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Trials and Noteworthy Treatments

  Treatment Location Last Updated
Details A Phase I Trial and Pharmacokinetic Study of Trabectedin (Yondelis®, ET-743) in Children and Adolescents With Relapsed or Refractory Solid Tumors Bethesda, MD 04/22/2009
Details A Phase I Trial of Enzastaurin (LY317615) in Combination With Carboplatin in Adults With Recurrent Gliomas Bethesda, MD 04/22/2009
Details A Phase I/II Trial of ZD6474 for Patients With Recurrent High-Grade and Progressive Low-Grade Gliomas Bethesda, MD 04/22/2009
Details Multiple Ascending Dose (MAD) Study of the IGF-1R Antagonist R1507 Administered as an Intravenous Infusion in Pediatric Patients With Advanced Solid Tumors. Bethesda, MD 04/22/2009
Details Phase II Trial of Tamoxifen and Bortezomib in Patients With Recurrent High-Grade Gliomas Bethesda, MD 04/22/2009
Details A Phase II Clinical Trial of the Histone Deacetylase Inhibitor Valproic Acid in Combination With Temodar and Radiation Therapy in Patients With High Grade Gliomas Bethesda, MD 04/21/2009
Details A Phase II Trial of Bevacizumab (avastin) and Irinotecan (CPT-11) for Patients With Recurrent High-Grade Gliomas Immediately Following Tumor Progression After Treatment With Bevacizumab Alone: A Companion Trial to NCI Study 06-C-0064 (Bevacizumab Alone for Recurrent Gliomas) Bethesda, MD 04/21/2009
Details A Phase II Trial of Enzastaurin in Combination With Bevacizumab in Adults With Recurrent Malignant Gliomas Bethesda, MD 04/21/2009
Details Phase II Trial of Bevacizumab (Avastin)for Patients With Recurrent High-Grade Glioma Bethesda, MD 04/21/2009
Details A Pharmacokinetic and Phase 2 Study of Sunitinib Malate in Recurrent Malignant Gliomas Toronto, Ontario, CANADA
Bethesda, MD
New York, NY
Cincinnati,, OH
Columbus, OH
04/21/2009
Details An Open Label Dose Escalation Safety Study of Convection-Enhanced Delivery of IL13-PE38QQR in Patients With Progressive Pediatric Diffuse Infiltrating Brainstem Glioma and Supratentorial High-Grade Glioma Bethesda, MD 04/15/2009
Details Phase I Trial of Conditionally Replication-Competent Adenovirus (Delta-24-RGD4C) for recurrent malignant glioma Houston, TX 04/14/2009
Details A Phase I Trial of Nanoliposomal CPT-11 (NL CPT-11) in Patients With Recurrent High-Grade Gliomas San Francisco, CA 04/06/2009
Details Phase I Pilot Study of HLA-A2-Restricted Synthetic Glioma Antigen Peptide Vaccine and Poly ICLC Vaccine in Young Patients With Newly Diagnosed Malignant or Intrinsic Brain Stem Glioma, Incompletely Resected Non-Brainstem High-Grade Glioma, or Recurrent Unresectable Low-Grade Glioma Pittsburgh, PA 03/16/2009
Details Quality of Life in Patients with Brain Tumors, Skull Base Tumors & Pituitary Adenomas Undergoing Surgical Resection Santa Monica, CA 11/29/2008
Details Bevacizumab (Avastin) and Irinotecan (CPT-11) in Treating Young Patients With Recurrent, Progressive, or Refractory Glioma, Medulloblastoma, Ependymoma, or Low Grade Glioma San Francisco, CA
Washington, DC
Chicago, IL
Boston, MA
Bethesda, MD
Durham, NC
Philadelphia, PA
Pittsburgh, PA
Memphis, TN
Seattle, WA
11/08/2008
Details A Phase II Trial of Thalidomide in combination with Temozolomide or CPT-11 in patients with recurrent anaplastic gliomas or glioblastoma multiforme Houston, TX 10/27/2008
Details Phase I Trial of Aflibercept (VEGF Trap)with Radiation Therapy and Concomitant and Adjuvant Temozolomide in Patients With Malignant Gliomas Los Angeles, CA
San Francisco, CA
Boston, MA
Durham, NC
New York, NY
Pittsburgh, PA
Houston, TX
San Antonio, TX
Madison, WI
10/27/2008
Details BIBW 2992 with or without daily temozolomide in the treatment of patients with recurrent malignant glioma Charlottesville, VA 10/20/2008
Details A Phase 1, Open-Label, Dose Escalation Study of ANG1005 in Patients With Malignant Glioma Boston, MA
New York, NY
Houston, TX
Charlottesville, VA
10/09/2008
Details Erlotinib and Temozolomide With Radiation Therapy in Treating Patients With Glioblastoma Multiforme or Other Brain Tumors Charlottesville, VA 09/30/2008
Details Gliogene: An International Brain Tumor Study Houston, TX 07/24/2008
Details Phase I/II Trial of Irinotecan plus Lenalidomide in Adult Patients with Recurrent Glioblastoma Multiforme Houston, TX 05/28/2008
Details Phase 1, Open-Label, Dose Escalation Study of ANG1005 in Patients with Malignant Glioma Houston, TX 05/28/2008
Details Phase I/II Adaptive Randomized Trial of Vorinostat, Isotretinoin and Carboplatin in Adults With Recurrent Glioblastoma Multiforme Houston , TX 04/27/2008
Details Phase I / II Adaptive Randomized Trial of Vorinostat, Isotretinoin and Carboplatin in Adults with Recurrent Glioblastoma Multiforme Houston, TX 04/15/2008
Details Phase I/II Study of OSI-774 (Erlotinib) and CCI-779 (Temsirolimus) in Patients with Recurrent Malignant Glioma Houston, TX 04/15/2008
Details A Phase I Study of Vorinostat [Suberoylanilide Hydroxamic Acid (SAHA)] in Combination with Temozolomide in Patients with Malignant Gliomas Los Angeles, CA
Boston, MA
Durham, NC
New York, NY
Houston, TX
04/15/2008
