressive Brain Tumors Cleveland, OH
Cleveland, OH 		11/19/2008
Details BIBW 2992 with or without daily temozolomide in the treatment of patients with recurrent malignant glioma Charlottesville, VA 10/20/2008
Details Phase I/II Trial of Imatinib Mesylate; (Gleevec; ST1571) in Treatment of Recurrent Oligodendroglioma and Mixed Oligoastrocytoma Charlottesville, VA 09/30/2008
Details A Randomized Phase II Trial of Bevacizumab With Irinotecan or Bevacizumab With Temozolomide in Recurrent Glioblastoma Houston, TX 04/15/2008
Details Chemotherapy, Radiation Therapy, and Vaccine Therapy With or Without Daclizumab in Treating Patients With Glioblastoma Multiforme That Has Been Removed by Surgery Durham, NC 03/02/2008
Details A phase I/II Evaluation of Vaccination with Type-1 Dendritic Cells Pulsed With Multiple Peptides In the Treatment of HLA-A2 Positive Patients With Recurrent Malignant Gliomas Pittsburgh, PA 03/02/2008
Details Phase I/II trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine For Patients With Recurrent High Grade Glioma San Francisco, CA 10/03/2007
Details Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma or Supratentorial Primitive Neuroectodermal Tumor Hamilton, Canada
Perth, Western Australia, 6001, Australia
Orange, CA
Sacramento, CA
Washington, DC
St. Petersburg, FL
West Palm Beach, FL
Atlanta, GA
Indianapolis, IN
Kansas City, MO
Charlotte, NC
Paterson, NJ
Summit, NJ
New York, NY
Columbus, OH
Oklahoma City, OK
Pittsburgh, PA
San Antonio, TX
Roanoke, VA
Charleston, WV 		08/18/2007
Details Phase I Study Of Pioglitazone And Isotretinoin In Patients With Recurrent Or Progressive Malignant Gliomas Los Angeles, CA 08/18/2007
Details Open-label, Dose Confirmation and Dosimetry Study of Interstitial 131-I chTNT-1/B mAb (Cotara®) for the Treatment of Recurrent Glioblastoma Multiforme (GBM) Tustin, CA 07/31/2007
Details A Pilot Study of Temozolomide and 06Benzylguanine for Treatment of Newly Diagnosed High Grade Glioma, Using Autologous Peripheral Blood Stem Cells Genetically Modified for Chemoprotection Cincinnati , OH 05/01/2007
Details Methotrexate, Cyclophosphamide, and Etoposide Phosphate Given With Osmotic Blood-Brain Barrier Disruption Plus Dexamethasone and Cytarabine in Treating Patients With Primary CNS Lymphoma Cleveland, OH
Portland, OR 		05/01/2007
Details Phase II Study of Erlotinib in Patients With Recurrent or Progressive Glioblastoma Multiforme Cleveland, OH 04/15/2007
Details TREATMENT OF NEWLY DIAGNOSED, HIGH-GRADE, MALIGNANT GLIOMA WITH POLIFEPROSAN 20 CONTAINING CARMUSTINE IMPLANT (GLIADEL® WAFER) USING MR SPECTROSCOPY DATA AS A PRIMARY INDICATOR OF THERAPEUTIC RESPONSE New York, NY 10/12/2006
Details Vorinostat in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme Scottsdale/Phoenix, AZ
Jacksonville, FL
Des Moines, IA
Sioux City, IA
Rochester, MN
Saint Louis Park, MN
Bismarck, ND
Fargo, ND 		06/26/2006
Details Phase I/II Trial of Imatinib Mesylate; (Gleevec; ST1571) in Treatment of Recurrent Oligodendroglioma and Mixed Oligoastrocytoma Jacksonville, FL
Jacksonville, FL
Des Moines, IA
Moline, IL
Peoria, IL
Urbana, IL
Wichita, KS
Lambertville, MI
Rochester, MN
Saint Louis Park, MN
Billings, MT
Bismarck, ND
Lincoln, NE
Danville, PA
Spartanburg, SC
Sioux Falls, SD 		06/26/2006
Details Phase 3 study: Radiation Therapy and Combination Chemotherapy Followed by Autologous Stem Cell Transplant in Treating Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor Durham, NC
Memphis, TN
Houston, TX 		05/02/2006
Details A Pilot Study of Dronabinol for the treatment of nausea,vomiting and appetite loss in Adult Patients With Primary Gliomas Durham, NC 05/01/2006
Details "Head Start" chemotherapy protocol for children less than 10 years old with newly diagnosed high grade primary brain tumors with intent to eliminate irradiation and abbreviate total duration of treatment to 6 months with resultant improved cure rate and quality of survival. Oakland, CA 05/01/2006

