Note - they do not link anywhere yet.. that will be added soon.
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197 active trials

•  [20] Stereotactic Radiosurgery for High Grade Gliomas, for Lesions <4cm AND >4cm. Brachytherapy for Lesions >4cm
•  [24] Stereotactic Radiosurgery VS. Conventional Radiotherapy for Recurrent / Invasive Pituitary Tumors
•  [27] Stereotactic Radiosurgery for Metastatic Brain Tumors
•  [31] Multiple Courses of High Dose Chemotherapy With Peripheral Stem Cell Support in Relapsed, Refractory or Progressive Glial Tumors and in Children With Glioblastoma or Incompletely Resected Anaplastic Astrocytoma at the Time of Diagnosis.
•  [34] High precision fractionated stereotactic radiotherapy for adult intracranial neoplasms.
•  [35] High precision fractionated stereotactic radiotherapy for pediatric tumors.
•  [96] "Head Start" chemotherapy protocol for children less than 10 years old with newly diagnosed high grade primary brain tumors with intent to eliminate irradiation and abbreviate total duration of treatment to 6 months with resultant improved cure rate and quality of survival.
•  [101] Fractionated Stereotactic Radiosurgery plus Topotecan radiation sensitizer in the treatment of recurrent malignant astrocytoma or as consolidation after external beam radiotherapy.
•  [174] Phase 2 Trial of Stereotactic Radiosurgery For Recurrent Pediatric Brain Tumors
•  [175] Stereotactic Radiosurgery Following Surgical Resection of Malignant Meningiomas
•  [176] Phase 2 Trial of Multi-Agent High Dose Chemotherapy Followed By Stem Cell Rescue For High Grade Gliomas in Adults.
•  [189] Phase 2 Study of Recurrent, Residual or Progressive Skull Base Meningioma Treated with Radiosurgery.
•  [204] Longitudinal Neuropsychologic Evaluation And Strategic Educational Interventions.
•  [205] Rehabilitation For Brain Tumor Patients.
•  [223] Phase 1 Trial Gamma Knife For Primary Brain Tumors - Gliomas.
•  [239] Frameless Computer Guided Stereotactic Surgery For Brain Tumors
•  [272] Feasibility of using oral Etoposide combined with escalating doses of Tamoxifen for children with recurrent gliomas
•  [279] Functional image guided removal of brain tumors
•  [290] Gliadel Wafer Implantation For Malignant Gliomas Of The Brain
•  [302] Regulus Navigator for use with a three point pinion - frameless stereotactic surgery
•  [303] Volumetric Stereotactic Procedures
•  [325] Risk Adapted, Multimodal Therapy In Newly Diagnosed Supratentorial Malignant Glioma, Stratified To KPS.
•  [331] Adoptive IL-2 activated LAK cell intratumoral immunotherapy implant with adjuvant radiosurgery boost and naturopathic/nutritional immune enhancement. This is for newly diagnosed patients only.
•  [332] Computer assisted minimally invasive image guided surgery for improved resection of malignant brain tumors and frameless stereotactic brain biopsies For Deep Brain Tumors.
•  [350] Double sequential high dose Thiotepa with autologous stem cell rescue for patients age <60 years with recurrent malignant brain cancer.
•  [367] Accelerated Radition Therapy With ARCON For Glioblastomas
•  [380] Phase I/II Study of Multiple Light Fiber Interstitial Photodynamic Therapy for Primary and Metastatic Supratentorial Brain Tumors
•  [396] Intraoperative MRI for brain tumors
•  [404] Treatment of newly diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor (PNET), or Atypical Teratoid Rhabdoid Tumor (ATRT)
•  [443] Computer Assisted Stereotactic Navigation For Resection Of Brain Tumors In Children And Adults
•  [444] Functional brain Mapping Of Motor And Speech Areas For Resection Of Tumors Near Functional Areas Of The Brain
•  [445] Use of Epilepsy Monitoring And Electrocorticography For Seizure Control In Patients With Brain Tumors
•  [459] Use of Hight Dose Tamoxifen For Patients Who Refuse Surgery For meningiomas and Gliomas.
•  [460] Genetic Therapy of meningiomas and gliomas in the Malay population in the NorthnEast coast of Malaysia
•  [461] Endoscopic ventriculostomy for obstructive hydrocephalus in terminal patients with hydrocephalus and brain tumours.
•  [462] Aggresive emergency tumour debulking and craniectomy for patients with tumours of more than 80ml and glasgow coma scale of less than 8.
•  [483] Intraoperative navigation in neurosurgical patients
•  [549] Phase I Dose Escalation Study of Gliadel in Adults with Recurrent Malignant Gliomas
•  [561] Reliable Imaging Diagnosis of Recurrent Brain Tumor
•  [563] Bio-Anatomic Radiation Treatment Planning for Newly Diagnosed Glioblastoma multiforme
•  [564] Conventional Radiation Therapy + Thalidomide for Supratentorial Glioblastoma
•  [565] Dose Escalation Study of RT Using 3-Dimensional Treatment Planning for Newly Diagnosed GBM
•  [566] Chemotherapy,radiotherapy and immunotherapy for brain tumors.
•  [596] Phase I/II Trial of Temodar and Escalating Doses of Oral VP-16 for Patients with Recurrent Malignant Glioma
•  [616] A Phase I dose escalation trial of Temodar that will attempt to determine the maximum tolerated dose of Temodar (Temozolomide) when given by prolonged oral exposure to children with recurrent or progressive brain tumors.