Details Combination of 6-Thioguanine, Capecitabine, Celecoxib and Temozolomide or CCNU for Recurrent Anaplastic Glioma Houston, TX 04/15/2008
Details A Phase l Trial of Surgical Resection With Gliadel Wafer Placement Followed by Vaccination With Dendritic Cells Pulsed With Tumor Lysate for Patients With Malignant Glioma Los Angeles, CA 03/02/2008
Details Phase I Dose Escalation Study of Autologous Tumor Lysate-Pulsed Dendritic Cell Immunotherapy for Malignant Gliomas in Pediatric Patients Los Angeles, CA 03/02/2008
Details Phase I Study of Glioma-Associated Antigen (GAA) Peptide-Pulsed Dendritic Cell Vaccination in Malignant Glioma Patients Los Angeles, CA 03/02/2008
Details Phase I Study of Immunization With Autologous Tumor Lysate-Pulsed Dendritic Cells in Patients With Malignant Gliomas (Vaccine Therapy in Treating Patients With Malignant Glioma) Los Angeles, CA 03/02/2008
Details Phase I/II Study of GP96 Heat Shock Protein-Peptide Complex Vaccine in Patients With Recurrent or Progressive High-Grade Glioma San Francisco, CA 03/02/2008
Details Phase ll Trial of Tumor Lysate-Pulsed Dendritic Cell Immunotherapy for Patients With Atypical or Malignant, Primary or Metastatic Brain Tumors of the Central Nervous System Los Angeles, CA 03/02/2008
Details A phase I/II Evaluation of Vaccination with Type-1 Dendritic Cells Pulsed With Multiple Peptides In the Treatment of HLA-A2 Positive Patients With Recurrent Malignant Gliomas Pittsburgh, PA 03/02/2008
Details NTI 0501: An Open-Labeled, Extended-Use of Human Corticotropin-Releasing Factor (hCRF) (Xerecept) Intended for Patients Who Participate in Dexamethasone-Sparing Studies NTI 0302 or NTI 0303 Kingston, Ontario, CANADA
Edmonton, Alberta, CANADA
Moncton, New Brunswick, CANADA
Ottawa, Ontario, CANADA
Toronto, Ontario, CANADA
Winnipeg, Manitoba, CANADA
Phoenix, AZ
La Jolla, CA
Palo Alto, CA
Sacramento, CA
Aurora, CO
Englewood, CO
Jacksonville, FL
Orlando, FL
Chicago, IL
Evanston, IL
Boston, MA
Detroit, MI
Winston-Salem, NC
Edison, NJ
Buffalo, NY
Columbus, OH
Columbus, OH
Portland, OR
Memphis, TN
Nashville, TN
Seattle, WA
Madison, WI
03/01/2008
Details Gliogene: Brain Tumor Linkage Study San Francisco, CA
Tampa, FL
Boston, MA
New York, NY
Houston, Tx
01/17/2008
Details Phase II Study Of 7 Days On/7 Days Off Temozolomide In Patients With High-Grade Glioma San Francisco, CA 01/17/2008
Details NABTC 04-03: A Phase I Study of Vorinostat (Suberolyanilide Hydroxamic Acid [SAHA]) in Combination with Temozolomide in Patients with Malignant Gliomas San Francisco, CA 10/03/2007
Details Phase I/II trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine For Patients With Recurrent High Grade Glioma San Francisco, CA 10/03/2007
Details NABTC 04-02: Erlotinib and Temsirolimus in Treating Patients With Recurrent Malignant Glioma Los Angeles, CA
Boston, MA
Durham, NC
New York, NY
Pittsburgh, PA
Houston, TX
San Antonio, TX
Madison, WI
10/03/2007
Details A Pharmacokinetic and Pharmacogenomic Study of Patients With High-Grade Gliomas Receiving Daily Radiation Therapy and Temozolomide Duarte, CA
Baltimore, MD
08/31/2007
Details A Phase IIa Safety and Light Dose-Escalation Study in Patients With Primary or Recurrent/High-Grade Glioma (Defined for the Purposes of the Protocol as Anaplastic Astrocytoma [AA] or Glioblastoma Multiforme [GBM]) Using the Litx™ System to Confirm the Zone of Tumor Destruction During the Intraoperative Treatment of Glioma , Serbia 08/26/2007
Details Phase I Study of Enzastaurin and Temozolomide in Patients With Gliomas Glasgow, Scotland, UK 08/26/2007
Details Phase I/II Study of Fractionated CyberKnife Stereotactic Radiosurgery for High Grade Gliomas in Elderly Patients With Poor Performance Status Boston, MA 08/26/2007
Details The Effect of Radiotherapy and Temozolomide on the Tumor Vasculature and Stem Cells in Human High-Grade Astrocytomas Bergen, Norway 08/26/2007
Details A Phase 1/11 Study of Topotecan by Intracerebral Clysis for the Treatment of Recurrent Primary Malignant Brain Tumors NEW YORK CITY, NY 08/20/2007
Details A Phase I Study of Imatinib Mesylate (Gleevec) in Combination With Temozolomide (Temodar) in Patients With Malignant Glioma Durham, NC 08/20/2007
Details A Phase II Pilot Trial of Radiation Therapy With Concurrent and Adjuvant Temozolomide, Tamoxifen and Carboplatin (T2C) in the Treatment of Patients With Primary Central Nervous System Malignant Gliomas Vista, CA 08/20/2007
Details A Phase II Safety Study of Bevacizumab in Patients With Multiple Recurrent or Progressive Malignant Gliomas Chicago, IL 08/20/2007
Details Determination of the In-Tumor-Concentration of Imatinib Mesylate (Gleevec) in Malignant Glioma After Oral Administration Baltimore, MD 08/20/2007
Details Phase II Study of Intrathecal I-3F8 in Patients With GD2-Expressing Central Nervous System and Leptomeningeal Neoplasms New York, NY 08/20/2007
Details A Phase II Trial With Bevacizumab (Avastin) and Irinotecan (CPT-11) for Patients With Primary Brain Tumors and Progression After Standard Therapy Copenhagen, Denmark 08/18/2007
Details Changes in Semen or Sperm Caused by Temozolomide in Patients With Newly Diagnosed, Progressive, or Recurrent Primary Malignant Brain Tumors Winston-Salem, NC 08/18/2007
