Oligodendroglioma High Grade
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Trials and Noteworthy Treatments

  Treatment Location Last Updated
Details Phase I/II Trial of Irinotecan plus Lenalidomide in Adult Patients with Recurrent Glioblastoma Multiforme Houston, TX 05/28/2008
Details Phase 1, Open-Label, Dose Escalation Study of ANG1005 in Patients with Malignant Glioma Houston, TX 05/28/2008
Details A Phase II Trial of Thalidomide in combination with Temozolomide or CPT-11 in patients with recurrent anaplastic gliomas or glioblastoma multiforme Houston, TX 04/16/2008
Details A Phase I Dose-Finding and Pharmacokinetic Study of Intravenous RTA 744 Injection in Patients with Recurrent or Refractory Glioma, with or without Concurrent Treatment with Enzyme-Inducing Anticonvulsant Drug Therapy. Houston, TX 04/15/2008
Details Phase I / II Adaptive Randomized Trial of Vorinostat, Isotretinoin and Carboplatin in Adults with Recurrent Glioblastoma Multiforme Houston, TX 04/15/2008
Details Phase I/II Study of OSI-774 (Erlotinib) and CCI-779 (Temsirolimus) in Patients with Recurrent Malignant Glioma Houston, TX 04/15/2008
Details A Phase I Study of Vorinostat [Suberoylanilide Hydroxamic Acid (SAHA)] in Combination with Temozolomide in Patients with Malignant Gliomas Los Angeles, CA
Boston, MA
Bethesda, MD
Durham, NC
New York, NY
Houston, TX
04/15/2008
Details Combination of 6-Thioguanine, Capecitabine, Celecoxib and Temozolomide or CCNU for Recurrent Anaplastic Glioma Houston, TX 04/15/2008
Details Phase I and II, Open-Label, Multi-Center Trials of Pazopanib in Combination with Lapatinib in Adult Patients with Relapsed Malignant Glioma Los Angeles, CA
Bethesda, MD
Durham, NC
New York, NY
Pittsburgh, PA
Houston, TX
San Antonio, TX
Madison, WI
04/15/2008
Details Phase II Single Arm Trial of VEGF Trap in Patients With Recurrent Temozolomide-Resistant Malignant Gliomas Los Angeles, CA
San Francisco, CA
Boston, MA
Bethesda, MD
Durham, NC
New York, NY
Pittsburgh, PA
Houston, TX
San Antonio, TX
Madison, WI
04/15/2008
Details Phase I Dose Escalation Study of Autologous Tumor Lysate-Pulsed Dendritic Cell Immunotherapy for Malignant Gliomas in Pediatric Patients Los Angeles, CA 03/02/2008
Details Phase I Study of Glioma-Associated Antigen (GAA) Peptide-Pulsed Dendritic Cell Vaccination in Malignant Glioma Patients Los Angeles, CA 03/02/2008
Details Phase I Study of Immunization With Autologous Tumor Lysate-Pulsed Dendritic Cells in Patients With Malignant Gliomas (Vaccine Therapy in Treating Patients With Malignant Glioma) Los Angeles, CA 03/02/2008
Details Phase I/II Study of GP96 Heat Shock Protein-Peptide Complex Vaccine in Patients With Recurrent or Progressive High-Grade Glioma San Francisco, CA 03/02/2008
Details Phase ll Trial of Tumor Lysate-Pulsed Dendritic Cell Immunotherapy for Patients With Atypical or Malignant, Primary or Metastatic Brain Tumors of the Central Nervous System Los Angeles, CA 03/02/2008
Details A phase I/II Evaluation of Vaccination with Type-1 Dendritic Cells Pulsed With Multiple Peptides In the Treatment of HLA-A2 Positive Patients With Recurrent Malignant Gliomas Pittsburgh, PA 03/02/2008
