Anaplastic Astrocytoma
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Trials and Noteworthy Treatments

  Treatment Next 25 Location Last Updated
Details A Pilot Study to Evaluate the Effects of Vaccinations with HLA-A2-Restricted Glioma Antigen-Peptides in Combination with Poly-ICLC for Children with Newly Diagnosed Malignant or Intrinsic Brain Stem Gliomas (BSG) or Incompletely Resected Non-Brainstem High-Grade Gliomas (HGG) or Recurrent Unresectable Low-Grade Gliomas (LGG) or Recurrent High Grade Gliomas Pittsburgh, PA 09/23/2009
Details Vaccination With Lethally Irradiated Glioma Cells Mixed With GM-K562 Cells in Patients Undergoing Craniotomy For Recurrent Tumor Boston, MA 09/06/2009
Details Phase I Dose Escalation Trial of Vandetanib in Combo w Etoposide for Malignant Gliomas Durham, NC 09/05/2009
Details ABTC07-01-Phase I Trial of Aflibercept (VEGF Trap) with Radiation Therapy and Concomitant and Adjuvant Temozolomide in Patients with Malignant Glioma San Francisco, CA 07/07/2009
Details A Phase I Trial and Pharmacokinetic Study of Trabectedin (Yondelis®, ET-743) in Children and Adolescents With Relapsed or Refractory Solid Tumors Bethesda, MD 04/22/2009
Details A Phase I Trial of Enzastaurin (LY317615) in Combination With Carboplatin in Adults With Recurrent Gliomas Bethesda, MD 04/22/2009
Details A Phase I/II Trial of ZD6474 for Patients With Recurrent High-Grade and Progressive Low-Grade Gliomas Bethesda, MD 04/22/2009
Details Multiple Ascending Dose (MAD) Study of the IGF-1R Antagonist R1507 Administered as an Intravenous Infusion in Pediatric Patients With Advanced Solid Tumors. Bethesda, MD 04/22/2009
Details Phase II Trial of Tamoxifen and Bortezomib in Patients With Recurrent High-Grade Gliomas Bethesda, MD 04/22/2009
Details A Phase II Clinical Trial of the Histone Deacetylase Inhibitor Valproic Acid in Combination With Temodar and Radiation Therapy in Patients With High Grade Gliomas Bethesda, MD 04/21/2009
Details A Phase II Trial of Bevacizumab (avastin) and Irinotecan (CPT-11) for Patients With Recurrent High-Grade Gliomas Immediately Following Tumor Progression After Treatment With Bevacizumab Alone: A Companion Trial to NCI Study 06-C-0064 (Bevacizumab Alone for Recurrent Gliomas) Bethesda, MD 04/21/2009
Details A Phase II Trial of Enzastaurin in Combination With Bevacizumab in Adults With Recurrent Malignant Gliomas Bethesda, MD 04/21/2009
Details Phase II Trial of Bevacizumab (Avastin)for Patients With Recurrent High-Grade Glioma Bethesda, MD 04/21/2009
Details A Pharmacokinetic and Phase 2 Study of Sunitinib Malate in Recurrent Malignant Gliomas Toronto, Ontario, CANADA
Bethesda, MD
New York, NY
Cincinnati,, OH
Columbus, OH 		04/21/2009
Details An Open Label Dose Escalation Safety Study of Convection-Enhanced Delivery of IL13-PE38QQR in Patients With Progressive Pediatric Diffuse Infiltrating Brainstem Glioma and Supratentorial High-Grade Glioma Bethesda, MD 04/15/2009
Details Phase I Trial of Conditionally Replication-Competent Adenovirus (Delta-24-RGD4C) for recurrent malignant glioma Houston, TX 04/14/2009
Details A Phase I Trial of Nanoliposomal CPT-11 (NL CPT-11) in Patients With Recurrent High-Grade Gliomas San Francisco, CA 04/06/2009
Details Quality of Life in Patients with Brain Tumors, Skull Base Tumors & Pituitary Adenomas Undergoing Surgical Resection Santa Monica, CA 11/29/2008
Details Bevacizumab (Avastin) and Irinotecan (CPT-11) in Treating Young Patients With Recurrent, Progressive, or Refractory Glioma, Medulloblastoma, Ependymoma, or Low Grade Glioma San Francisco, CA
Washington, DC
Chicago, IL
Boston, MA
Bethesda, MD
Durham, NC
Philadelphia, PA
Pittsburgh, PA
Memphis, TN
Seattle, WA 		11/08/2008
Details A Phase II Trial of Thalidomide in combination with Temozolomide or CPT-11 in patients with recurrent anaplastic gliomas or glioblastoma multiforme Houston, TX 10/27/2008
Details Phase I Trial of Aflibercept (VEGF Trap)with Radiation Therapy and Concomitant and Adjuvant Temozolomide in Patients With Malignant Gliomas Los Angeles, CA
San Francisco, CA
Boston, MA
Durham, NC
New York, NY
Pittsburgh, PA
Houston, TX
San Antonio, TX
Madison, WI 		10/27/2008
Details BIBW 2992 with or without daily temozolomide in the treatment of patients with recurrent malignant glioma Charlottesville, VA 10/20/2008
Details A Phase 1, Open-Label, Dose Escalation Study of ANG1005 in Patients With Malignant Glioma Boston, MA
New York, NY
Houston, TX
Charlottesville, VA 		10/09/2008
Details Erlotinib and Temozolomide With Radiation Therapy in Treating Patients With Glioblastoma Multiforme or Other Brain Tumors Charlottesville, VA 09/30/2008
Details Gliogene: An International Brain Tumor Study Houston, TX 07/24/2008