Details Combination of 6-Thioguanine, Capecitabine, Celecoxib and Temozolomide or CCNU for Recurrent Anaplastic Glioma and Glioblastoma Multiforme Houston, TX 08/18/2007
Details Identification of Hypermethylated Serum Tumor DNA in High Grade Glioma Patients and Correlation with Magnetic Resonance Imaging Findings Cleveland, OH 08/18/2007
Details Phase I study of Gefitinib plus Rapamycin for patients with recurrent malignant glioma. Los Angeles, CA
Durham, NC
08/18/2007
Details Phase II Trial of Tumor Lysate-Pulsed Dendritic Cell Immunotherapy for Patients with Atypical or Malignant, Primary or Metastatic Brain Tumors of the Central Nervous System Los Angeles, CA 08/18/2007
Details The use of the Gliasite radiation therapy system for malignant gliomas Philadelphi, PA 08/18/2007
Details A Phase II Trial of Continuous Low-Dose Temozolomide for Patients With Recurrent Malignant Glioma New York, NY 08/18/2007
Details Brain Mapping for Brain Tumors Boston, MA 08/18/2007
Details Functional image guided removal of brain tumors Manhasset, NY 08/18/2007
Details Gliadel and Dendritic Cell Vaccine for Malignant Glioma Los Angeles, CA 08/18/2007
Details Improving Quality Of Life For Brain Tumor Patients Los Angeles, CA 08/18/2007
Details Phase 1 Trial Gamma Knife For Primary Brain Tumors - Gliomas. Birmingham, AL 08/18/2007
Details Phase I Study Of Pioglitazone And Isotretinoin In Patients With Recurrent Or Progressive Malignant Gliomas Los Angeles, CA 08/18/2007
Details Pilot Study of Bevacizamab in Patients with Recurrent or Progressive Primary Brain Tumors Los Angeles, CA 08/18/2007
Details A Phase II Study of Temozolomide and O6-Benzylguanine (O6-BG) in Patients With Temozolomide-Resistant Anaplastic Glioma Los Angeles, CA 08/04/2007
Details Poly-ICLC in Treating Patients With Recurrent or Progressive Anaplastic Glioma Los Angeles, CA
Boston, MA
New York, NY
Pittsburgh, PA
Houston, TX
Madison, WI
08/04/2007
Details A Pilot Study of Temozolomide and 06Benzylguanine for Treatment of Newly Diagnosed High Grade Glioma, Using Autologous Peripheral Blood Stem Cells Genetically Modified for Chemoprotection Cincinnati , OH 05/01/2007
Details Evaluation of a Stress Reduction Program in Patients With Malignant Brain Tumors and Their Family Caregivers Cleveland, OH 05/01/2007
Details Phase I and II, Open-Label, Multi-Center Trials of Pazopanib in Combination With Lapatinib in Adult Patients With Relapsed Malignant Glioma Tampa, FL
Atlanta, GA
Chicago, IL
Boston, MA
Detroit, MI
Durham, NC
Cleveland, OH
05/01/2007
Details Phase I Evaluation of Sodium Stibogluconate in Combination With Interferon a-2b for Solid Tumors, Lymphoma or Myeloma Cleveland, OH 05/01/2007
Details Phase I/II Study of Intravenous Infusion of Tetra-o-Methyl Nordihydroguaiaretic Acid (EM-1421) in Subjects With Recurrent High Grade Glioma Birmingham, AL
Tampa, FL
Atlanta, GA
Boston, MA
Baltimore, MD
Detroit, MI
Winston-Salem, NC
Cleveland, OH
Philadelphia, PA
05/01/2007
Details Sorafenib in Treating Patients With Recurrent or Progressive Malignant Glioma Detroit, MI 05/01/2007
Details A Phase II Study of a Temozolomide-Based Chemoradiotherapy Regimen for High-Risk Low-Grade Gliomas Phoenix, AZ
New Haven, CT
Lewes, DE
Fort Lauderdale, FL
Jacksonville, FL
Jacksonville, FL
Miami, FL
Columbus, GA
Dubuque, IA
Detroit, MI
Kalamazoo, MI
Lambertville, MI
Rochester, MN
Rochester, MN
Saint Louis Park, MN
Springfield, MO
Omaha, NB
Goldsboro, NC
Lebanon, NH
Long Branch, NJ
Mount Holly, NJ
Albuquerque, NM
Buffalo, NY
Utica, NY
, OH
Akron, OH
Cleveland, OH
Tulsa, OK
Portland, OR
Philadelphia, PA
Philadelphia, PA
Wynnewood, PA
Greenville, SC
Kingsport, TN
Salt Lake City, UT
Madison, WI
05/01/2007
Details Phase II Randomized Study of Intra-Arterial Carboplatin, Cyclophosphamide, and Etoposide or Etoposide Phosphate With or Without Delayed High-Dose Sodium Thiosulfate in Patients With High-Grade Glioma Cleveland, OH
Columbus, OH
Portland, OR
05/01/2007
Details Phase III Randomized Study of Radiotherapy Combined With Temozolomide Versus Carmustine in Patients With Anaplastic Astrocytoma or Mixed Gliomas Jacksonville, FL
Boston, MA
Rochester, MN
Cleveland, OH
05/01/2007
Details Phase II Pilot Study of Adjuvant Radiotherapy and Temozolomide Followed By Temozolomide and Lomustine in Pediatric Patients With Newly Diagnosed High-Grade Gliomas Birmingham, AL
Phoenix, AZ
Phoenix, AZ
Downey, CA
Long Beach, CA
Los Angeles, CA
Sacramento, CA
Denver, CO
Jacksonville, FL
St. Petersburg, FL
West Palm Beach, FL
Atlanta, GA
Augusta, GA
Honolulu, HI
Iowa City, IA
Chicago, IL
Park Ridge, IL
New Orleans, LA
Boston, MA
Baltimore, MD
Scarborough, ME
Grand Rapids, MI
Kansas City, MO
Saint Louis, MO
Saint Louis, MO
Omaha, NE
Hackensack, NJ
Summit, NJ
Las Vegas, NV
Brooklyn, NY
New Hyde Park, NY
New York, NY
Rochester, NY
Valhalla, NY
Cleveland, OH
Cleveland, OH
Dayton, OH
Pittsburgh, PA
Knoxville, TN
Memphis, TN
Dallas, TX
Fort Worth, TX
Houston, TX
Lubbock, TX
San Antonio, TX
Falls Church, VA
Roanoke, VA
Burlington, VT
Milwaukee, WI
Huntington, WV
04/29/2007