Details NTI 0501: An Open-Labeled, Extended-Use of Human Corticotropin-Releasing Factor (hCRF) (Xerecept) Intended for Patients Who Participate in Dexamethasone-Sparing Studies NTI 0302 or NTI 0303 Kingston, Ontario, CANADA
Edmonton, Alberta, CANADA
Halifax, Nova Scotia, Canada
Moncton, New Brunswick, CANADA
Ottawa, Ontario, CANADA
Toronto, Ontario, CANADA
Winnipeg, Manitoba, CANADA
Phoenix, AZ
La Jolla, CA
Palo Alto, CA
Sacramento, CA
Aurora, CO
Englewood, CO
Jacksonville, FL
Orlando, FL
Chicago, IL
Evanston, IL
Boston, MA
Detroit, MI
Winston-Salem, NC
Edison, NJ
Buffalo, NY
Columbus, OH
Columbus, OH
Portland, OR
Memphis, TN
Nashville, TN
Seattle, WA
Madison, WI
03/01/2008
Details Phase II Study Of 7 Days On/7 Days Off Temozolomide In Patients With High-Grade Glioma San Francisco, CA 01/17/2008
Details NABTC 04-03: A Phase I Study of Vorinostat (Suberolyanilide Hydroxamic Acid [SAHA]) in Combination with Temozolomide in Patients with Malignant Gliomas San Francisco, CA 10/03/2007
Details NABTC 04-02: Erlotinib and Temsirolimus in Treating Patients With Recurrent Malignant Glioma Los Angeles, CA
San Francisco, CA
Boston, MA
Durham, NC
New York, NY
Pittsburgh, PA
Houston, TX
San Antonio, TX
Madison, WI
10/03/2007
Details A Phase I Trial of Enzastaurin (LY317615) in Combination With Carboplatin in Adults With Recurrent Gliomas Bethesda, MD 08/26/2007
Details A Phase I/II Study of ATN-161 and Carboplatin in Adult Patients With Recurrent Intracranial Malignant Glioma Bethesda, MD 08/26/2007
Details Dynamic Contrast-Enhanced Magnetic Resonance Imaging With Bevacizumab (Avastin) in Combination With Irinotecan (CPT-11) for Malignant Gliomas Durham, NC 08/26/2007
Details A Phase 1/11 Study of Topotecan by Intracerebral Clysis for the Treatment of Recurrent Primary Malignant Brain Tumors NEW YORK CITY, NY 08/20/2007
Details A Phase I Study of Imatinib Mesylate (Gleevec) in Combination With Temozolomide (Temodar) in Patients With Malignant Glioma Durham, NC 08/20/2007
Details A Phase II Safety Study of Bevacizumab in Patients With Multiple Recurrent or Progressive Malignant Gliomas Chicago, IL 08/20/2007
Details Determination of the In-Tumor-Concentration of Imatinib Mesylate (Gleevec) in Malignant Glioma After Oral Administration Baltimore, MD 08/20/2007
Details Eligibility Screening Of Patients With Central Nervous System Tumors For The National Cancer Institute`s (NCI) Clinical Research Protocols Bethesda, MD 08/20/2007
Details The Temozolomide RESCUE Study: A Phase II Trial of Continuous (28/28) Dose-Intense Temozolomide (CDIT) Chemotherapy After Progression on Conventional 5/28 Day Temozolomide in Patients With Recurrent Malignant Glioma Toronto, Ontario, CANADA 08/20/2007
Details A Phase II Trial of Bevacizumab (Avastin) and Irinotecan (CPT-11) for Patients With Recurrent High-Grade Gliomas Immediately Following Tumor Progression After Treatment With Bevacizumab Alone Bethesda, MD 08/19/2007
Details A Phase II Trial of BEVACIZUMAB for Patients with Recurrent High-Grade Gliomas Bethesda, MD 08/18/2007
Details A Phase II Trial With Bevacizumab (Avastin) and Irinotecan (CPT-11) for Patients With Primary Brain Tumors and Progression After Standard Therapy Copenhagen, Denmark 08/18/2007
Details Combination of 6-Thioguanine, Capecitabine, Celecoxib and Temozolomide or CCNU for Recurrent Anaplastic Glioma and Glioblastoma Multiforme Houston, TX 08/18/2007