•  [617] Headstart II A Phase II study of two alternative intensive induction chemotherapy followed by consolidation with myeloablative chemotherapy and autologous stem cell rescue with or without subsequent radiation therapy for children less than 10 yrs of age newly diagnosed with malignant brain tumors
•  [710] Use of interferon for the treatment of gliomas of the brain and spine.
•  [712] Chemosensitivity for Malaysian Brain tumors
•  [719] Long-term survivors of high grade gliomas.
•  [758] Phase II Treatment of Patients with Progressive Low Grade Gliomas with Temodal
•  [760] Intrathecal Methotrexate in Leptomeningeal Carcinomatis in Breast Cancer
•  [798] Brain tumor surgery using a compact intraoperative MRI
•  [809] Intra-arterial carboplatin for supratentorial brain tumors
•  [817] Phase I, Gliadel® & Escalating Doses of Intravenous O6-Benzylguanine in People with Recurrent Malignant Glioma
•  [818] MGH 99-114. A phase II study of systemic topotecan in patients with CNS metastatic carcinoma
•  [828] A Phase II Trial of Cisplatinum and Temodar followed by Cranial Irradiation and Temodar in Adults with Newly Diagnosed Glioblastoma Multiforme
•  [854] A Phase I Gliadel and Escalating Doses of Intravenous O6-Benzylguanine Trial in Patients with Recurrent Malignant Glioma
•  [858] Gamma Knife Radiosurgery for Brain Tumors and Arteriovenous and Cavernous Malformations
•  [859] Gamma Knife Radiosurgery
•  [960] Gamma Knife plus whole brain radiotherapy versus gama knife alone study for patients with brain metastasis
•  [961] Chemosensitivity assay for malignant brain tumors
•  [962] Gene Therapy Of Malignant Gliomas: A Pilot Study of Vaccination With Autologous Glioma-Lysate And Dendritic Cells Admixed With IL-4 Transduced Fibroblasts To Elicit An Immune Response.
•  [968] Accelerated Radiotherapy and Temodar in Adults with Newly Diagnosed Glioblastoma Multiforme - a Pilot Study
•  [1012] Evaluation of CPT-11 (Irinotecan) in chemonaive patients with inoperable brain metastases from non-small cell lung cancer
•  [1013] Temazolamide for the treatment of recurrent meningioma
•  [1016] Frameless Computer Assisted Stereotactic Surgery for Resection of Brain Tumors in Adults and Children
•  [1017] Frameless Computer Guided Stereotactic Sugery for Resection of Brain Tumors in Adults and Children
•  [1020] A Phase II Study of BCNU in Combination with Pentoxifyline for Patients with Newly Diagnosed Glioblastoma Multiforme
•  [1022] Gamma Knife Radiosurgery for Brain Tumors
•  [1035] Phase I Brachytherapy Dose Escalating Study Using the Proxima Therapeutics, Inc. GliaSIte RTS in Patients with Recurrrent Malignant Gliomas
•  [1085] TREATMENT OF NEWLY DIAGNOSED, HIGH-GRADE, MALIGNANT GLIOMA WITH POLIFEPROSAN 20 CONTAINING CARMUSTINE IMPLANT (GLIADEL® WAFER) USING MR SPECTROSCOPY DATA AS A PRIMARY INDICATOR OF THERAPEUTIC RESPONSE
•  [1090] Phase I Study of Stereotactic Radiosurgery or Fractionated Stereotactic Radiotherapy for Newly-Diagnosed or Recurrent Brain Tumors in Children < 3 years old
•  [1092] Gamma Knife Radiosurgery
•  [1102] A Pilot Trial of Low-Dose Cyclophosphamide Given Daily for Children with Recurrent or Progressive Brain Tumors
•  [1115] Phase II Trial of Tumor Lysate-Pulsed Dendritic Cell Immunotherapy for Patients with Atypical or Malignant, Primary or Metastatic Brain Tumors of the Central Nervous System
•  [1123] Fractionated Stretactic Radiotherapy Boost with weekly Paclitaxel in malignant gliomas.
•  [1124] Fractionated Streotactic Rdaiotherapy boost and Temozolamide in malignant Gliomas
•  [1125] Fractionated stretactic Radiotherapy for base of skull benigne lesions
•  [1126] Streotactic Radiosurgery for brain lesions
•  [1127] Brain Mapping for Brain Tumors
•  [1129] The use of the Gliasite radiation therapy system for malignant gliomas
•  [1130] Gamma knife stereotactic radiosurgery for benign and malignant brain tumors and brain metastases.
•  [1158] Phase I Study Of Pioglitazone And Isotretinoin In Patients With Recurrent Or Progressive Malignant Gliomas
•  [1164] Pilot Study of Bevacizamab in Patients with Recurrent or Progressive Primary Brain Tumors
•  [1243] Phase II treatment with Irinotecan (CPT-11) plus Celebrex® of adults with primary malignant glioma.
•  [1244] Phase II treatments with Temodar® for adults with progressive,resistant or recurrent meningioma.
•  [1245] Phase II treatment with Temodar for patients with newly diagnosed, progressive or recurrent primary central nervous system lymphoma.
•  [1246] Phase I/II trial of Temodar and escalating doses of Oral VP-16 for patients with recurrent malignant gliomas.