Details Combination Therapy With Thalidomide and CPT-11 in Patients With Recurrent Anaplastic Gliomas or Glioblastoma Multiforme Houston , TX 04/15/2007
Details RTA 744 in Treating Patients With Recurrent or Refractory Anaplastic Astrocytoma, Anaplastic Oligodendroglioma, Anaplastic Mixed Oligoastrocytoma, Glioblastoma Multiforme, or Gliosarcoma Los Angeles, CA
Dallas, TX
11/21/2006
Details Phase I/II Trial of Oral Erlotinib (Tarceva, OSI-774) for Treatment of Relapsed/Refractory Glioblastoma Multiforme and Anaplastic Astrocytoma New York, NY 10/12/2006
Details TREATMENT OF NEWLY DIAGNOSED, HIGH-GRADE, MALIGNANT GLIOMA WITH POLIFEPROSAN 20 CONTAINING CARMUSTINE IMPLANT (GLIADEL® WAFER) USING MR SPECTROSCOPY DATA AS A PRIMARY INDICATOR OF THERAPEUTIC RESPONSE New York, NY 10/12/2006
Details Comprehensive Genetic Analysis Of Brain Tumors In Children. (A Non-Therapeutic Study) ,
, Canada
, Canada
, Canada
, Canada
, Canada
, Canada
, Switzerland
, Switzerland
Auckland, New Zealand
Perth, Western Australia, 6001, Australia
Randwick, New South Wales, 2031, Australia
Phoenix, AZ
Downey, CA
Loma Linda, CA
Los Angeles, CA
Los Angeles, CA
Los Angeles, CA
Madera, CA
Oakland, CA
Orange, CA
Orange, CA
Sacramento, CA
San Francisco, CA
Santa Barbara , CA
Travis Air Force Base, CA
Denver, CO
Farmington, CT
Washington, DC
Washington, DC
Wilmington, DE
Atlanta, GA
Macon, GA
Savannah, GA
Des Moines, IA
Chicago, IL
Chicago, IL
Park Ridge, IL
Indianapolis, IN
Springfield, MA
Baltimore, MD
Ann Arbor, MI
Detroit, MI
Grand Rapids, MI
Kalamazoo, MI
Royal Oak, MI
Royal Oak, MI
Minneapolis, MN
Rochester, MN
Kansas City, MO
Chapel Hill, NC
Charlotte, NC
Winston-Salem, NC
Fargo, ND
Omaha, NE
Omaha, NE
Brunswick, NJ
Newark, NJ
Paterson, NJ
Summit, NJ
Las Vegas, NV
Albany, NY
Bronx, NY
Brooklyn, NY
Brooklyn, NY
Brooklyn, NY
Brooklyn, NY
New Hyde Park, NY
New York, NY
Stony Brook, NY
Syracuse, NY
Akron, OH
Cincinnati, OH
Cleveland, OH
Columbus, OH
Dayton, OH
Toledo, OH
Portland, OR
Danville, PA
Philadelphia, PA
Pittsburgh, PA
Sioux Falls, SD
Johnson City, TN
Knoxville, TN
Nashville, TN
Amarillo, TX
Austin, TX
Dallas, TX
Houston, TX
Lubbock, TX
San Antonio, TX
San Antonio, TX
Temple, TX
Norfolk, VA
Seattle, WA
Seattle, WA
Spokane, WA
Tacoma, WA
Green Bay, WI
Green Bay, WI
Green Bay, WI
La Crosse, WI
Madison, WI
Marshfield, WI
Marshfield, WI
Huntington, WV
10/12/2006
Details Erlotinib and Temozolomide With Radiation Therapy in Treating Patients With Glioblastoma Multiforme or Other Brain Tumors Birmingham, AL
Scottsdale/Phoenix, AZ
Jacksonville, FL
Cedar Rapids, IA
Des Moines, IA
Missouri Valley, IA
Sioux City, IA
Moline, IL
Peoria, IL
Urbana, IL
Wichita, KS
Rochester, MN
Saint Cloud, MN
Bismarck, ND
Fargo, ND
Lincoln, NE
Allentown, PA
06/26/2006
Details Phase I/II Study of High Dose Irinotecan (Camptosar, CPT-11) in Patients With Recurrent Unresectable Malignant Glioma on Steroids/Anti-Epileptics Louisville, KY 05/29/2006
Details Pilot Randomized Study of Modafinil for Treatment of Fatigue and Neurobehavioral Dysfunction in Patients With Primary Brain Tumors Los Angeles, CA 05/29/2006
Details A Phase II Study of Radiation With Concomitant and Then Sequential Temozolomide in Patients With Newly Diagnosed Supratentorial Malignant Glioma Who Have Undergone Surgery With Gliadel Wafer Insertion Louisville, KY 05/27/2006
Details Genetic Epidemiology of Adult-Onset Glioma Louisville, KY 05/27/2006
Details Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors Washington, DC
Chicago, IL
Boston, MA
Bethesda, MD
Philadelphia, PA
Pittsburgh, PA
Memphis, TN
Houston, TX
Seattle, WA
05/27/2006
Details Comparative 2-D Tumor Analysis in Familial Gliomas Edmonton, Alberta, Canada 05/04/2006
Details PEG-Interferon alfa-2b With or Without Thalidomide in Treating Patients With Recurrent High-Grade Gliomas Los Angeles, CA
Boston, MA
Ann Arbor, MI
New York, NY
Pittsburgh, PA
Houston, TX
San Antonio, TX
Madison, WI
05/04/2006
Details A Phase I Trial Using Combination Irinotecan (CPT-11) and Thalidomide for Recurrent CNS Tumors Albuquerque, NM 05/02/2006
Details A Pilot Study of Dronabinol for the treatment of nausea,vomiting and appetite loss in Adult Patients With Primary Gliomas Durham, NC 05/01/2006
Details Phase II Study of Pemetrexed Disodium (Alimta) in Patients With Recurrent Malignant Gliomas, Primary CNS Lymphoma, or Brain Metastases Chicago, IL 05/01/2006
Details Pilot Study of the Safety and Accuracy of Fluorothymidine F 18 Positron Emission Tomography in Detecting Recurrent Disease in Patients With Gliomas Seattle, WA 05/01/2006
Details "Head Start" chemotherapy protocol for children less than 10 years old with newly diagnosed high grade primary brain tumors with intent to eliminate irradiation and abbreviate total duration of treatment to 6 months with resultant improved cure rate and quality of survival. Oakland, CA 05/01/2006
Details Headstart II A Phase II study of two alternative intensive induction chemotherapy followed by consolidation with myeloablative chemotherapy and autologous stem cell rescue with or without subsequent radiation therapy for children less than 10 yrs of age newly diagnosed with malignant brain tumors Oakland, CA 05/01/2006
