Trials and Noteworthy Treatments

			Treatment Next 25		Location		Last Updated
	Details		A Pilot Study to Evaluate the Effects of Vaccinations with HLA-A2-Restricted Glioma Antigen-Peptides in Combination with Poly-ICLC for Children with Newly Diagnosed Malignant or Intrinsic Brain Stem Gliomas (BSG) or Incompletely Resected Non-Brainstem High-Grade Gliomas (HGG) or Recurrent Unresectable Low-Grade Gliomas (LGG) or Recurrent High Grade Gliomas		Pittsburgh, PA		09/23/2009
	Details		A Phase I Trial and Pharmacokinetic Study of Trabectedin (Yondelis®, ET-743) in Children and Adolescents With Relapsed or Refractory Solid Tumors		Bethesda, MD		04/22/2009
	Details		A Phase I/II Trial of ZD6474 for Patients With Recurrent High-Grade and Progressive Low-Grade Gliomas		Bethesda, MD		04/22/2009
	Details		A Phase II Study of Pegylated Interferon Alfa-2b (PEG-INTRON) in Children With Diffuse Pontine Gliomas		Bethesda, MD		04/22/2009
	Details		Multiple Ascending Dose (MAD) Study of the IGF-1R Antagonist R1507 Administered as an Intravenous Infusion in Pediatric Patients With Advanced Solid Tumors.		Bethesda, MD		04/22/2009
	Details		An Open Label Dose Escalation Safety Study of Convection-Enhanced Delivery of IL13-PE38QQR in Patients With Progressive Pediatric Diffuse Infiltrating Brainstem Glioma and Supratentorial High-Grade Glioma		Bethesda, MD		04/15/2009
	Details		Quality of Life in Patients with Brain Tumors, Skull Base Tumors & Pituitary Adenomas Undergoing Surgical Resection		Santa Monica, CA		11/29/2008
	Details		Bevacizumab (Avastin) and Irinotecan (CPT-11) in Treating Young Patients With Recurrent, Progressive, or Refractory Glioma, Medulloblastoma, Ependymoma, or Low Grade Glioma		San Francisco, CA Washington, DC Chicago, IL Boston, MA Bethesda, MD Durham, NC Philadelphia, PA Pittsburgh, PA Memphis, TN Seattle, WA		11/08/2008
	Details		Gliogene: An International Brain Tumor Study		Houston, TX		07/24/2008
	Details		A Phase l Trial of Tumor Associated Antigen Pulsed Dendritic Cell Immunotherapy for Patients With Brain Stem Glioma and Glioblastoma		Los Angeles, CA		03/02/2008
	Details		NTI 0501: An Open-Labeled, Extended-Use of Human Corticotropin-Releasing Factor (hCRF) (Xerecept) Intended for Patients Who Participate in Dexamethasone-Sparing Studies NTI 0302 or NTI 0303		Kingston, Ontario, CANADA Edmonton, Alberta, CANADA Moncton, New Brunswick, CANADA Ottawa, Ontario, CANADA Toronto, Ontario, CANADA Winnipeg, Manitoba, CANADA Phoenix, AZ La Jolla, CA Palo Alto, CA Sacramento, CA Aurora, CO Englewood, CO Jacksonville, FL Orlando, FL Chicago, IL Evanston, IL Boston, MA Detroit, MI Winston-Salem, NC Edison, NJ Buffalo, NY Columbus, OH Columbus, OH Portland, OR Memphis, TN Nashville, TN Seattle, WA Madison, WI		03/01/2008
	Details		Brain Mapping for Brain Tumors		Boston, MA		08/18/2007
	Details		Phase II Randomized Study of Intra-Arterial Carboplatin, Cyclophosphamide, and Etoposide or Etoposide Phosphate With or Without Delayed High-Dose Sodium Thiosulfate in Patients With High-Grade Glioma		Cleveland, OH Columbus, OH Portland, OR		05/01/2007
	Details		Erlotinib (Tarceva) Alone or in Combination With Radiation Therapy in Treating Young Patients With Refractory or Relapsed Malignant Brain Tumors or Newly Diagnosed Brain Stem Glioma		Dublin,		04/15/2007
	Details		Safety Study of Tarceva in Children With Refractory and Relapsed Malignant Brain Tumors and Newly Diagnosed Brain Stem Glioma		Villejuif, France		04/15/2007