•  [1250] Phase I trial of Temodar plus O6-Benzylguanine plus Irinotecan (CPT-11) in the treatment of patients with recurrent/progressive Cerebral anaplastic gliomas.
•  [1253] Phase II trial of Temodar ® plus O6-Benzylguanine in the treatment of patients with Temodar® -resistant malignant glioma.
•  [1255] Pilot study of genetic and environmental Risk and outcome for newly diagnosed brain tumor patients and controls.
•  [1260] Phase III randomized trial of the role of Whole Brain Radiation Therapy in addition to Radiosurgery in the management of patients with one to three cerebral metastases.
•  [1261] Pilot trial of Innohep (Tinzaparin) Low Molecular Weight Heparin for primary prophylaxis of venous thromboembolism in brain tumor patients.
•  [1263] Phase II study of VNP40101M for the treatment of adults with newly diagnosed or recurrent malignant glioma.
•  [1264] Phase II trial of Gleevec plus hydroxyurea in the treatment of patients with malignant glioma
•  [1265] Phase I, open-label, 2-arm dose escalation study of Imatinib Mesylate (Gleevec) in combination with Temozolomide (Temodar)in patients with glioblastoma multiforme and gliosarcoma.
•  [1266] Phase I trial of Oral Topotecan plus Temodar in the treatment of patients with recurrent/progressive malignant gliomas.
•  [1269] Phase I study of Gefitinib plus Rapamycin for patients with recurrent malignant glioma.
•  [1270] Activation of A Pilot Comparison Bioavailability Study of Oral and Intravenously Administered Temozolomide (Temodar) in patients with primary CNS malignancies.
•  [1271] Phase I/II trial of ZD1839 (Iressa) in pediatric patients newly diagnosed with brain stem tumors or incompletely resected supratentorial malignant gliomas.
•  [1272] Pilot study of systemic and intrathecal chemotherapy followed by conformal radiation for infants with embryonal intracranial central nervous system tumors.
•  [1275] Pilot study of Irinotecan (CPT-11) given concurrently with 76 Gy of conformal multiple fraction per day External Beam Radiotherapy followed by Maintenance Therapy with BCNU plus Irinotecan (CPT-11) for newly diagnosed diffuse pontine glioma.
•  [1276] Phase I treatment with Irinotecan (CPT-11) plus Temozolomide (Temodar) of children with primary recurrent malignant brain tumors.
•  [1277] Phase I trial of Temozolomide (Temodar) and O6-Benzylguanine (o6-bg)in pediatric patients with recurrent brain tumors.
•  [1278] Phase II study of Oxaliplatin in children with recurrent or refractory medulloblastoma, supratentorial primitive neuroectodermal tumors and atypical teratoid rhabodoid tumors.
•  [1279] Phase I study of Cilengitide in children with refractory brain tumors.
•  [1280] Pharmacological intervention for learning impaired children surviving treatment for cancer.
•  [1282] Quality of Life Studies (There are 19 seperate studies listed here)
•  [1337] Fractionated stereotactic radiotherapy for the treatment of acoustic neuromas, meningiomas and metastatic brain tumors.
•  [1349] A Phase I/II Study of Anti-Angiogenesis Therapy for Atypical and/or Unresectable Meningioma
•  [1473] Erlotinib and Temozolomide With Radiation Therapy in Treating Patients With Glioblastoma Multiforme or Other Brain Tumors
•  [1533] PHASE I,II STUDY OF PRE-IRRADIATION CHEMOTHERAPY WITH METHOTREXATE, RITUXIMAB, AND TEMOZOLOMIDE AND POST RADIATION TEMOZOLOMIDE FOR PRIMARY CENTRAL NERVOUS SYTEM LYMPHOMA.
•  [1534] A PHASE II STUDY OF A TEMOZOLOMIDE-BASED CHEMOTHERAPY REGIMEN FOR HIGH RISK LOW GRADE GLIOMAS
•  [1619] SWOG (RTOG) 98-13 randomized trial of RT + Temozolomide vs RT + BCNU, versus RT+ Tem + BCNU
•  [1620] Z0300: Phase III Randomized Trial of the Role of Whole Brain Radiation Therapy in Addition to Radiosurgery in the Management of Patients with One to Three Cerebral Mets
•  [1621] The use of the Gliasite radiation therapy system for malignant gliomas
•  [1622] Radiosurgery with the Varian Trilogy system for benign or malignant brain tumors
•  [1623] NCCTG Phase 2 Trial of CCI-779 (Temsirolimus) in Recurrent Glioblastoma Multiforme
•  [1625] An Open-label, Dose Confirmation and Dosimetry Study of Interstitial 131I-chTNT-1/B MAB (COTARA) for the Treatment of Glioblastoma Multiforme (GBM) at 1st of 2nd Relapse
•  [1663] A Novel Mechanism for Treating Cancer Employing Homeopathic and Bioenergetic Mechanisms of Action
•  [1666] Cilengitide (EMD 121974) for Recurrent Glioblastoma Multiforme (Brain Tumor)
•  [1667] Cilengitide and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
•  [1668] Sorafenib in Treating Patients With Recurrent or Progressive Malignant Glioma
•  [1669] Iodine I 131 Monoclonal Antibody TNT-1/B (131I MOAB TNT-1/B), in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme
•  [1670] Phase I/II Study of Concurrent Dose Escalation Temodar and Whole Brain Radiation Therapy in Patients with Multiple Brain Metastases.