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  (0.8912)   >Hi, > >My partner was diagnosed with an anaplastic astrocytoma III two months ago. It >is located above the thalamus and was biopsied only. He is completing six >weeks of radiotherapy with 8 treatments to go. We have seen two >neuro-oncologists who have differening opinions on chemotherapy. One of the >doctors has advised treatment with BCNU commencing one month after >radiotherapy is completed. This would be done every 8 weeks for a year. >The other doctor has advised not using any chemotherapy until there is a >recurrence. > >Can you please advise if there are any trial results on timing of >chemotherapy and which chemotherapy regimen is most beneficial in the >treatment of AA grade 3. Also any other trial results that look promising. > >We are in Melbourne, Australia so have limited access to trials but are >willing to fly to the States if need be. > >Thanks >Michelle Wheller

  (0.8912)   >Hi, > >My partner was diagnosed with an anaplastic astrocytoma III two months ago. It >is located above the thalamus and was biopsied only. He is completing six >weeks of radiotherapy with 8 treatments to go. We have seen two >neuro-oncologists who have differening opinions on chemotherapy. One of the >doctors has advised treatment with BCNU commencing one month after >radiotherapy is completed. This would be done every 8 weeks for a year. >The other doctor has advised not using any chemotherapy until there is a >recurrence. > >Can you please advise if there are any trial results on timing of >chemotherapy and which chemotherapy regimen is most beneficial in the >treatment of AA grade 3. Also any other trial results that look promising. > >We are in Melbourne, Australia so have limited access to trials but are >willing to fly to the States if need be. > >Thanks >Michelle Wheller

  (0.8658)   My grandpa just had his radiation therapy to shrink his tumor. Doctors are suggesting that he should start his chemotherapy, as his tumor is on a more advanced stage. He actually has lung cancer, but it has spread in to his brain. Doctors are saying that he should start on chemotherapy. He is 76 yrs old, and we are afraid that chemo might have worse effects on him. He is feeling really good after taking radiation. Our concern is will chemo help him or ruin his lifestyle.

  (0.8658)   My friend was diagonized in early May, 2004, with Glioblastoma Multiforme. He had surgery, radiation, and chemotherapy. After radiation, they did an MRI and it showed a new growth so he started the chemotherapy and, after four chemo treatments, they did another MRI and it had gotten bigger. They now want to do another surgery and try a different chemo. Are there any significant things we should worry about with the second surgery and, since it is still growing after radiation and chemotherapy, what are his chances of survival and how long?

  (0.8351)   While on chemotherapy treatment, blood test results showed abnormal liver function. ALT 135 / AST 51 / GGT 151. Is this something serious?

  (0.8351)   My father-in-law was diagnosed with glioblastoma multiforme 2 years ago. Since then he has undergone 4 de-bulking surgeries, 33 radiation treatments, IV chemotherapy, oral(pill) chemotherapy, implanted gliadel wafers (twice) along with a myriad of anti-inflammatory drugs. None of this seems to be working. He is slowly declining physically. Mentally he is in good shape but physically he can no longer walk due to his left side being paralyzed. The doctors claim this is due to the position of the tumor and the compounded effect of the de-bulking surgeries.The doctors claim that they cannot do any more surgeries and that the next step is hospice. Is there anything else out there that we are overlooking that may be of benefit. This individual is very strong willed and is willing to try anything for a chance at survival. Thank you for any and all assisstance in this matter.

  (0.8351)   My son finished his second protocol of chemotherapy (procarbazine, thioguanine, CCNU and vincristine) in Feb. 2005. His first chemotherapy protocol was Carboplatin and Vincristine for 12 months ending in early 2003. Both protocols showed initial shrinkage and then stability; however, his dosages were reduced in protocol II due sometimes to low counts. Sometimes his oral dosage was too much for his system and he was sick, not allowing the full dosages to be consumed. We do not know if he was able to get the full effect of the second protocol. The Grade II Fibrilary Thalamic Astrocytoma that is currently stable in the right peduncle measures approximately 2.3 cm by 2.3 cm by 2.0 cm. What do you suggest other than waiting for it to grow and then consider another chemotherapy regimen at that time. He has not yet had any radiation of any type, but is functioning well.