	Details		Comprehensive Genetic Analysis Of Brain Tumors In Children. (A Non-Therapeutic Study)		, , Canada , Canada , Canada , Canada , Canada , Canada , Switzerland , Switzerland Auckland, New Zealand Perth, Western Australia, 6001, Australia Randwick, New South Wales, 2031, Australia Phoenix, AZ Downey, CA Loma Linda, CA Los Angeles, CA Los Angeles, CA Los Angeles, CA Madera, CA Oakland, CA Orange, CA Orange, CA Sacramento, CA San Francisco, CA Santa Barbara , CA Travis Air Force Base, CA Denver, CO Farmington, CT Washington, DC Washington, DC Wilmington, DE Atlanta, GA Macon, GA Savannah, GA Des Moines, IA Chicago, IL Chicago, IL Park Ridge, IL Indianapolis, IN Springfield, MA Baltimore, MD Ann Arbor, MI Detroit, MI Grand Rapids, MI Kalamazoo, MI Royal Oak, MI Royal Oak, MI Minneapolis, MN Rochester, MN Kansas City, MO Chapel Hill, NC Charlotte, NC Winston-Salem, NC Fargo, ND Omaha, NE Omaha, NE Brunswick, NJ Newark, NJ Paterson, NJ Summit, NJ Las Vegas, NV Albany, NY Bronx, NY Brooklyn, NY Brooklyn, NY Brooklyn, NY Brooklyn, NY New Hyde Park, NY New York, NY Stony Brook, NY Syracuse, NY Akron, OH Cincinnati, OH Cleveland, OH Columbus, OH Dayton, OH Toledo, OH Portland, OR Danville, PA Philadelphia, PA Pittsburgh, PA Sioux Falls, SD Johnson City, TN Knoxville, TN Nashville, TN Amarillo, TX Austin, TX Dallas, TX Houston, TX Lubbock, TX San Antonio, TX San Antonio, TX Temple, TX Norfolk, VA Seattle, WA Seattle, WA Spokane, WA Tacoma, WA Green Bay, WI Green Bay, WI Green Bay, WI La Crosse, WI Madison, WI Marshfield, WI Marshfield, WI Huntington, WV		10/12/2006
	Details		Phase I/II Study of Topotecan, Filgrastim (G-CSF), and Radiotherapy in Young Patients With Newly Diagnosed Malignant Intrinsic Pontine Brain Stem Glioma		, Canada , Canada Perth, Western Australia, 6001, Australia Little Rock, AR Phoenix, AZ Downey, CA Farmington, CT Gainesville, FL Jacksonville, FL Miami, FL Orlando, FL Pensacola, FL Honolulu, HI Boise, ID Chicago, IL Peoria, IL Indianapolis, IN Indianapolis, IN Kansas City, KS Louisville, KY Boston, MA Boston, MA Bangor, ME Detroit, MI Grand Rapids, MI Kalamazoo, MI Rochester, MN Kansas City, MO Saint Louis, MO Jackson, MS Charlotte, NC Lebanon, NH New Brunswick, NJ Summit, NJ Albuquerque, NM Las Vegas, NV New York, NY Syracuse, NY Valhalla, NY Cincinnati,, OH Cleveland, OH Columbus, OH Dayton, OH Oklahoma City, OK Hershey, PA Pittsburgh, PA Charleston, SC Columbia, SC Nashville, TN Amarillo, TX Corpus Christi, TX Dallas, TX Fort Worth, TX Salt Lake City, UT Spokane, WA Charleston, WV Huntington, WV		05/30/2006
	Details		Pilot Randomized Study of Modafinil for Treatment of Fatigue and Neurobehavioral Dysfunction in Patients With Primary Brain Tumors		Los Angeles, CA		05/29/2006
	Details		Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors		Washington, DC Chicago, IL Boston, MA Bethesda, MD Philadelphia, PA Pittsburgh, PA Memphis, TN Houston, TX Seattle, WA		05/27/2006
	Details		Phase 2 Study of Vinblastine in Children With Recurrent or Refractory Low Grade Glioma		Toronto, Ontario, , CANADA		05/21/2006
	Details		Headstart II A Phase II study of two alternative intensive induction chemotherapy followed by consolidation with myeloablative chemotherapy and autologous stem cell rescue with or without subsequent radiation therapy for children less than 10 yrs of age newly diagnosed with malignant brain tumors		Oakland, CA		05/01/2006
	Details		Phase II Study of O6-Benzylguanine and Temozolomide (Temodar) in Pediatric Patients With Recurrent or Progressive High-Grade Gliomas or Brain Stem Tumors		Chicago, IL Bethesda, MD Durham, NC Durham, NC Lincoln, NE Philadelphia, PA Memphis, TN Houston, TX Seattle, WA		05/01/2006
	Details		Pharmacological intervention for learning impaired children surviving treatment for cancer.		Durham, NC		12/03/2005
	Details		Gamma Knife Radiosurgery		Smithtown, NY		12/03/2005
	Details		Gamma Knife Radiosurgery for Brain Tumors		La Jolla, CA		12/03/2005