•  [1671] Phase II Study Utilizing Focal Radiation in Patients with 1-3 Brain Metastases.
•  [1673] Headstart II A Phase II study of two alternative intensive induction chemotherapy followed by consolidation with myeloablative chemotherapy and autologous stem cell rescue with or without subsequent radiation therapy for children less than 10 yrs of age newly diagnosed with malignant brain tumors
•  [1674] "Head Start" chemotherapy protocol for children less than 10 years old with newly diagnosed high grade primary brain tumors with intent to eliminate irradiation and abbreviate total duration of treatment to 6 months with resultant improved cure rate and quality of survival.
•  [1747] Phase II Study of Gleevec/Imatinib Mesylate (STI-571, NSC 716051) in Neurofibromatosis (NF1) Patients with Plexiform Neurofibromas
•  [1763] Phase II Study of Temozolomide in Newly Diagnosed Glioblastoma in elderly ( over 69 years old) Patients
•  [1772] Identification of factors associated with brain metastasis in women with breast cancer: development of a predictive nomogram
•  [1773] Identification of Hypermethylated Serum Tumor DNA in High Grade Glioma Patients and Correlation with Magnetic Resonance Imaging Findings
•  [1774] Open-label, Dose Confirmation and Dosimetry Study of Interstitial 131-I chTNT-1/B mAb (Cotara®) for the Treatment of Recurrent Glioblastoma Multiforme (GBM)
•  [1776] Gliadel and Dendritic Cell Vaccine for Malignant Glioma
•  [1777] A Phase II Trial of Dendritic Cell Vaccine Pulsed with Tumor Lysate Followed by Temozolomide Upon Recurrence in Patients with Newly Diagnosed Glioblastoma
•  [1778] Improving Quality Of Life For Brain Tumor Patients
•  [1815] NABTC0701: Phase I Trial of Aflibercept (VEGF Trap)with Radiation Therapy and Concomitant and Adjuvant Temozolomide in Patients With Malignant Gliomas
•  [1834] High dose erlotinib for recurrent/residual GBM; Correlation of response to EGFRvIII and PTEN status
•  [1863] 2006-0472: Phase I/II Trial of Irinotecan plus Lenalidomide in Adult Patients with Recurrent Glioblastoma Multiforme
•  [1864] A Phase II trial of RAD001 in patients with recurrent glioblastoma multiforme (Study # CRAD001C2410
•  [1865] Study of a Drug [DCVax®-Brain] to Treat Newly Diagnosed GBM Brain Cancer
•  [1866] Phase I Study of Multi-modality Treatment for Patients with Newly Diagnosed Glioblastoma Multiforme Using Concurrent Gliadel Wafers and Permanent I-125 Seeds
•  [1867] A Multicenter Prospective Analysis of Treatment Outcomes in Patients with Large Acoustic Neuromas Receiving Subtotal Resection with Back up Stereotactic Radiation Therapy
•  [1870] Gliogene: An International Brain Tumor Study
•  [1885] A Phase 2 Study of XL184 in Subjects with Progressive or Recurrent Glioblastoma Multiforme in First or Second Relapse
•  [1889] BIBW 2992 with or without daily temozolomide in the treatment of patients with recurrent malignant glioma
•  [1894] Quality of Life in Patients with Brain Tumors, Skull Base Tumors & Pituitary Adenomas Undergoing Surgical Resection
•  [1897] A Pilot Study to Evaluate the Effects of Vaccinations with HLA-A2-Restricted Glioma Antigen-Peptides in Combination with Poly-ICLC for Children with Newly Diagnosed Malignant or Intrinsic Brain Stem Gliomas (BSG) or Incompletely Resected Non-Brainstem High-Grade Gliomas (HGG) or Recurrent Unresectable Low-Grade Gliomas (LGG) or Recurrent High Grade Gliomas
•  [1898] 2008-0059: Phase I/II study of sorafenib with radiation and temozolomide in newly diagnosed glioblastoma or gliosarcoma
•  [1909] A Multicenter Prospective Analysis of Treatment Outcomes in Patients with Large Acoustic Neuromas Receiving Subtotal Resection with Back up Stereotactic Radiation Therapy
•  [1910] ID01-310: Phase I Trial of Conditionally Replication-Competent Adenovirus (Delta-24-RGD4C) for recurrent malignant glioma
•  [1923] Radiation Therapy and Stereotactic Radiosurgery With or Without Temozolomide or Erlotinib in Treating Patients With Brain Metastases Secondary to Non-Small Cell Lung Cancer
•  [1928] Phase II Clinical Trial of Hyperbaric Oxygenation in Conjunction with Radiotherapy and Temozolomide in Adults with Newly Diagnosed Glioblastoma