Details Phase II Study of O6-Benzylguanine and Temozolomide (Temodar) in Pediatric Patients With Recurrent or Progressive High-Grade Gliomas or Brain Stem Tumors Chicago, IL
Bethesda, MD
Durham, NC
Durham, NC
Lincoln, NE
Philadelphia, PA
Memphis, TN
Houston, TX
Seattle, WA
05/01/2006
Details Phase II trial of Temodar ® plus O6-Benzylguanine in the treatment of patients with Temodar® -resistant malignant glioma. Durham, NC 12/03/2005
Details Pharmacological intervention for learning impaired children surviving treatment for cancer. Durham, NC 12/03/2005
Details Gamma Knife Radiosurgery Smithtown, NY 12/03/2005
Details Gamma Knife Radiosurgery for Brain Tumors La Jolla, CA 12/03/2005
Details Phase I trial of Temodar plus O6-Benzylguanine plus Irinotecan (CPT-11) in the treatment of patients with recurrent/progressive Cerebral anaplastic gliomas. Durham, NC 12/03/2005
Details Phase I trial of Temozolomide (Temodar) and O6-Benzylguanine (o6-bg)in pediatric patients with recurrent brain tumors. Durham, NC 12/03/2005
Details The use of the Gliasite radiation therapy system for malignant gliomas Mobile , AL 12/03/2005
Details A Phase I dose escalation trial of Temodar that will attempt to determine the maximum tolerated dose of Temodar (Temozolomide) when given by prolonged oral exposure to children with recurrent or progressive brain tumors. New York, NY 12/03/2005
Details Fractionated Stereotactic Radiosurgery plus Topotecan radiation sensitizer in the treatment of recurrent malignant astrocytoma or as consolidation after external beam radiotherapy. New York, NY 12/03/2005
Details Gamma Knife Radiosurgery Edison, NJ 12/03/2005
Details Gamma knife stereotactic radiosurgery for benign and malignant brain tumors and brain metastases. Rockville Centre, NY 12/03/2005
Details Gliadel Wafer Implantation For Malignant Gliomas Of The Brain Smithtown, NY 12/03/2005
Details Phase I Dose Escalation Study of Gliadel in Adults with Recurrent Malignant Gliomas Baltimore, MD
Detroit, MI
Winston-Salem, NC
Philadelphia, PA
12/03/2005
Details Phase I/II Study of Multiple Light Fiber Interstitial Photodynamic Therapy for Primary and Metastatic Supratentorial Brain Tumors Hershey, PA 12/03/2005
Details Quality of Life Studies (There are 19 seperate studies listed here) Durham, NC 12/03/2005
Details Use of Epilepsy Monitoring And Electrocorticography For Seizure Control In Patients With Brain Tumors Hackensack, NJ 12/03/2005
Details A Pilot Study of 1H-Nuclear Magnetic Resonance Spectroscopic Imaging in Pediatric Patients with Primary and Metastatic Brain Tumors Bethesda, MD 11/27/2005
Details A Randomized Phase II Study of Peg-Interferon Alpha-2B (Peg-Intron) Alone or in Combination with Thalidomide in Adults with Recurrent High-Grade Gliomas Los Angeles, CA
Boston, MA
Ann Arbor, MI
New York, NY
Pittsburgh, PA
Houston, TX
San Antonio, TX
Madison, WI
11/27/2005
Details Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors Portland, OR 11/27/2005
Details Lonafarnib and Temozolomide in Treating Patients With Recurrent Primary Supratentorial Gliomas Lanne, Switzerland 11/27/2005
Details Melphalan and Mannitol in Treating Patients With Central Nervous System Tumors Portland, OR 11/27/2005
Details Temozolomide in Treating Patients With Progressive Low-Grade Glioma San Francisco, CA
Durham, NC
Philadelphia, PA
11/27/2005
Details A Phase I, Molecular Biology, and Phase II Study of Lapatinib (GW572016) in Pediatric Patients with Recurrent or Refractory Medulloblastoma, Malignant Glioma or Ependymoma Washington, DC
Chicago, IL
Boston, MA
Durham, NC
Philadelphia, PA
Pittsburgh, PA
Memphis, TN
Memphis, TN
Houston, TX
Seattle, WA
11/27/2005
Details Arsenic Trioxide and Radiation Therapy in Treating Young Patients With Newly Diagnosed Gliomas (Brainstem glioma, glioblastoma multiforme, gliosarcoma, anaplastic astrocytoma) Baltimore, MD 11/27/2005
Details Computer Assisted Stereotactic Navigation For Resection Of Brain Tumors In Children And Adults Hackensack, NJ 11/27/2005
Details Double sequential high dose Thiotepa with autologous stem cell rescue for patients age <60 years with recurrent malignant brain cancer. Los Angeles, CA 11/27/2005
Details Endoscopic ventriculostomy for obstructive hydrocephalus in terminal patients with hydrocephalus and brain tumours. Kelantan, Malaysia, MALAYSIA 11/27/2005
Details Feasibility of using oral Etoposide combined with escalating doses of Tamoxifen for children with recurrent gliomas Denver, CO 11/27/2005
Details Frameless Computer Guided Stereotactic Surgery For Brain Tumors New York, NY 11/27/2005
Details Functional brain Mapping Of Motor And Speech Areas For Resection Of Tumors Near Functional Areas Of The Brain Hackensack, NJ 11/27/2005
Details Genetic Therapy of meningiomas and gliomas in the Malay population in the NorthnEast coast of Malaysia Kelantan, Malaysia, MALAYSIA 11/27/2005
Details Longitudinal Neuropsychologic Evaluation And Strategic Educational Interventions. Houston, TX 11/27/2005
Details Multiple Courses of High Dose Chemotherapy With Peripheral Stem Cell Support in Relapsed, Refractory or Progressive Glial Tumors and in Children With Glioblastoma or Incompletely Resected Anaplastic Astrocytoma at the Time of Diagnosis. Hackensack, NJ 11/27/2005