Details Identification of Hypermethylated Serum Tumor DNA in High Grade Glioma Patients and Correlation with Magnetic Resonance Imaging Findings Cleveland, OH 08/18/2007
Details Phase I study of Gefitinib plus Rapamycin for patients with recurrent malignant glioma. Los Angeles, CA
Durham, NC
08/18/2007
Details A Phase II Trial to Evaluate the Effect of Low Dose Temozolomide (TMZ) for 2 Weeks (Pre-Surgery) on Brain Tumor O-6-Methylguanine-DNA Methyltransferase (MGMT) Activity in Patients With Gliomas. Montreal, Canada 08/18/2007
Details Brain Mapping for Brain Tumors Boston, MA 08/18/2007
Details Functional image guided removal of brain tumors Manhasset, NY 08/18/2007
Details A Phase II Study of Temozolomide and O6-Benzylguanine (O6-BG) in Patients With Temozolomide-Resistant Anaplastic Glioma Los Angeles, CA 08/04/2007
Details Evaluation of a Stress Reduction Program in Patients With Malignant Brain Tumors and Their Family Caregivers Cleveland, OH 05/01/2007
Details Phase I and II, Open-Label, Multi-Center Trials of Pazopanib in Combination With Lapatinib in Adult Patients With Relapsed Malignant Glioma Tampa, FL
Atlanta, GA
Chicago, IL
Boston, MA
Detroit, MI
Durham, NC
Cleveland, OH
05/01/2007
Details Phase I Evaluation of Sodium Stibogluconate in Combination With Interferon a-2b for Solid Tumors, Lymphoma or Myeloma Cleveland, OH 05/01/2007
Details Phase I/II Study of Intravenous Infusion of Tetra-o-Methyl Nordihydroguaiaretic Acid (EM-1421) in Subjects With Recurrent High Grade Glioma Birmingham, AL
Tampa, FL
Atlanta, GA
Boston, MA
Baltimore, MD
Detroit, MI
Winston-Salem, NC
Cleveland, OH
Philadelphia, PA
05/01/2007
Details Phase II Trial of Continuous Dose Temozolomide in Patients With Newly Diagnosed Pure and Mixed Anaplastic Oligodendroglioma Cleveland, OH 05/01/2007
Details Sorafenib in Treating Patients With Recurrent or Progressive Malignant Glioma Birmingham, AL
Tampa, FL
Boston, MA
Baltimore, MD
Detroit, MI
Detroit, MI
Winston-Salem, NC
Philadelphia, PA
05/01/2007
Details Phase II Randomized Study of Intra-Arterial Carboplatin, Cyclophosphamide, and Etoposide or Etoposide Phosphate With or Without Delayed High-Dose Sodium Thiosulfate in Patients With High-Grade Glioma Cleveland, OH
Columbus, OH
Portland, OR
05/01/2007
Details Phase III Randomized Study of Radiotherapy Combined With Temozolomide Versus Carmustine in Patients With Anaplastic Astrocytoma or Mixed Gliomas Jacksonville, FL
Boston, MA
Rochester, MN
Cleveland, OH
05/01/2007
Details Phase II Study of Talampanel in Patients With Recurrent High-Grade Gliomas Bethesda, MD 04/29/2007
Details RTA 744 in Treating Patients With Recurrent or Refractory Anaplastic Astrocytoma, Anaplastic Oligodendroglioma, Anaplastic Mixed Oligoastrocytoma, Glioblastoma Multiforme, or Gliosarcoma Los Angeles, CA
Dallas, TX
11/21/2006
Details Phase I/II Trial of Oral Erlotinib (Tarceva, OSI-774) for Treatment of Relapsed/Refractory Glioblastoma Multiforme and Anaplastic Astrocytoma New York, NY 10/12/2006
Details Comprehensive Genetic Analysis Of Brain Tumors In Children. (A Non-Therapeutic Study) ,
, Canada
, Canada
, Canada
, Canada
, Canada
, Canada
, Switzerland
, Switzerland