•  [1942] A PHASE II STUDY OF GLIADEL, CONCOMITANT TEMOZOLOMIDE AND RADIATION, FOLLOWED BY DOSE DENSE THERAPY WITH TEMOZOLOMIDE PLUS BEVACIZUMAB FOR NEWLY DIAGNOSED MALIGNANT HIGH GRADE GLIOMA
•  [1943] A Phase I/II Study of Patients with Newly Diagnosed Primary Central Nervous System Lymphoma Treated with Methotrexate/BBBD, and Adding Rituximab (an anti CD-20 Antibody) and Carboplatin to the Treatment Regimen
•  [1944] Phase I/II Study of Carboplatin, Melphalan and Etoposide Phosphate in Conjunction with Osmotic Opening of the Blood-Brain Barrier and Delayed Intravenous Sodium Thiosulfate Chemoprotection, in Subjects with Anaplastic Oligodendroglioma or Oligoastrocytoma
•  [1945] Phase II Clinical Trial of Patients with High-Grade Glioma Treated with Intra-arterial Carboplatin-based Chemotherapy, Randomized to Treatment with or without Delayed Intravenous Sodium Thiosulfate as a Potential Chemoprotectant against Severe Thrombocytopenia
•  [1946] 2008-0318: Phase I/II trial of Dasatinib (Sprycel) with Radiation Therapy and concomitant and Adjuvant Temozolomide in Patients with newly diagnosed Glioblastoma
•  [1947] 2009-0476: A Phase I dose-finding study of XL184 administered orally in combination with Temozolomide and Radiation Therapy in first line treatment of glioblastoma
•  [1949] BTTC08-01: Phase II Post-RT/TMZ Bevacizumab and Erlotinib for newly GBM without MGMT promoter methylation
•  [1950] NABTC04-03: Phase I study of Vorinostat (SAHA) in combination with temozolomide in patiesnts with malignant gliomas
•  [1952] 2009-0651: Phase I/II adaptive randomized trial of vorinostat, erlotinib and carboplatin in adults with recurrent glioblastoma
•  [1978] 2006-0709: Phase I / II Adaptive Randomized Trial of Vorinostat, Isotretinoin and Carboplatin in Adults with Recurrent Glioblastoma Multiforme
•  [1979] 2009-0548: A Phase I Study of MK-0752, a Notch Inhibitor, in Patients With recurrent glioma
•  [1980] 2009-0597: Randomized Phase II Trial of Standard Dose Bevacizumab Versus Low Dose Bevacizumab plus Lomustine (CCNU) In Adults with Recurrent Glioblastoma Multiforme
•  [1996]
•  [2004] A Phase 2a Study of AdV-tk + Valacyclovir Gene Therapy in Combination With Standard Radiation Therapy for Malignant Glioma
•  [2005] A Phase 1b Study of AdV-tk + Valacyclovir Gene Therapy in Combination With Standard Radiation Therapy for Malignant Gliomas
•  [2006] A Phase II Study of Gliadel, Concomitant Temozolomide and Radiation, followed by Dose Dense Therapy with Temozolomide Plus Bevacizumab (Avastin) for Newly Diagnosed Malignant High Grade Gliomas
•  [2008] RTOG 0825 Phase III Double-Blind Placebo-Controlled Trial of Conventional Concurrent Chemoradiation and Adjuvant Temozolomide Plus Bevacizumab versus Conventional Concurrent
•  [2009] BTTC08-01: Phase II Post-RT/TMZ Bevacizumab and Erlotinib for newly GBM without MGMT promoter methylation
•  [2010] Meningioma: Risk Factors and Quality of Life
•  [2011] Evaluating the Feasibility of Real-Time, Magnetic Resonance Thermal Imaging and Magnetic Resonance Imaging (MRI)-Guided Laser Induced Thermal Therapy (LITT) for the Treatment of Metastatic Brain Tumors
•  [2012] Molecular Biology of Central Nervous System (CNS) Tumors
•  [2024] 2009-0759: A Phase 2 Open-Label Study of TPI 287 in Patients with Glioblastoma Multiforme That Has Recurred or Progressed Following Prior Therapy with Radiation plus Temozolomide
•  [2025] CERN 08-02: A Phase II Study of Dose-Dense Temozolomide and Lapatinib for Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial and Spinal Cord Ependymoma
•  [2026] CERN 09-02: Phase II trial of carboplatin and bevacizumab for the treatment of recurrent low-grade and anaplastic supratentorial, infratentorial and spinal cord ependymoma in adults
•  [2027] RTOG 0539: Phase II Trial of observation for low-risk meningiomas and of radiotherapy for intermediate and high-risk meningiomas
•  [2028] RTOG 0834: Phase III trial on Concurrent and Adjuvant Temozolomide chemotherapy in non - 1p/19q deleted anaplastic glioma. The CATNON Intergroup trial.