Details Phase 2 Trial of Multi-Agent High Dose Chemotherapy Followed By Stem Cell Rescue For High Grade Gliomas in Adults. Hackensack, NJ 11/27/2005
Details Phase 2 Trial of Stereotactic Radiosurgery For Recurrent Pediatric Brain Tumors Hackensack, NJ 11/27/2005
Details Phase I Dose Escalation Study of Autologous Antigen-Pulsed Dendritic Cell Immunotherapy for Malignant Gliomas (e.g. Glioblastoma Multiforme, Anaplastic Astrocytoma) Los Angeles, CA
Los Angeles, CA
11/27/2005
Details Pre- and Postoperative Use of ZD1839(Iressa) in Recurrent Glioblastoma, Including Translational Research Zürich , Switzerland
Los Angeles, CA
11/27/2005
Details Regulus Navigator for use with a three point pinion - frameless stereotactic surgery New York, NY 11/27/2005
Details Rehabilitation For Brain Tumor Patients. Houston, TX 11/27/2005
Details Risk Adapted, Multimodal Therapy In Newly Diagnosed Supratentorial Malignant Glioma, Stratified To KPS. Kreischa Dresden, GERMANY 11/27/2005
Details Volumetric Stereotactic Procedures New York, NY 11/27/2005
Details Adoptive IL-2 activated LAK cell intratumoral immunotherapy implant with adjuvant radiosurgery boost and naturopathic/nutritional immune enhancement. This is for newly diagnosed patients only. Newport Beach, CA 11/26/2005
Details Gamma Knife Radiosurgery for Brain Tumors and Arteriovenous and Cavernous Malformations St.Petersburg, Fl 11/26/2005
Details Intra-arterial carboplatin for supratentorial brain tumors Fort Worth, TX 11/26/2005
Details Use of interferon for the treatment of gliomas of the brain and spine. Kelantan, Malaysia, MALAYSIA 11/26/2005
Details Aggresive emergency tumour debulking and craniectomy for patients with tumours of more than 80ml and glasgow coma scale of less than 8. Kelantan, Malaysia, MALAYSIA 11/26/2005
Details Chemotherapy,radiotherapy and immunotherapy for brain tumors. Guangzhou, CHINA (PR) 11/26/2005
Details Computer assisted minimally invasive image guided surgery for improved resection of malignant brain tumors and frameless stereotactic brain biopsies For Deep Brain Tumors. Smithtown, NY 11/26/2005
Details Concurrent Temozolomide and Radiotherapy Followed By Dose Dense Versus Metronomic Temozolomide and Maintenance Cis-Retinoic Acid For Patients With Newly Diagnosed Glioblastoma And Other Malignant Gliomas New York, NY 11/26/2005
Details Headstart II A Phase II study of two alternative intensive induction chemotherapy followed by consolidation with myeloablative chemotherapy and autologous stem cell rescue with or without subsequent radiation therapy for children less than 10 yrs of age newly diagnosed with malignant brain tumors New York, NY 11/26/2005
Details Intraoperative navigation in neurosurgical patients Boston, MA 11/26/2005
Details Phase I study of Photodynamic Therapy with porfimer sodium for refractory brain tumors Milwaukee, WI 11/26/2005
Details Phase I/II Trial of Temodar and Escalating Doses of Oral VP-16 for Patients with Recurrent Malignant Glioma Rochester, NY 11/26/2005
Details PS-341 With Oral Temozolomide in Patients With Advanced Refractory Solid Tumors or Melanoma Nashville, TN 11/26/2005
Details Reliable Imaging Diagnosis of Recurrent Brain Tumor Winston-Salem, NC 11/26/2005
Details Frameless Computer Assisted Stereotactic Surgery for Resection of Brain Tumors in Adults and Children Rockford, IL 11/25/2005
Details Frameless Computer Guided Stereotactic Sugery for Resection of Brain Tumors in Adults and Children Rockford, IL 11/25/2005
Details Brain tumor surgery using a compact intraoperative MRI Manhasset, NY 11/25/2005
Details Long-term survivors of high grade gliomas. Salt Lake City, UT 11/24/2005
Details A trial of Dalteparin low molecular weight heparin for primary prophylaxis of venous thromboembolism in brain tumor patients. Salt Lake City, UT 11/24/2005
Details Use of Hight Dose Tamoxifen For Patients Who Refuse Surgery For meningiomas and Gliomas. Kelantan, Malaysia, MALAYSIA 11/24/2005
Details Gene Therapy Of Malignant Gliomas: A Pilot Study of Vaccination With Autologous Glioma-Lysate And Dendritic Cells Admixed With IL-4 Transduced Fibroblasts To Elicit An Immune Response. Pittsburgh, PA 11/21/2005
Details Oral ST 1481 in adults with Malignant Glioma: a Phase I-II Clinical Trial Providence, RI 11/21/2005
Details Fractionated Stretactic Radiotherapy Boost with weekly Paclitaxel in malignant gliomas. Brooklyn, NY 11/20/2005
Details Phase I Brachytherapy Dose Escalating Study Using the Proxima Therapeutics, Inc. GliaSIte RTS in Patients with Recurrrent Malignant Gliomas Winston-Salem, NC 11/20/2005
Details Phase I/II trial of Temodar and escalating doses of Oral VP-16 for patients with recurrent malignant gliomas. Durham, NC 11/20/2005
Details Phase II treatment with Irinotecan (CPT-11) plus Celebrex® of adults with primary malignant glioma. Durham, NC 11/20/2005
Details Streotactic Radiosurgery for brain lesions Brooklyn, NY 11/20/2005