Auckland, New Zealand
Perth, Western Australia, 6001, Australia
Randwick, New South Wales, 2031, Australia
Phoenix, AZ
Downey, CA
Loma Linda, CA
Los Angeles, CA
Los Angeles, CA
Los Angeles, CA
Madera, CA
Oakland, CA
Orange, CA
Orange, CA
Sacramento, CA
San Francisco, CA
Santa Barbara , CA
Travis Air Force Base, CA
Denver, CO
Farmington, CT
Washington, DC
Washington, DC
Wilmington, DE
Atlanta, GA
Macon, GA
Savannah, GA
Des Moines, IA
Chicago, IL
Chicago, IL
Park Ridge, IL
Indianapolis, IN
Springfield, MA
Baltimore, MD
Ann Arbor, MI
Detroit, MI
Grand Rapids, MI
Kalamazoo, MI
Royal Oak, MI
Royal Oak, MI
Minneapolis, MN
Rochester, MN
Kansas City, MO
Chapel Hill, NC
Charlotte, NC
Winston-Salem, NC
Fargo, ND
Omaha, NE
Omaha, NE
Brunswick, NJ
Newark, NJ
Paterson, NJ
Summit, NJ
Las Vegas, NV
Albany, NY
Bronx, NY
Brooklyn, NY
Brooklyn, NY
Brooklyn, NY
Brooklyn, NY
New Hyde Park, NY
New York, NY
Stony Brook, NY
Syracuse, NY
Akron, OH
Cincinnati, OH
Cleveland, OH
Columbus, OH
Dayton, OH
Toledo, OH
Portland, OR
Danville, PA
Philadelphia, PA
Pittsburgh, PA
Sioux Falls, SD
Johnson City, TN
Knoxville, TN
Nashville, TN
Amarillo, TX
Austin, TX
Dallas, TX
Houston, TX
Lubbock, TX
San Antonio, TX
San Antonio, TX
Temple, TX
Norfolk, VA
Seattle, WA
Seattle, WA
Spokane, WA
Tacoma, WA
Green Bay, WI
Green Bay, WI
Green Bay, WI
La Crosse, WI
Madison, WI
Marshfield, WI
Marshfield, WI
Huntington, WV
10/12/2006
Details Phase I/II Trial of Imatinib Mesylate; (Gleevec; ST1571) in Treatment of Recurrent Oligodendroglioma and Mixed Oligoastrocytoma Jacksonville, FL
Jacksonville, FL
Des Moines, IA
Moline, IL
Peoria, IL
Urbana, IL
Wichita, KS
Lambertville, MI
Rochester, MN
Saint Louis Park, MN
Billings, MT
Bismarck, ND
Lincoln, NE
Danville, PA
Spartanburg, SC
Sioux Falls, SD
Charlottesville, VA
06/26/2006
Details A Phase I/II Trial of ZD6474 for Patients with Recurrent High-Grade and Progressive Low-Grade Gliomas Bethesda, MD 05/29/2006
Details Pilot Randomized Study of Modafinil for Treatment of Fatigue and Neurobehavioral Dysfunction in Patients With Primary Brain Tumors Los Angeles, CA 05/29/2006
Details Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors Washington, DC
Chicago, IL
Boston, MA
Bethesda, MD
Philadelphia, PA
Pittsburgh, PA
Memphis, TN
Houston, TX
Seattle, WA
05/27/2006
Details PEG-Interferon alfa-2b With or Without Thalidomide in Treating Patients With Recurrent High-Grade Gliomas Los Angeles, CA
Boston, MA
Ann Arbor, MI
New York, NY
Pittsburgh, PA
Houston, TX
San Antonio, TX
Madison, WI
05/04/2006
Details A Phase I Trial Using Combination Irinotecan (CPT-11) and Thalidomide for Recurrent CNS Tumors Albuquerque, NM 05/02/2006
Details A Phase I/II Trial of Depsipeptide (FK228) in Patients with High-Grade Gliomas Bethesda, MD 05/01/2006
Details A Phase II Trial of Tamoxifen and Bortezomib (Velcade) in Patients with Recurrent High-Grade Gliomas Bethesda, MD 05/01/2006
Details A Pilot Study of Dronabinol for the treatment of nausea,vomiting and appetite loss in Adult Patients With Primary Gliomas Durham, NC 05/01/2006
Details Phase I/II Study of ZD6474(Zactima) in Patients With Recurrent High-Grade or Progressive Low-Grade Gliomas Bethesda, MD 05/01/2006