•  [2037] A Phase 2 Study of Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Malignant Tumors of the Brain
•  [2038] N0874/ABTC09-02: Phase I/II Study of Vorinostat (Suberoylanilide Hydroxamic Acid [SAHA]), Temozolomide, and Radiation Therapy in Patients with Newly Diagnosed Glioblastoma
•  [2039] A Phase I Ascending Dose Trial of the safety and Tolerability of Toca-511 in Patients with Recurrent Glioblastoma Multiforme
•  [2041] A Phase II study of BKM120 for patients with recurrent glioblastoma and activated PI3K pathway at first relapse
•  [2042] Plexxicon, Inc - A Phase 2 Study of Orally Administered PLX3397 in Patients With Recurrent Glioblastoma
•  [2063] An International, Randomized, Double-Blind, Controlled Study of Rindopepimut/GM-CSF with Adjuvant Temozolomide in Patients with Newly Diagnosed, Surgically Resected, EGFRvIII-positive Glioblastoma(The “ACT IV” Study)
•  [2064] Protocol H9H-MC-JBAI - Phase 1b/2a Study Combining LY2157299 with Standard Temozolomide-based Radiochemotherapy in Patients with Newly Diagnosed Malignant Glioma
•  [2065] A Phase I Dose Escalation Study of Hypofractionated Stereotactic Radiotherapy with Bevacizumab in the Treatment of Recurrent Malignant Glioma
•  [2066] Protocol H9H-MC-JBAL- A Phase 2 Study of LY2157299 Monohydrate Monotherapy or LY2157299 Monohydrate plus Lomustine Therapy compared to Lomustine Monotherapy in Patients with Recurrent Glioblastoma
•  [2067] A Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase II Study Evaluating the Efficacy and Safety of Onartuzumab in Combination with Bevacizumab or Onartuzumab Monotherapy in Patients with Recurrent Glioblastoma
•  [2050] A Study of Rindopepimut/GM-CSF in Patients With Relapsed EGFRvIII-Positive Glioblastoma (ReACT)
•  [2051] Phase III Study of Rindopepimut/GM-CSF in Patients With Newly Diagnosed Glioblastoma (ACT IV)
•  [2055] Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade Glioma
•  [2056] Study of a Drug [DCVax®-Brain] to Treat Newly Diagnosed GBM Brain Cancer
•  [1981] RTOG 0825 Phase III Double-Blind Placebo-Controlled Trial of Conventional Concurrent Chemoradiation and Adjuvant Temozolomide Plus Bevacizumab versus Conventional Concurrent
•  [1881] Phase I/II Trial of Imatinib Mesylate; (Gleevec; ST1571) in Treatment of Recurrent Oligodendroglioma and Mixed Oligoastrocytoma
•  [1882] Erlotinib and Temozolomide With Radiation Therapy in Treating Patients With Glioblastoma Multiforme or Other Brain Tumors
•  [1884] Phase I/II Study of ZD6474 (ZactimaTM) With Radiation Therapy and Concomitant and Adjuvant Temozolomide in Patients With Newly-Diagnosed Glioblastoma

Inactive Trials

Note - these mighe be duplicates, or closed trials

•  [47] Phase 1 study of chemotherapy with CY/VP 16/ high dose CBDCA plus autologous bone marrow rescue in patients with refractory primary CNS malignancies or Solid Tumors
•  [76] Phase 1 Pilot Study of Pre-operative Radiotherapy Plus Surgery in Patients with Supratentorial Grade 3/4 Astrocytoma. (AA / GBM)
•  [80] Phase 1/2 Focal External Beam Dose Escalation Protocol to Determine the MTD of 3-D Conformal Therapy and The Duration of Local Control, Patterns of Recurrence and Toxicity
•  [81] Phase 3 Study of Stereotactic 125I Brachytherapy in Conjunction with Fractionated External Beam Radiation for Supratentorial Malignant Astrocytomas
•  [105] Phase 1 Study of Small Field Stereotactic External Beam Irradiation in Patients with Recurrent Primary Brain Tumors or CNS Metastases.
•  [109] Phase 3 Comparison of Surgery And External Beam Radiotherapy Combined With IV BCNU VS. IV BCNU + Intraarterial CDDP in Patients With Malignant Glioma
•  [168] Multiple light fiber interstitial photodynamic therapy for brain tumors
•  [179] Phase 3 Study of Radiosurgery in the Therapy of Patients With Newly Diagnosed Glioblastoma Multiforme
•  [182] Phase 2 Study Of Correlation of Tumor Interferon Alpha Gene Status With Response To High Dose Interferon Alpha in the Treatment of Patients with Glioblastoma Multiforme, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma, And Anaplastic Mixed Astrocytoma
•  [183] Phase 1/2 Analysis of Combined Radiosurgery And Intra-Arterial Cisplatin in the Treatment of Patients With Recurrent Glioblastoma Multiforme, Gliosarcoma, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma And Anaplastic Mixed Astrocytoma
•  [185] Phase 3 Study of Accelerated Hyper-Fractionate Radiation in the Treatment of Patients With Newly Diagnosed Metastatic Brain Tumor.
•  [221] Phase I Trial of Gamma Knife Treatment For Acoustic Neuromas
•  [222] Phase 1 Trial Of Gamma Knife For Brain Metastases
•  [225] High dose chemo for resistant or recurrent brain tumors in children and young adults up to age 25
•  [267] Phase 3 randomized placebo controlled trial of Gliadel wafers implantation at primary surgery for malignant gliomas.