  (0.8351)   Is it recommended for a woman, age 36, with Anaplastic Astrocytoma, who completed radiation and is now doing chemotherapy with Temodar, to have surgery to remove the brain tumor? Is there evidence that surgery prolongs life expectancy?

  (0.8351)   My 4 year old daughter, Erin, was diagnosed on 8-11-02 with a Diffuse Pontine Glioma. She immediately was enrolled in a Clinical Trial by her Doctor, at Children~s Memorial Hospital. This trial uses Carboplatin Monthly and Thalidomide Daily as well as Radiation Therapy. She has undergone about 14 sessions of Radiation directly to her Pons Tumor. She has responded very well. We know this because another MRI was performed on her Brain on 8-27-02. Based on her complaints of occasional back pain, her Dr. ordered a Spinal MRI. This MRI showed new tumor growth (very early) in the cervical spine area. He performed a spinal tap yesterday and feels the tumor cells are PNET. It has been decided to now include the entire brain, brain stem and spine in the radiation treatment. She will begin this new radiation regimen beginning Tuesday, September 10th. Her chemotherapy regimen will also be changed to 3 chemotherapy drugs that are proven to be somewhat effective with PNET Tumors. I understand how rare this occurance is. Erin is otherwise very healthy. We were told that her diagnosis has occurred early in her disease. My question to you is do you have any knowledge of any other children with PNET Pontine Gliomas that also had secondary cervical tumors, that were diagnosed very early and received radiation and chemotherapy. If so, how were they treated and what was the outcome. I appreciate your time. Thank you, Michele F.

  (0.8351)   What is the significance of a low platelet count, and what can we do to make it go back up.. It came down because of a chemotherapy.

  (0.8351)   My mother has just had surgery to remove a large plum-sized cancerous glioma tumor. Apart from traditional radiotherapy and chemotherapy, what other (innovative and new) treatments are available. Is it possible for her to survive this brain tumor?

  (0.8347)   My 11-year-old son was diagnosed with metastatic medulloblastoma in April, 2003. He underwent surgery and Head Start II protocol (high dose chemotherapy with stem cell rescue) and then underwent 6 weeks of radiation to the posterior fosse and spine. In November, 2005, another tumor was discovered on the frontal lobe. It was removed. Six weeks of radiation was done to the frontal lobe. Chemotherapy was started: oral Temodar, IV vincristine and oral CCNU. In April, 2007, while still on chemotherapy, another tumor was found on the ventricle. Surgery was done, an an Ommaya reservoir was placed, and he has been undergoing Topetecan since April. Our doctors are considering another stem cell rescue. Ethan has stem cells from the first collection in 2003. He would only undergo the 3 days of high dose chemo to wipe out his immune system. Our only other option is to continue with Topetecan which he tolerates very well. Please advise on 2nd stem cell rescue and any studies you have read about or if this is done or not.

  (0.8169)   My mother had surgery on 2 occasions for a brain tumor and was diagnosed with GBM. After surgery, she underwent seven weeks radiotherapy with not much problem. At present, she has undergone one chemotherapy course out of six courses. Her age at present is 60. What are the further courses of action? Also, please let me know the seriousness of the problem, and the length of time my mother will have, and also the medicines avalable in India for controlling this tumor against reoccurence?

  (0.8169)   5/4/02 I was diagnosed with an oligoastrocytoma grade 2. I had a complete resection. Currently we are getting various opinions on post-treatment. I am 18 years old and left with some paralysis on my right side. I am working hard to regain movement but it is going to take some time. Should I go with the chemotherapy or the wait and see option?

  (0.8164)   HOW DOES THE RADIATION THERAPY WORKS,ON BRAINSTEM GLIOMA TUMOR, CLASIFFIED LOW GRADE?

  (0.8164)   I hear about the risk of developing leukemia if you take temodar too long. How likely is it? Is it a higher chance than with other chemotherapies? What is the longest that you would keep someone on temodar, assuming they have been stable, but there is still tumor on the mris? thanks

  (0.7967)   I have recently completed my 12th cycle of Temodar on a schedule of 5 days on, 23 days off. I am now contemplating continuing this chemotherapy, because I feel it has kept me from having a reoccurrence. I hardly have side effects when taking it and my blood counts have always been good. Does anyone have experience taking Temodar beyond a 12-month cycle? If so, please share your experience.