Details "Head Start" chemotherapy protocol for children less than 10 years old with newly diagnosed high grade primary brain tumors with intent to eliminate irradiation and abbreviate total duration of treatment to 6 months with resultant improved cure rate and quality of survival. Los Angeles, CA 11/20/2005
Details Intraoperative MRI for brain tumors Boston, MA 11/20/2005
Details Stereotactic Radiosurgery for High Grade Gliomas, for Lesions <4cm AND >4cm. Brachytherapy for Lesions >4cm Hackensack, NJ 11/20/2005
Details Activation of A Pilot Comparison Bioavailability Study of Oral and Intravenously Administered Temozolomide (Temodar) in patients with primary CNS malignancies. Durham, NC 11/13/2005
Details Phase I/II trial of ZD1839 (Iressa) in pediatric patients newly diagnosed with brain stem tumors or incompletely resected supratentorial malignant gliomas. Durham, NC 11/13/2005
Details Phase II study of VNP40101M for the treatment of adults with newly diagnosed or recurrent malignant glioma. Durham, NC 11/13/2005
Details Phase I treatment with Irinotecan (CPT-11) plus Temozolomide (Temodar) of children with primary recurrent malignant brain tumors. Durham, NC 11/13/2005
Details Phase I trial of Oral Topotecan plus Temodar in the treatment of patients with recurrent/progressive malignant gliomas. Durham, NC 11/13/2005
Details Phase II trial of Gleevec plus hydroxyurea in the treatment of patients with malignant glioma Durham, NC 11/13/2005
Details Pilot study of genetic and environmental Risk and outcome for newly diagnosed brain tumor patients and controls. Durham, NC 11/13/2005
Details Pilot trial of Innohep (Tinzaparin) Low Molecular Weight Heparin for primary prophylaxis of venous thromboembolism in brain tumor patients. Durham, NC 11/13/2005
Details Temozolomide Compared to Procarbazine, Lomustine, and Vincristine in Treating Patients With Recurrent Malignant Glioma , England 11/13/2005
Details Antineoplaston Therapy in Treating Children With Brain Tumors Houston, TX 11/11/2005
Details Carboplatin, Vincristine, and Temozolomide in Treating Children With Progressive and/or Symptomatic Low-Grade Glioma Washington, DC
Chicago, IL
Baltimore, MD
Memphis, TN
Dallas, TX
Houston, TX
11/11/2005
Details Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Central Nervous System Cancer New York, NY 11/11/2005
Details Thalidomide and Temozolomide in Treating Young Patients With Relapsed or Progressive Brain Tumors or Recurrent Neuroblastoma Boston, MA 11/11/2005
Details Thiotepa Followed by Peripheral Stem Cell or Bone Marrow Transplantation in Treating Patients With Malignant Glioma (Glioblastoma multiforme, Gliosarcoma, Anaplastic astrocytoma, PNET, Oligodendroglioma) Paterson, NJ
New York, NY
11/11/2005
Details TP-38 Toxin in Treating Young Patients With Recurrent or Progressive Supratentorial High-Grade Glioma(or Glioblastoma multiforme) Washington, DC
Boston, MA
Memphis, TN
11/11/2005
Details VNP40101M in Treating Young Patients With Recurrent, Progressive, or Refractory Primary Brain Tumors Washington, DC
Chicago, IL
Boston, MA
Durham, NC
Philadelphia, PA
Pittsburgh, PA
Memphis, TN
Houston, TX
Seattle, WA
11/11/2005
Details A Phase I Gliadel and Escalating Doses of Intravenous O6-Benzylguanine Trial in Patients with Recurrent Malignant Glioma Baltimore, MD 11/09/2005
Details Phase I, Gliadel® & Escalating Doses of Intravenous O6-Benzylguanine in People with Recurrent Malignant Glioma Winston-Salem, NC 11/09/2005
Details Boron Neutron Capture Therapy (BNCT) to Treat Anaplastic Astrocytoma or Glioblastoma That Has Progressed Following Radiotherapy Helsinki, Finland 11/06/2005
Details Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment , Puerto Rico
Fort Myers, FL
Gainesville, FL
Jacksonville, FL
Pensacola, FL
St. Petersburg, FL
Tampa, FL
West Palm Beach, FL
Augusta, GA
Indianapolis, IN
Grand Rapids, MI
Syracuse, NY
Akron, OH
San Antonio, TX
San Antonio, TX
Temple, TX
Richmond, VA
Green Bay, WI
11/06/2005
Details Phase I study of Cilengitide in children with refractory brain tumors. Durham, NC 11/06/2005
Details SWOG (RTOG) 98-13 randomized trial of RT + Temozolomide vs RT + BCNU, versus RT+ Tem + BCNU Mobile , AL 11/06/2005
Details Erlotinib and Radiation Therapy in Treating Young Patients With Newly Diagnosed Glioma Memphis, TN 11/06/2005
Details Radiosurgery with the Varian Trilogy system for benign or malignant brain tumors Mobile , AL 11/06/2005


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Frequently Asked Questions



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  (0.7967)   My niece was diagnosed with Anaplastic Astrocytoma two years ago. At that time, she had 2 brain surgeries and received radiation. Everything was going well until this past September when the tumor reoccured on both sides of the brain and was a GBM. She has undergone Temador and CPT11 and has also had a shunt put in to reduce swelling. Her last MRI showed no sign of the tumor; however, in the past week she has been experiencing shaking of her right arm and some in the left arm as well. No one has been able to explain this since she is not on any medicine that would make this happen. The first major tumor was on the right. Do you have an explanation?