•  [291] Boron Neutron Capture Therapy
•  [319] Fractionated stereotactic radiosurgery (FSR) for brain tumors. Johns Hopkins has pioneered the development of FSR for the treatment of acoustic neuromas, meningiomas, pituitary tumors, brain metastases, pineal tumors, craniopharyngiomas and others. Please contact Dr. Jeffery Williams by phone 410-614-2886, fax 410-614-2982 and email jw@jhu.edu
•  [335] Phase I/II Evaluation Of CI-980 For The Treatment Of Recurrent Or Progressive Malignant Gliomas
•  [339] Phase 1b Study Of Stereotactic Radiosurgery And Etanidazole For The Treatment Of Recurrent Primary Brain Tumors Or CNS Mets
•  [341] Phase 2 Study Of Suramin In The Treatment Of Recurrent Or Progressive Malignant Glioma
•  [352] Phase 3 Randomized Trial Of Standard Vs. Dose Intensified Chemotherapy Followed By Radiation For Pediatric Brain Tumors
•  [383] Phase II Study of Octreotide For Meningioma And Meningeal Hemangiopericytoma
•  [387] Phase II Study of Interstitial Thermoradiotherapy for Newly Diagnosed and Recurrent Malignant Intracranial Tumors
•  [393] Intra-arterial Chemotherapy Given In Conjunction With Hyperosmotic Blood-Brain Barrier Disruption For Primary Brain Tumors And For Some Categories Of Metasatic Brain Tumors
•  [394] Liposomal Doxorubicin For Primary Brain Tumors
•  [409] New trend in management of malignant brain tumor through tumour inhibitory factors
•  [531] A phase I trial of surgery, Gliadel and Carboplatin in combination with radiation therapy for anaplastic astrocytoma or glioblastoma Multiforme
•  [534] Pilot study of combination Temozolomide (Temodal) and 6-Thioguanine chemotherapy for patients with recurrent malignant gliomas
•  [626] Phase I Trial and pharmacokinetic study of Temozolomide and O6-Benzylguanine in childhood solid tumors.
•  [734] A Phase I/II Trial of SU5416 in Patients with Recurrent High Grade Astrocytomas or Mixed Gliomas
•  [740] NABTT Trial: A Phase I, Open Label, Dose-Escalation, Trial of Intratumor Injection iwth an E1B-Attenuated Adenovirus, Onyx-015, into Recurrent Malignant Glioma
•  [814] Phase I/II trial of Oxaliplatin as Neoadjuvant Treatment in Adults with Newly Diagnosed GBM
•  [846] Phase II Trial of Oxaliplatin as Neoadjuvant Treatment in Adults with Newly Diagnosed Glioblastoma Multiforme
•  [853] A Phase I, Open Label, Dose Escalation Trial of Intratumoral Injectin with E1B-Attenuated Adenovirus (Active an UV-Inactivated), Onyx-015, into Recurrent Malignant Gliomas
•  [855] Interstitial Infusion of IL13-PER38QQR Cytotoxin in Recurrent Malignant Glioma: Phase I/II Study
•  [883] Phase I/II Trial of Oxaliplatin as Neoadjuvant Treatment in Adults with Newly Diagnosed Malignant Glioma
•  [1031] Phase I/II Trial of Oxaliplatin as Neoadjuvant TX in adults newly diagnosed GBM
•  [1038] Phase I Evaluation of the Safety of PS 341 in the treatment of Recurrent Gliomas
•  [1059] Phase I/II Trial of Oxaliplatin as Neoadjuvant Treatment in Adults with Newly Diagnosed Glioblastoma Multiforme
•  [1069] Phase II Trial of Continuous Dose Temozolomide in Patients with Newly Diagnosed Anaplastic Oligodendroglioma and Mixed Oligoastrocytoma
•  [1076] Phase I Brachytherapy Dose Escalating Study Using the Proxima Therapeutics, Inc GliaSite RTS in Patients with Recurrent Malignant Gliomas
•  [1079] A Pharmacokinetic Study of the Interaction Between Celecoxib and Anticonvulsant Drugs in Patients with Newly Diagnosed Glioblastoma Multiforme Undergoing Radiation Therapy
•  [1084] Phase II Trial of Temozolomide (Temodar) in Patients with Newly Diagnosed Anaplastic Oligo (AO) & Mixed Oligoastrocytoma (MAO)
•  [1096] A Phase I/II Trial of BMS-247550 for Treatment of Patients with Recurrent High-Grade Gliomas (NABTT 2111)
•  [1109] SWOG (RTOG) 98-13 randomized trial of RT + Temozolomide vs RT + BCNU, versus RT+ Tem + BCNU
•  [1119] Combination of 6-Thioguanine, Capecitabine, Celecoxib and Temozolomide or CCNU for Recurrent Anaplastic Glioma
•  [1167] A Phase I/II Study to Evaluate the Safety and Tolerance of Escalating Doses of RSR13 Administered with a Fixed Dose of BCNU Every Six Weeks in Patients with Recurrent Malignant Glioma
•  [1257] Phase I/II, two-arm, multicenter, dose escalation study of Oral AEE788 administered on a continuous once daily dosing schedule in adult patients with recurrent or relapsing glioblastoma.
•  [1258] Phase I/II, two-arm, multicenter, dose escalation study of Oral AEE788 administered on a continuous once daily dosing schedule in adult patients with recurrent or relapsing glioblastoma.
•  [1311] Phase I Brachytherapy Dose Escalating Study USing the Proxima Therapeutics, Inc. GliaSIte RTS in Patients with Recurrrent Malignant Gliomas
•  [1476] Intratumoral Transferrin-CRM107 Compared With Best Standard Chemotherapy in Treating Patients With Progressive and/or Recurrent Glioblastoma Multiforme
•  [1493] Erlotinib in Treating Patients With Recurrent Malignant Glioma or Recurrent or Progressive Meningioma
•  [1506] Phase I/II Trial of R115777 and XRT in Pediatric Patients with Newly Diagnosed Non-Disseminated Intrinsic Diffuse Brainstem Gliomas
•  [1617] ABT-751 in Treating Young Patients With Refractory Solid Tumors
•  [1626] A phase I/II Evaluation of Vaccination with Type-1 Dendritic Cells Pulsed With Multiple Peptides In the Treatment of HLA-A2 Positive Patients With Recurrent Malignant Gliomas
•  [1662] Phase I/II trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine For Patients With Recurrent High Grade Glioma
•  [1676] ABTC 04-03: A Phase I Study of Vorinostat (Suberolyanilide Hydroxamic Acid [SAHA]) in Combination with Temozolomide in Patients with Malignant Gliomas
•  [1749] ABTC05-02 - Phase I/II Studies of BAY 43-9006 (sorafenib) in Combination with OSI-774 (erlotinib), R115777 (tipifarnib) or CCI-779 (temsirolimus) in Patients with Recurrent Glioblastoma Multiforme or Gliosarcoma.