  (0.7967)   My brother has GMB lV. Tumor was removed 7-3-07. He went thru 42 days of radiation and chemotherapy (Temodar). He has MRIs every 2 months. Dr. says all looks the same each time. He now takes thioguine for a few days, then 5 days of temodar (420mg), then accutane. The Dr. says there is necrosis in the original tumor site. I am worried that the scans won't really show if the tumor is still gone or not because of the necrosis. Should I be? My brother also has headaches unless he is on steriods. He also takes Topamax I believe. The Dr. had him start taking that along with the steriods when his brain began to swell when he started his temodar a few months back. His head hurt so bad that he couldn't stand it. He also had terrible vomiting and had to be air-lifted to the hospital. He weaned off the steriods about 2 weeks ago and almost immediately started having headaches again. He restarted the steriods and the headaches stopped. He has gained weight and can loose his temper and become VERY angry at the drop of a pin. He tolerates his monthly treatment pretty well except the Temador makes him very nauseous even with meds for nausea. Is all of this to be expected? I don't know. We have talked to his Dr. but we feel like we never get a direct answer.

  (0.7967)   My mother is suffering from stage IV GBM. Surgery could not be done since it was a deep-seated tumor. She has received radiotherapy and 6 cycles of chemotherapy with Temozolomide, but there isn~t any decrease/increase in the size of the tumour (4cm). What should we do now? Clinically, she is fine.

  (0.7967)   Is radiation therapy the best first-line course of treatment for an inoperable low-grade astrocytoma in the left frontal lobe?

  (0.7967)   Why is Temodar prescribed on radiation days only? What is the usual first course of treatment for a grade 4 glioblastoma? How many days of radiation and chemotherapy (Temodar)?

  (0.7967)   My sister, Liza Kusmartini, 32 years old, 157 cm height and 59.4 kg, had brain surgery to remove a tumor on the front left side of her head two weeks ago (January 6, 2007) (Neurosurgery - Army hospital - Jakarta, Indonesia). After surgery, the doctor said that only a small part of tumor was removed. Another tumor located in the Broca's area has not been removed since it would reduce her quality of life. Histopathology tests have been done at 2 different laboratories to examine tumor tissues. The result was mixed glioma oligodendroglioma and astrocytoma grade 2-3. Liza is in treatment at home now. In February, the doctor is planning to arrange radiation therapy at 75mg/m2 for 30 days and oral chemotherapy (Temodal/temozolomide 120 mg), followed by adjuvant Temodal/telozomide 320 mg-6 cycles. Is this the right treatment for my sister? Because it is so costly for my family, we don't have enough money for that treatment. What are the side effects after treatment?

  (0.7967)   My father was diagnosed with a benign Meningioma four years ago. He underwent brain surgery, gamma knife, radiation, chemotherapy, and clinical trial drugs. About three months ago, we found out that it turned into malignant, aggressive Meningioma. He just had two brain surgeries in the past 3 months and he is experiencing many problems. The tumors are so big they are growing out of his head. Plus, he had two blood clots in his brain, gets seizures, has memory loss, cannot walk, and a lot of other things. Now, the doctors saw some spots in his lungs and we will get the results of that soon. I just want someone to tell me why this happens. I want to know about the neurons, the cells, the dendrites, anything you can tell me that would make me understand how all this happens. I am 19 years old, and I would like to know if this could be passed to me and if I should go see a specialist or something.

  (0.7967)   My father, age 68, was diagnosed with a mixed anaplastic oligoastrocytoma brain tumor. The tumor was surgically removed and the the doctor said they were able to remove 95% of the tumor. He has undergone radiation therapy, and 32 days of chemotherapy (Temodar, 120 mg). He is currently taking another round of chemotherapy (Temodar, 300 mg x 5 days out of 28 days for 6 months). We are trying to find out what the survival rates for this type of brain cancer are? Also, are there any alternative treatments that have had success treating this type of brain tumor.

  (0.7967)   What are the benefits of thalidomide with Temodar as the second chemotherapy treatment for grade 4 oligodendroglioma. Surgery and radiotherapy have already been given, followed by PCV.




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