  (0.7967)   My daughter had a Anaplastic Astrocytoma tumor, everything removed and she had radiation. She is still on Dilantin 400 mg a day for over a year now. How long will she have to stay on this level and can this be reduced? Can the operation she had for the tumor cause other problems such as breathing issues. She has some forgetfulness to this day. Wilm this ever go away and what can she do to help improve this? She takes only 2 courses in college because her doctor does not want too much stress on her. How long before that changes?
  (0.7967)   My son-in-law had an Anaplastic Astrocytoma removed 18 months ago from his right posterior frontal lobe. Recently, he started experiencing slurred speech, vomiting and frequent grand mal seizures. Does this signal recurrence? If so, what else can we expect during his last stages?
  (0.7967)   I know that brain tumors have a tendency to run in families. Surprisingly, both my mother and father passed away from brain tumors, my mother about 25 years ago and my father 18 years ago. Six years ago my father's younger brother also passed away after being diagnosed with Anaplastic Astrocytoma. I checked at that time and there were no prior known incidents of anybody else having tumors in the family. I do not have the details on the type of tumors my parents had. All three of them used to live next to a pharmacetical drug company and my father and his brother worked there for a few years. I was born there and we moved to a new place within 2 years. All this haunts me and makes me wonder what to expect. Is there anything I can do to stay on top of this? I know we are still trying to find a cure, forget prevent the occurence of one.
  (0.7967)   Is it recommended for a woman, age 36, with Anaplastic Astrocytoma, who completed radiation and is now doing chemotherapy with Temodar, to have surgery to remove the brain tumor? Is there evidence that surgery prolongs life expectancy?
  (0.7967)   My daughter is 21 and was diagnosed with an Anaplastic Astrocytoma. She had two operations to remove the tumor. She then had 6 weeks of radiation. She has had two MRIs that came back clean. My questions are: 1) when will she be considered a cancer survivor, that is, how many years of clean MRIs does it take, and 2) what is the chance of this tumor returning.
  (0.7742)   What is the difference between diffuse astrocytoma grade three, a GBM, and AA grade three? Is it common for low white counts and low platelet counts to continually delay temodar treatments by a couple of weeks?
  (0.7742)   Hi, I am a 38 year-old male. Right frontal lobe tumor. First surgery on May, 2002, partial debulking. Original size was equivalent to an elongated golf ball. Original diagnosis was a pure Oligodendroglioma, grade II. Second surgery, September 19, 2002, Intra-operative MRI, the bulk of what was resected was Oligo, but with a small portion of tumor with Astrocytes close to the motor strip. My new diagnosis was Anaplastic Astrocytoma, grade III. A very small portion of the tumor was left behind to be treated by radiation and chemo (Temodar). My first MRI last week (1/13/03), post-radiation therapy, was clean, which was expected. I~m in my 3rd of 10 cycles of Temodar. I feel like I~m spinning my wheels researching stuff and I~m starting to see the same info. repeated on several sites. I have two small children and a very strong will to live as long as possible. I~m changing my diet, work out when I can, and doing my due diligence into natural supplements to help my body operate as effectively as possible so it can fight! Is there anything else I can be doing to fight this thing or just have my MRI~s every 3 months and stay in this holding pattern? I know the doctors can only tell me what the ~~stats~~ are regarding prognosis using large populations of patients. I feel like I have a lot going for me, which will enable me to reach the upper limits of the prognosis range given to me. Comments? Thank you.
  (0.7742)   My sister has been fighting Anaplastic Astrocytoma for 3 years. She has had radiation and two surgeries. Recently, something appeared on her MRI, the doctor said it could be scar tissue from the radiation. How long after radiation does scar tissue appear?
  (0.7742)   My husband has Anaplastic Astrocytoma, which was 91% removed. He received radiation and Temodar. His MRI shows no sign of tumor. The doctor said he will keep him on Temodar since it is working. While on Temodar, does this keep the tumor away indefinitely?
  (0.7742)   I was having multiple seizures and was found to have a large (4.3cm x 5cm) Anaplastic Astrocytoma in my right frontal lobe. It was removed a year ago and I have been seizure free until recently. I~ve been on Dilantin so doesn~t the return of seizures mean the return of the tumor? What symtoms should I be aware of for tumor regrowth?
  (0.7742)   Any ideas on how to handle fatigue in a 50 year old male with a Anaplastic Astrocytoma, who is undergoing PCV therapy? He sleeps about 12 hours a day and is tired the time he is up.



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