News Stories

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•   (0.8912)   Topotecan as a radiosensitizer in the treatment of children with malignant diffuse brainstem gliomas.
  
  
•   (0.8658)   Role of temozolomide after radiotherapy for newly diagnosed diffuse brainstem glioma in children.
  
  
•   (0.8510)   Gamma knife surgery for focal brainstem gliomas.
  
  
•   (0.8510)   Natural history and management of brainstem gliomas in adults : A retrospective Italian study.
  
  
•   (0.8510)   Researchers Successfully Deliver Drugs to the Primate Brainstem
  
  
•   (0.8510)   Surgical Outcome following Resection of Contrast-Enhanced Pediatric Brainstem Gliomas.
  
  
•   (0.8351)   A Phase I study of concurrent RMP-7 and carboplatin with radiation therapy for children with newly diagnosed brainstem gliomas.
  
  
•   (0.8169)   Phase 1 study of concurrent RMP-7 and carboplatin with radiotherapy for children with newly diagnosed brainstem gliomas.
  
  
•   (0.8169)   Preradiation chemotherapy in primary high-risk brainstem tumors: phase II study CCG-9941 of the Children`s Cancer Group.
  
  
•   (0.7967)   Cancer drug from Cuba undergoes rare U.S. trial (for brainstem glioma as well as GBMs)
  
  
•   (0.7967)   Establishment of experimental glioma models at the intrinsic brainstem region of the rats.
  
  
•   (0.7967)   Temozolomide in Malignant Gliomas of Childhood: A United Kingdom Children’s Cancer Study Group and French Society for Pediatric Oncology Intergroup Study <
  
  
•   (0.7742)   Brain Tumor News Blast - fundraising appeal
  
  
•   (0.7742)   Pilot trial of the rate of response, safety, and tolerability of temozolomide and oral VP-16 in patients with recurrent or treatment-induced malignant central nervous system tumors.
  
  
•   (0.7742)   Phase I Trial of Single-Dose Temozolomide and Continuous Administration of O6-Benzylguanine in Children with Brain Tumors: a Pediatric Brain Tumor Consortium Report
  
  
•   (0.7742)   New vaccine trial opens for pediatric (ages 3 to 20) high grade, low grade and brainstem glioma
  
  
•   (0.7742)   Second Annual Kortney`s Challenge - 2 Mile FUN Run/Walk - Raising money and awareness for pediatric brain tumors ONE STEP AT A TIME (NJ)
  
  
•   (0.7742)   The treatment of high grade gliomas and diffuse intrinsic pontine tumors of childhood and adolescence: a historical - and futuristic - perspective.
  
  

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