Details Phase II Study of Pemetrexed Disodium (Alimta) in Patients With Recurrent Malignant Gliomas, Primary CNS Lymphoma, or Brain Metastases Chicago, IL 05/01/2006
Details Pilot Study of the Safety and Accuracy of Fluorothymidine F 18 Positron Emission Tomography in Detecting Recurrent Disease in Patients With Gliomas Seattle, WA 05/01/2006
Details Headstart II A Phase II study of two alternative intensive induction chemotherapy followed by consolidation with myeloablative chemotherapy and autologous stem cell rescue with or without subsequent radiation therapy for children less than 10 yrs of age newly diagnosed with malignant brain tumors Oakland, CA 05/01/2006
Details Phase II Study of O6-Benzylguanine and Temozolomide (Temodar) in Pediatric Patients With Recurrent or Progressive High-Grade Gliomas or Brain Stem Tumors Chicago, IL
Bethesda, MD
Bethesda, MD
Durham, NC
Durham, NC
Lincoln, NE
Philadelphia, PA
Memphis, TN
Houston, TX
Seattle, WA
05/01/2006
Details Arsenic Trioxide, Temozolomide, and Radiation Therapy in Treating Patients With Malignant Glioma That Has Been Removed By Surgery Chicago, IL 04/30/2006
Details Phase II trial of Temodar ® plus O6-Benzylguanine in the treatment of patients with Temodar® -resistant malignant glioma. Durham, NC 12/03/2005
Details Pharmacological intervention for learning impaired children surviving treatment for cancer. Durham, NC 12/03/2005
Details Gamma Knife Radiosurgery Smithtown, NY 12/03/2005
Details Gamma Knife Radiosurgery for Brain Tumors La Jolla, CA 12/03/2005
Details Phase I trial of Temodar plus O6-Benzylguanine plus Irinotecan (CPT-11) in the treatment of patients with recurrent/progressive Cerebral anaplastic gliomas. Durham, NC 12/03/2005
Details Phase I trial of Temozolomide (Temodar) and O6-Benzylguanine (o6-bg)in pediatric patients with recurrent brain tumors. Durham, NC 12/03/2005
Details A Phase I dose escalation trial of Temodar that will attempt to determine the maximum tolerated dose of Temodar (Temozolomide) when given by prolonged oral exposure to children with recurrent or progressive brain tumors. New York, NY 12/03/2005
Details Fractionated Stereotactic Radiosurgery plus Topotecan radiation sensitizer in the treatment of recurrent malignant astrocytoma or as consolidation after external beam radiotherapy. New York, NY 12/03/2005
Details Gamma Knife Radiosurgery Edison, NJ 12/03/2005
Details Gamma knife stereotactic radiosurgery for benign and malignant brain tumors and brain metastases. Rockville Centre, NY 12/03/2005
Details Phase I/II Study of Multiple Light Fiber Interstitial Photodynamic Therapy for Primary and Metastatic Supratentorial Brain Tumors Hershey, PA 12/03/2005
Details Quality of Life Studies (There are 19 seperate studies listed here) Durham, NC 12/03/2005
Details Use of Epilepsy Monitoring And Electrocorticography For Seizure Control In Patients With Brain Tumors Hackensack, NJ 12/03/2005
Details A Phase I Trial of CC-8490 for the Treatment of Patients with Recurrent/Refractory High-Grade Gliomas Bethesda, MD 11/27/2005
Details A Pilot Study of 1H-Nuclear Magnetic Resonance Spectroscopic Imaging in Pediatric Patients with Primary and Metastatic Brain Tumors Bethesda, MD
Bethesda, MD
11/27/2005