News Stories

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Frequently Asked Questions



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  (0.7967)   My niece was diagnosed with Anaplastic Astrocytoma two years ago. At that time, she had 2 brain surgeries and received radiation. Everything was going well until this past September when the tumor reoccured on both sides of the brain and was a GBM. She has undergone Temador and CPT11 and has also had a shunt put in to reduce swelling. Her last MRI showed no sign of the tumor; however, in the past week she has been experiencing shaking of her right arm and some in the left arm as well. No one has been able to explain this since she is not on any medicine that would make this happen. The first major tumor was on the right. Do you have an explanation?
  (0.7967)   My daughter had a Anaplastic Astrocytoma tumor, everything removed and she had radiation. She is still on Dilantin 400 mg a day for over a year now. How long will she have to stay on this level and can this be reduced? Can the operation she had for the tumor cause other problems such as breathing issues. She has some forgetfulness to this day. Wilm this ever go away and what can she do to help improve this? She takes only 2 courses in college because her doctor does not want too much stress on her. How long before that changes?
  (0.7967)   My son-in-law had an Anaplastic Astrocytoma removed 18 months ago from his right posterior frontal lobe. Recently, he started experiencing slurred speech, vomiting and frequent grand mal seizures. Does this signal recurrence? If so, what else can we expect during his last stages?
  (0.7967)   I know that brain tumors have a tendency to run in families. Surprisingly, both my mother and father passed away from brain tumors, my mother about 25 years ago and my father 18 years ago. Six years ago my father's younger brother also passed away after being diagnosed with Anaplastic Astrocytoma. I checked at that time and there were no prior known incidents of anybody else having tumors in the family. I do not have the details on the type of tumors my parents had. All three of them used to live next to a pharmacetical drug company and my father and his brother worked there for a few years. I was born there and we moved to a new place within 2 years. All this haunts me and makes me wonder what to expect. Is there anything I can do to stay on top of this? I know we are still trying to find a cure, forget prevent the occurence of one.
  (0.7967)   Is it recommended for a woman, age 36, with Anaplastic Astrocytoma, who completed radiation and is now doing chemotherapy with Temodar, to have surgery to remove the brain tumor? Is there evidence that surgery prolongs life expectancy?
  (0.7967)   My daughter is 21 and was diagnosed with an Anaplastic Astrocytoma. She had two operations to remove the tumor. She then had 6 weeks of radiation. She has had two MRIs that came back clean. My questions are: 1) when will she be considered a cancer survivor, that is, how many years of clean MRIs does it take, and 2) what is the chance of this tumor returning.
  (0.7742)   What is the difference between diffuse astrocytoma grade three, a GBM, and AA grade three? Is it common for low white counts and low platelet counts to continually delay temodar treatments by a couple of weeks?
  (0.7742)   Hi, I am a 38 year-old male. Right frontal lobe tumor. First surgery on May, 2002, partial debulking. Original size was equivalent to an elongated golf ball. Original diagnosis was a pure Oligodendroglioma, grade II. Second surgery, September 19, 2002, Intra-operative MRI, the bulk of what was resected was Oligo, but with a small portion of tumor with Astrocytes close to the motor strip. My new diagnosis was Anaplastic Astrocytoma, grade III. A very small portion of the tumor was left behind to be treated by radiation and chemo (Temodar). My first MRI last week (1/13/03), post-radiation therapy, was clean, which was expected. I~m in my 3rd of 10 cycles of Temodar. I feel like I~m spinning my wheels researching stuff and I~m starting to see the same info. repeated on several sites. I have two small children and a very strong will to live as long as possible. I~m changing my diet, work out when I can, and doing my due diligence into natural supplements to help my body operate as effectively as possible so it can fight! Is there anything else I can be doing to fight this thing or just have my MRI~s every 3 months and stay in this holding pattern? I know the doctors can only tell me what the ~~stats~~ are regarding prognosis using large populations of patients. I feel like I have a lot going for me, which will enable me to reach the upper limits of the prognosis range given to me. Comments? Thank you.
  (0.7742)   My sister has been fighting Anaplastic Astrocytoma for 3 years. She has had radiation and two surgeries. Recently, something appeared on her MRI, the doctor said it could be scar tissue from the radiation. How long after radiation does scar tissue appear?
  (0.7742)   My husband has Anaplastic Astrocytoma, which was 91% removed. He received radiation and Temodar. His MRI shows no sign of tumor. The doctor said he will keep him on Temodar since it is working. While on Temodar, does this keep the tumor away indefinitely?
  (0.7742)   I was having multiple seizures and was found to have a large (4.3cm x 5cm) Anaplastic Astrocytoma in my right frontal lobe. It was removed a year ago and I have been seizure free until recently. I~ve been on Dilantin so doesn~t the return of seizures mean the return of the tumor? What symtoms should I be aware of for tumor regrowth?
  (0.7742)   Any ideas on how to handle fatigue in a 50 year old male with a Anaplastic Astrocytoma, who is undergoing PCV therapy? He sleeps about 12 hours a day and is tired the time he is up.


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