•  [1850] Phase I/II Study of OSI-774 (Erlotinib) and CCI-779 (Temsirolimus) in Patients with Recurrent Malignant Glioma
•  [1851] Phase I / II Adaptive Randomized Trial of Vorinostat, Isotretinoin and Carboplatin in Adults with Recurrent Glioblastoma Multiforme
•  [1852] A Randomized Phase II Trial of Bevacizumab With Irinotecan or Bevacizumab With Temozolomide in Recurrent Glioblastoma
•  [1854] 2007-0491: Phase 2, 2-part, multicenter, open-label study to evaluate the safety, tolerability, and efficacy of CT-322 (Angiocept™) monotherapy and combination therapy with irinotecan in patients with recurrent glioblastoma multiforme
•  [1855] A Phase II Trial of Thalidomide in combination with Temozolomide or CPT-11 in patients with recurrent anaplastic gliomas or glioblastoma multiforme
•  [1856] Phase I/II Study of Temozolomide and Intrathecal DepoCyt in Patients with Neoplastic Meningitis
•  [1862] Phase 1, Open-Label, Dose Escalation Study of ANG1005 in Patients with Malignant Glioma
•  [1891] Phase I study of MPC-6827 in combination with carboplatin for recurrent glioblastoma
•  [1899] Phase II study of CDX-110 with radiation and temozolomide in patients with newly diagnosed glioblastoma multiforme
•  [1900] Phase III, randomised, parallel Group, multi-centre study in recurrent glioblastoma patients to compare the efficacy of cediranib monotherapy and the combination of cediranib with lomustine to the efficacy of lomustine alone
•  [1901] 2007-0532: Phase III double blind, placebo controlled study of donepezil in irradiated brain tumor patients
•  [1935] Phase I/II Trial for Patients with Recurrent Resectable Glioblastoma Multiforme Using Surgery with Implantable BCNU Polmer Followed by Post-operative Irinotecan and Bevacizumab
•  [1936] A phase II trial of PTK-787 in recurrent or progressive meningiomas
•  [1937] RTOG 0614 A Randomized, Phase III, Double-Blind, Placebo-Controlled Trial of Memantine for Prevention of Cognitive Dysfunction in Patients Receiving Whole-Brain Radiotherapy
•  [1938] RTOG 0825 Phase III Double-Blind Placebo-Controlled Trial of Conventional Concurrent Chemoradiation and Adjuvant Temozolomide Plus Bevacizumab versus Conventional Concurrent
•  [1948] 2004-0662: Randomized, factorial-design, Phase II trial of Temozolomide alone and in combination with possible permutations of Thalidomide, Isotretinoin and/or Celecoxib as post-radiation adjuvant therapy of glioblastoma
•  [1951] 2009-0576: Phase I evaluation of SCH900105 with correlative tissue studies in the treatment of adult patients with recurrent glioblastoma
•  [1953] 2007-0816: Phase 2 Study of XL184 in Subjects with Progressive or Recurrent Glioblastoma Multiforme in First or Second Relapse
•  [1963] Phase II Trial of Dasatinib in Patient with Recurrent Glioblastoma Multiforme
•  [1964] CERN08-02 - A Phase II Study of Dose-Dense Temozolomide and Lapatinib for Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial and Spinal Cord Ependymoma
•  [1965] Phase II Study of Gamma-Knife Radiosurgery Using Magnetic Resonance Spectroscopy for Target Definition in Patients with Recurrent Glioma
•  [1982] ABTC09-04 - A Biomarker and Phase II Study of GDC-0449 in Patients with Recurrent Glioblastoma Multiforme
•  [1983] A Phase I Study of MK-0752, a Notch Inhibitor, in Patients With Metastatic or Locally Advanced Breast Cancer and Other Solid Tumors
•  [2007] A PHASE II STUDY OF GLIADEL, CONCOMITANT TEMOZOLOMIDE AND RADIATION, FOLLOWED BY DOSE DENSE THERAPY WITH TEMOZOLOMIDE PLUS BEVACIZUMAB FOR NEWLY DIAGNOSED MALIGNANT HIGH GRADE GLIOMA
•  [2040] ABTC1002 - A Phase I/II Study of RO4929097 with Bevacizumab in Patients with Recurrent Malignant Glioma
•  [1905] Study of a Drug [DCVax®-Brain] to Treat Newly Diagnosed GBM Brain Cancer
•  [1906] A Phase II trial of RAD001 in patients with recurrent glioblastoma multiforme (Study # CRAD001C2410
•  [1904] Phase II Study of CDX-110 in Patients With Glioblastoma Multiforme (GBM) (ACT III)