Details A Randomized Phase II Study of Peg-Interferon Alpha-2B (Peg-Intron) Alone or in Combination with Thalidomide in Adults with Recurrent High-Grade Gliomas Los Angeles, CA
Boston, MA
Bethesda, MD
Bethesda, MD
Ann Arbor, MI
New York, NY
Pittsburgh, PA
Houston, TX
San Antonio, TX
Madison, WI
11/27/2005
Details Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors Portland, OR 11/27/2005
Details Lonafarnib and Temozolomide in Treating Patients With Recurrent Primary Supratentorial Gliomas Lanne, Switzerland 11/27/2005
Details Computer Assisted Stereotactic Navigation For Resection Of Brain Tumors In Children And Adults Hackensack, NJ 11/27/2005
Details Double sequential high dose Thiotepa with autologous stem cell rescue for patients age <60 years with recurrent malignant brain cancer. Los Angeles, CA 11/27/2005
Details Endoscopic ventriculostomy for obstructive hydrocephalus in terminal patients with hydrocephalus and brain tumours. Kelantan, Malaysia, MALAYSIA 11/27/2005
Details Feasibility of using oral Etoposide combined with escalating doses of Tamoxifen for children with recurrent gliomas Denver, CO 11/27/2005
Details Frameless Computer Guided Stereotactic Surgery For Brain Tumors New York, NY 11/27/2005
Details Functional brain Mapping Of Motor And Speech Areas For Resection Of Tumors Near Functional Areas Of The Brain Hackensack, NJ 11/27/2005
Details Genetic Therapy of meningiomas and gliomas in the Malay population in the NorthnEast coast of Malaysia Kelantan, Malaysia, MALAYSIA 11/27/2005
Details Phase I Dose Escalation Study of Autologous Antigen-Pulsed Dendritic Cell Immunotherapy for Malignant Gliomas (e.g. Glioblastoma Multiforme, Anaplastic Astrocytoma) Los Angeles, CA
Los Angeles, CA
11/27/2005
Details Phase I/II Trial of Imatinib Mesylate; (Gleevec; ST1571) in Treatment of Recurrent Oligodendroglioma and Mixed Oligoastrocytoma Jacksonville, FL
Ames, IA
Cedar Rapids, IA
Missouri Valley, IA
Sioux City, IA
Moline, IL
Peoria, IL
Urbana, IL
Wichita, KS
Lambertville, MI
Duluth, MN
Saint Louis Park, MN
Billings, MT
Bismarck, ND
Lincoln, NE
Allentown, PA
Danville, PA
Sayre, PA
Spartanburg, SC
Rapid City, SD
Sioux Falls, SD
11/27/2005
Details Pre- and Postoperative Use of ZD1839(Iressa) in Recurrent Glioblastoma, Including Translational Research Zürich , Switzerland
Los Angeles, CA
11/27/2005
Details Regulus Navigator for use with a three point pinion - frameless stereotactic surgery New York, NY 11/27/2005
Details Risk Adapted, Multimodal Therapy In Newly Diagnosed Supratentorial Malignant Glioma, Stratified To KPS. Kreischa Dresden, GERMANY 11/27/2005
Details Volumetric Stereotactic Procedures New York, NY 11/27/2005
Details Adoptive IL-2 activated LAK cell intratumoral immunotherapy implant with adjuvant radiosurgery boost and naturopathic/nutritional immune enhancement. This is for newly diagnosed patients only. Newport Beach, CA 11/26/2005
Details Gamma Knife Radiosurgery for Brain Tumors and Arteriovenous and Cavernous Malformations St.Petersburg, Fl 11/26/2005
Details Intra-arterial carboplatin for supratentorial brain tumors Fort Worth, TX 11/26/2005
Details Aggresive emergency tumour debulking and craniectomy for patients with tumours of more than 80ml and glasgow coma scale of less than 8. Kelantan, Malaysia, MALAYSIA 11/26/2005